Neuroimaging and Risk Factor Correlates in Aging and MCI

神经影像学和风险因素与衰老和 MCI 相关

• 批准号: 7486760
• 负责人: Mark W Bondi
• 金额: $ 16.54万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-01 至 2012-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7486760
• 关键词: Address; Adult; Age; Aged, 80 and over; Aging; Alzheimer disease detection; Alzheimer' s Disease; Alzheimer' s disease risk; Apolipoprotein E; Appendix; Autopsy; Award; Brain; California; Cerebrum; Clinical; Clinical Investigator; Clinical Research; Cognitive; Consultations; Count; Dementia; Development; Diagnosis; Diffusion Magnetic Resonance Imaging; Disease; Doctor of Philosophy; Early treatment; Elderly; Episodic memory; Functional Magnetic Resonance Imaging; Funding; Genetic Risk; Genotype; Goals; Gray unit of radiation dose; Human; Image; Investigation; Learning; Liquid substance; Longevity; Magnetic Resonance Imaging; Measures; Medial; Memory; Mentors; Mentorship; Methodology; Monitor; Nature; Neocortex; Neurobiology; Neurofibrillary Tangles; Neuropsychological Tests; Neuropsychology; Onset of illness; Participant; Pathogenesis; Pathologic; Performance; Persons; Phase; Process; Psychiatry; Relative (related person); Reporting; Research; Research Activity; Research Personnel; Risk; Risk Factors; Role; Scientist; Senile Plaques; Sleep; Sleep Deprivation; Spin Labels; Staging; Structure; Synapses; TNFRSF5 gene; Techniques; Temporal Lobe; Therapy Clinical Trials; Time; Training; Universities; Variant; aged; blood oxygen level dependent; career; cognitive function; cost; density; executive function; hemodynamics; indexing; interest; memory encoding; memory process; mild neurocognitive impairment; morphometry; neuroimaging; neuropsychological; patient oriented research; pre-clinical; professor; programs; response; skills; white matter; young adult

DESCRIPTION (provided by applicant): This is a re-revised application for a Mid-Career Investigator Award in Patient-Oriented Research (K24). The candidate, Mark W. Bondi, Ph.D., ABPP/CN, Associate Professor of Psychiatry at the University of California San Diego, proposes to pursue a program of research and mentoring activity on the structural and functional neuroimaging changes related to older persons at risk for Alzheimer's disease (AD). The research plan includes two projects for which the candidate is PI, and one as Co-lnvestigator, all of which have been funded and are ongoing, and new research proposed (see Appendix B). The candidate's career goals are (1) to advance his progress in becoming a leader in the scientific study of neuroimaging changes related to those at risk for AD as well as those with preclinical or early clinical AD; (2) to increase his expertise in both established and emerging neuroimaging techniques for translational efforts in clinical detection of AD, its accurate differentiation from other disorders to which older adults are prone, and potential treatment response to therapeutic trials; and (3) to continue to mentor junior scientists and expand such mentorship to the aforementioned skill domains. He has made a strong commitment to integrating neuropsychological and neuroimaging investigations of persons at genetic risk for AD. Activities for his continued career development include (1) consultation with leading research neuroimaging scientists; (2) didactic and experiential training in emerging functional neuroimaging techniques (e.g., arterial spin labeling, diffusion tensor imaging); (3) participation in departmental and campus-wide neuroimaging seminars and meetings; and (4) expanding his capabilities as a research mentor. Funding of this Mid-Career Investigator Award will provide him with the opportunity to substantially increase the time devoted to clinical research activities, thus enhancing his continued development as a clinical investigator and as a mentor to junior clinician investigators interested in the integration of neuropsychology and neuroimaging. Since little is known concerning the underlying functional brain changes in at-risk groups on susceptible cognitive functions prior to AD onset, this application promises to contribute important new methodologies in the characterization of neurobiological substrates surrounding the development of Alzheimer's disease. If successful, our ability to preclinically detect and monitor Alzheimer's disease will have far-reaching implications for early treatment.

描述（由申请人提供）：这是一份重新修订的以患者为导向的研究中职业生涯研究者奖（K24）的申请。候选人 Mark W. Bondi 博士，ABPP/CN，加州大学圣地亚哥分校精神病学副教授，提议开展一项关于与老年人相关的结构和功能神经影像变化的研究和指导活动计划有患阿尔茨海默病 (AD) 的风险。该研究计划包括两个项目，其中候选人是 PI，一个是联合研究员，所有这些项目均已获得资助并正在进行中，并提出了新的研究（见附录 B）。候选人的职业目标是 (1) 推进自己的进步，成为与 AD 风险人群以及临床前或早期临床 AD 患者相关的神经影像学变化科学研究的领导者； (2) 提高他在现有和新兴神经影像技术方面的专业知识，以用于 AD 临床检测的转化工作、AD 与老年人易患的其他疾病的准确区分以及对治疗试验的潜在治疗反应； (3) 继续指导初级科学家并将这种指导范围扩大到上述技能领域。他坚定地致力于整合对 AD 遗传风险人群的神经心理学和神经影像学研究。他持续职业发展的活动包括（1）与领先的神经影像研究科学家进行咨询； (2) 新兴功能性神经影像技术的教学和体验式培训（例如动脉自旋标记、扩散张量成像）； (3) 参加院系和全校范围的神经影像研讨会和会议； (4) 扩大他作为研究导师的能力。该职业生涯中期研究者奖的资助将使他有机会大幅增加投入临床研究活动的时间，从而促进他作为临床研究者的持续发展，并作为对神经心理学和神经影像学整合感兴趣的初级临床医生研究人员的导师。由于人们对 AD 发病前易感认知功能的高危人群的潜在大脑功能变化知之甚少，因此该应用有望为表征阿尔茨海默病发展的神经生物学底物提供重要的新方法。如果成功，我们临床前检测和监测阿尔茨海默病的能力将对早期治疗产生深远的影响。