Multidisciplinary Research Training in Cardiovascular Disease

心血管疾病多学科研究培训

• 批准号: 10656528
• 负责人: Geoffrey S Pitt
• 金额: $ 39.55万
• 依托单位: WEILL MEDICAL COLL OF CORNELL UNIV
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-07-01 至 2027-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10656528
• 关键词: Cardiovascular Diseases; Interdisciplinary Study; Research Training

PROJECT SUMMARY The successful sequencing of the human genome and the evolution of human health services research in the post-genomic era combined with startling advances in imaging technology have offered unprecedented opportunities to transform patient care in cardiovascular diseases. Over the past decade, Weill Cornell Medicine (WCM) has made major investments in biomedical research, as well as research training and infrastructure. WCM requests support for the research training of 4 clinical and non-clinical postdoctoral fellows in a new multidisciplinary research training program (MRTP) in Cardiovascular Disease, with WCM providing funding for an additional training slot. The objective is to recruit outstanding candidates with solid foundations in basic science and/or clinical research and train them to apply their knowledge and skills towards addressing important clinically unmet needs in the prevention, diagnosis, and treatment of patients with cardiovascular diseases. MRTP trainees will receive program support for 3 years during which they will follow a structured and rigorous postdoctoral training program. The MRTP will be a joint effort of 20 eminent preceptors from WCM, Memorial Sloan Kettering Cancer Center (MSKCC) and the Rockefeller University (RU), which constitute a dense network of collaborative researchers, who are international leaders in fields directly relevant to cardiovascular physiology and disease. These preceptors have been organized into 2 themed, but interconnected units of research training: molecular and cell signaling and cardiovascular imaging. These training units will enable the development of content-specific educational programming, as well as increase the efficiency administration within the training program. Oversight will be provided by a Research Training Executive Committee consisting of the Program Director and two Associate Program Directors, who will also serve as leaders of the training units, as well as 3 additional members who will provide specific guidance on clinical/epidemiologic research, on achieving and maintaining diversity within the training program, and on mentoring. We have also assembled an outstanding roster of internal and external advisory board members with a mandate to evaluate the program and provide specific recommendations to improve both its quality and efficiency. The MRTP's highly personalized training program will include 1) individual development plans; 2) rigorous research training; 3) hands-on experience in cutting-edge methodologies; and 4) an integrated curriculum. Trainees will further benefit from the extensive institutional resources of WCM, MSKCC and RU. Based upon the levels of interest in our fellowship programs, we anticipate a substantial pool of highly qualified clinical and non-clinical candidates for the proposed MRTP, which will maintain a strong diversity focus. Through its rigorous, structured and highly personalized curriculum, this new training program seeks to train future leaders in cardiovascular disease research who are prepared to translate their findings towards improving patient care.

项目概要 人类基因组测序的成功和人类健康服务研究的进展 后基因组时代与成像技术的惊人进步相结合，提供了前所未有的 改变心血管疾病患者护理的机会。过去十年，威尔康奈尔医学 （WCM）在生物医学研究以及研究培训和基础设施方面进行了大量投资。 WCM 请求支持 4 名临床和非临床博士后研究员的研究培训 心血管疾病多学科研究培训计划 (MRTP)，由 WCM 提供资金 额外的培训槽位。目的是招募具有扎实基础知识的优秀候选人 科学和/或临床研究，并培训他们运用知识和技能来解决重要问题 心血管疾病患者的预防、诊断和治疗方面的临床需求未得到满足。 MRTP 学员将获得为期 3 年的计划支持，在此期间他们将遵循结构化且严格的计划 博士后培养计划。 MRTP 将由来自 WCM、Memorial 的 20 名杰出导师共同努力 斯隆凯特琳癌症中心 (MSKCC) 和洛克菲勒大学 (RU)，构成密集的网络 合作研究人员，他们是与心血管生理学直接相关领域的国际领导者 和疾病。这些导师被分为 2 个主题但相互关联的研究培训单元： 分子和细胞信号传导以及心血管成像。这些培训单位将有助于发展 针对具体内容的教育规划，以及提高培训管理效率 程序。由该计划组成的研究培训执行委员会将提供监督 主任和两名项目副主任，他们还将担任培训单位的领导，以及 3 名 其他成员将为临床/流行病学研究、实现和 保持培训计划和指导的多样性。我们还集结了优秀的 内部和外部顾问委员会成员名册，其任务是评估该计划并提供 提高其质量和效率的具体建议。 MRTP 的高度个性化培训 计划将包括 1) 个人发展计划； 2）严格的科研训练； 3）实际操作经验 尖端方法论； 4）综合课程。学员将进一步受益于广泛的 WCM、MSKCC 和 RU 的机构资源。根据对我们的奖学金计划的兴趣程度， 我们预计拟议的 MRTP 将有大量高素质的临床和非临床候选人， 这将保持强烈的多元化关注。通过其严谨、结构化和高度个性化的课程， 这项新的培训计划旨在培训心血管疾病研究领域的未来领导者，他们准备好 将他们的发现转化为改善患者护理。

项目成果

Mortality after sternal reconstruction with pectoralis major flap vs omental flap for postsurgical mediastinitis: A systematic review and meta-analysis.

胸大肌瓣与大网膜瓣重建胸骨后纵隔炎的死亡率：系统评价和荟萃分析。

• 发表时间: 2022-12
• 影响因子: 1.6
• 作者: Cancelli, Gianmarco;Alzghari, Talal;Dimagli, Arnaldo;Audisio, Katia;Dabsha, Anas;Harik, Lamia;Olaria, Roberto Perezgrovas;Soletti, Giovanni J;Demetres, Michelle;Gaudino, Mario
• 通讯作者: Gaudino, Mario

The Effect of Posterior Pericardiotomy on the Incidence of Atrial Fibrillation After Cardiac Surgery-Extended Follow-Up study (PALACS-EF): rationale and design.

后路心包切开术对心脏手术后心房颤动发生率的影响 - 延长随访研究 (PAALACS-EF)：基本原理和设计。

• 发表时间: 2023-11
• 作者: Gaudino, Mario;Harik, Lamia;Redfors, Bjorn;Sandner, Sigrid;Alexander, John H;Di Franco, Antonino;Dimagli, Arnaldo;Weinsaft, Jonathon;Perezgrovas;Soletti, Giovanni Jr;Lau, Christopher;Mack, Charles;Girardi, Leonard
• 通讯作者: Girardi, Leonard

Sex differences in saphenous vein graft patency: A systematic review and meta-analysis.

大隐静脉移植物通畅的性别差异：系统评价和荟萃分析。

• 发表时间: 2022-12
• 影响因子: 1.6
• 作者: Lehtinen, Miia L;Harik, Lamia;Soletti, Giovanni;Rahouma, Mohamed;Dimagli, Arnaldo;Perezgrovas;Audisio, Katia;Demetres, Michelle;Gaudino, Mario
• 通讯作者: Gaudino, Mario

Commentary: No difference in postoperative surveillance between bicuspid aortic valve and tricuspid aortic valve patients after aortic surgery? Not so fast.

评论：主动脉手术后二尖瓣和三尖瓣患者的术后监测没有差异吗？

• 发表时间: 2023-01-07
• 作者: Harik, Lamia;Gaudino, Mario
• 通讯作者: Gaudino, Mario

Spinal cord injury after open and endovascular repair of descending thoracic aneurysm and thoracoabdominal aortic aneurysm: an updated systematic review and meta-analysis.

胸降动脉瘤和胸腹主动脉瘤开放和血管内修复术后脊髓损伤：更新的系统评价和荟萃分析。

• 发表时间: 2023-09-28
• 作者: Alzghari, Talal;An, Kevin R;Harik, Lamia;Rahouma, Mohamed;Dimagli, Arnaldo;Perezgorvas;Demetres, Michelle;Cancelli, Gianmarco;Soletti Jr, Giovanni;Lau, Christopher;Girardi, Leonard N;Gaudino, Mario
• 通讯作者: Gaudino, Mario