Portable photoacoustic microscopy

便携式光声显微镜

基本信息

批准号：
7656172
负责人：
Jian Liu
金额：
$ 10.01万
依托单位：
POLARONYX, INC.
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-05-01 至 2009-12-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7656172
关键词：
Amplifiers Animal Experimentation Animals Award Ballistics Biological Biotechnology Blood Vessels Brain Cellular biology Clinic Collaborations Confocal Microscopy Contrast Media Development Diagnostic Fiber Functional Imaging Generations Hemoglobin Image Imaging technology Industry Investigation Lasers Malignant neoplasm of brain Malignant neoplasm of cervix uteri Methyl Green Microscopy Molecular Molecular Probes Morphologic artifacts Nature Noise Optical Coherence Tomography Optics Output Oxygen Phase Physiologic pulse Physiological Play Production Publishing Pump Records Research Residual state Resolution Role Shapes Skin Cancer Small Business Innovation Research Grant Speed System Techniques Technology Testing Time Tissues Ultrasonics Ultrasonography Universities Washington Width Work absorption angiogenesis base clinical Diagnosis clinical application clinical practice commercialization cost design drug discovery imaging modality in vivo innovation lysophosphatidic acid malignant breast neoplasm medical specialties molecular imaging nanosecond novel optical imaging prototype public health relevance second harmonic two-photon

项目摘要

DESCRIPTION (provided by applicant): This SBIR phase I project proposes a novel all-fiber and ultra compact high power nanosecond fiber laser system by using our proprietary technologies on spectral shaping and pulse shaping. The proposed idea is an enabling technology for portable photoacoustic microscopy. It is a specialty fiber based MOPA. Our unique spectral shaping techniques enable us to reduce the SBS and ASE noise significantly in the amplifier for commercially available YDFs and to reuse the residual pump to further increase the efficiency. These will make the fiber laser system superior in terms of wall plug efficiency (over 20%), power (>10 W and > 100 kW peak power), noise, size, and cost. The cost and size will be at least ten times cheaper than other competing approaches. The design is simpler in construction and easy to operate. In Phase I time frame, a prototype 1064 nm fiber laser operating at output energy of 0.5 mJ will be built up and preliminary test will be done for imaging. Fine tuning of the product to achieve more compact size and generation of second harmonic green light laser and several imaging applications (in collaboration with Washington University) will be given in Phase II with an investigation of volume production. PUBLIC HEALTH RELEVANCE: The proposed portable photoacoustic microscopy provides a breakthrough in applying nanosecond fiber laser technology into real clinic. Though photoacoustic microscopy is our first application in obtaining deep tissue high resolution image, it will have significant impact to other biomedical applications.

描述（由申请人提供）：该SBIR I期项目提出了一种新型的全纤维和超紧凑的高功率纳米纤维激光器系统，通过使用我们的专有技术来进行光谱形状和脉冲形状。拟议的想法是一种用于便携式光声显微镜的促成技术。这是一种基于特种纤维的MOPA。我们独特的光谱塑形技术使我们能够在放大器中显着降低SBS和ASE噪声，以获得市售的YDF，并重用残留泵以进一步提高效率。这些将使纤维激光系统在墙壁塞效率（超过20％），功率（> 10 W和> 100 kW峰值功率），噪声，尺寸和成本方面提高。成本和规模至少比其他竞争方法便宜十倍。该设计的构造更简单，易于操作。在第一阶段的时间范围内，将建立以0.5 MJ运行的原型1064 nm光纤激光器，并将进行初步测试以进行成像。对产品进行微调，以实现更紧凑的尺寸和第二次谐波绿光激光器和几种成像应用（与华盛顿大学合作），并将在II阶段进行研究。公共卫生相关性：拟议的便携式光声显微镜为将纳秒纤维激光技术应用于真实诊所提供了突破。尽管光声显微镜是我们在获得深组织高分辨率图像时的首次应用，但它将对其他生物医学应用产生重大影响。