Locus Coeruleus Imaging Markers in Preclinical Alzheimers disease, Cerebrovascular Disease and Cognitive Decline

临床前阿尔茨海默病、脑血管疾病和认知能力下降中的蓝斑成像标志物

基本信息

批准号：
10661433
负责人：
Mark W Bondi
金额：
$ 162.4万
依托单位：
UNIVERSITY OF CALIFORNIA-IRVINE
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-04-01 至 2028-03-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10661433
关键词：
Adrenergic Agents African American Age Alzheimer&apos s Disease American Amyloid Asian Americans Astrocytes Black race Blood Vessels Brain Stem Brain imaging Brain region Cell Nucleus Cells Cerebrovascular Disorders Cerebrum Clinical Cognition Cognitive Collaborations Cross-Sectional Studies Dementia Disease Progression Early Intervention Education Elderly Environment Ethnic Population Genetic Geography Goals Hemorrhage Impaired cognition Institution Intervention Knowledge Late Onset Alzheimer Disease Latinx Lesion Link Longitudinal Studies Magnetic Resonance Imaging Medial Memory Methods Nerve Degeneration Neurons Neuropsychology Non-linear Models Norepinephrine Outcome Participant Pathologic Perfusion Plasma Play Positioning Attribute Predictive Value Protocols documentation Research Personnel Resources Risk Role Sampling Signal Transduction Site Source Stimulus Structure Tauopathies Thick Time Vascular Diseases apolipoprotein E-4 autosomal dominant Alzheimer&apos s disease caucasian American cerebrovascular cognitive function cohort dementia risk demographics ethnic diversity experience follow-up genetic risk factor healthy aging imaging biomarker innovation locus ceruleus structure magnetic resonance imaging biomarker mild cognitive impairment multimodality neuropathology pre-clinical predictive marker racial diversity racial population selective attention sex synucleinopathy tau Proteins tau mutation vascular factor vascular risk factor white matter

项目摘要

Project Summary The proposed study will investigate brain imaging markers of a small brainstem nucleus called the locus coeruleus, which is important for cognitive function and is the first brain region to show Alzheimer’s disease- related changes in older adults who go on develop dementia. The study will examine brain imaging locus coeruleus markers in older adults who go on to have a healthy aging experience over time and in those who go on to develop Alzheimer’s disease, cerebrovascular disease and cognitive decline. By comparing the trajectory of changes in brain imaging markers of the locus coeruleus, we can better understand the potential value of these imaging markers for tracking disease progression from a very early stage.

项目概要拟议的研究将调查称为轨迹的小脑干核的脑成像标记蓝核，对认知功能很重要，也是第一个出现阿尔茨海默病的大脑区域—— 继续发展痴呆症的老年人的相关变化该研究将检查大脑成像轨迹。随着时间的推移，以及那些随着时间的推移而继续拥有健康衰老经历的老年人中的蓝斑标记物通过比较发展轨迹，了解阿尔茨海默病、脑血管疾病和认知能力下降的情况。蓝斑脑成像标志物的变化，我们可以更好地理解其潜在价值这些成像标记物用于从早期阶段追踪疾病进展。