Implantable Microphones for Fully Implantable Hearing Prosthetics

用于完全植入式听力修复术的植入式麦克风

• 批准号: 10376031
• 负责人: Jeffrey H Lang
• 金额: $ 32.68万
• 依托单位: MASSACHUSETTS EYE AND EAR INFIRMARY
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-04-01 至 2024-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10376031
• 关键词: Acoustic Stimulation; Acoustics; Adoption; Age; Amplifiers; Anatomy; Animal Experimentation; Animal Testing; Animals; Auditory Prosthesis; Bionics; Brain; Cadaver; Child; Cicatrix; Clinical Trials; Cochlea; Cochlear Implants; Cone; Cosmetics; Coupling; Cues; Detection; Development; Devices; Dimensions; Distal; Ear; Elderly; Electronics; Encapsulated; Environment; Evaluation; External Ear; External auditory canal; Film; Frequencies; Geometry; Goals; Grant; Head; Hearing; Hearing Aids; Human; Implant; Implanted Electrodes; Labyrinth; Length; Life Style; Liquid substance; Location; Malleus; Measurement; Mechanics; Membrane; Metals; Middle Ear Implant; Modeling; Motion; Noise; Patients; Performance; Physical activity; Polymers; Positioning Attribute; Preparation; Promontory; Property; Readiness; Risk; Shapes; Signal Transduction; Silicone Elastomers; Sleep; Specimen; Sports; System; Testing; Thinness; Time; Trauma; Tympanic membrane; Work; base; design; dexterity; implantation; improved; microphone; middle ear; polyvinylidene fluoride; pressure; pressure sensor; prevent; programs; prototype; research clinical testing; response; sensor; sound; vibration

Project Summary We are developing implantable microphones for assistive hearing devices, which are essential for enabling prosthetic hearing devices such as cochlear implants (CI) and middle-ear implants to become fully implantable. Fully-implanted systems offer significant advantages over conventional devices with external microphones: access to hearing 24/7 (such as when sleeping), which can benefit children's brain development and prevent limitations on activities and lifestyles for all ages; benefit from the external ear's acoustic enhancement to improve hearing in noisy environments; ease of use (less challenges in dexterity); cosmetic appeal. We have successfully developed proof-of-concept prototypes for each microphone design and have demonstrated ease of implantation and high-fidelity responses in fresh human cadaveric ears. In this application we focus on two basic microphone designs, with the goal that at the end of the project they will be ready for large-animal experimentation and/or clinical trials. One is an intracochlear microphone embedded within a cochlear implant that senses inner-ear pressure. The other is a motion-sensing device that attaches to the distal end of the malleus, the umbo, within the middle-ear cavity. The devices are based on polyvinylidene fluoride (PVDF), a piezoelectric polymer. The fabrication of the devices starts with a PVDF film, which is metalized to form electrical contacts to transmit the piezoelectric signal. They are then encapsulated and electrically shielded. The devices, already operating at a useful level, will be modeled, evaluated and refined to perform at a level comparable to hearing aid microphones, with high sensitivity, low noise and flat response over a wide bandwidth.

项目摘要 我们正在开发可植入的麦克风，用于辅助听力设备，这对于 启用假肢听力设备，例如人工耳蜗（CI）和中耳植入物 完全植入。与传统设备相比，完全插入的系统具有 外部麦克风：访问24/7的听力（例如睡觉时），这可以使儿童大脑受益 开发并防止对所有年龄段的活动和生活方式的局限性；受益于外耳的 在嘈杂环境中改善听力的声学增强；易用性（更少的挑战 灵巧）;美容吸引力。我们已经成功地为每个人开发了概念验证原型 麦克风设计，并表现出易于植入和高保真反应 人尸体耳朵。在此应用中，我们专注于两个基本麦克风设计，目标是 该项目的终结将准备进行大动物实验和/或临床试验。一个是一个 嵌入感受内耳压的人工耳蜗内的麦克风内麦克风。另一个是 连接到中耳内乳腺末端的运动传感器 腔。这些设备基于聚乙烯氟（PVDF），一种压电聚合物。这 设备的制造始于PVDF膜，该膜被金属化以形成电气接触 传输压电信号。然后将它们封装并进行电屏蔽。设备， 已经以有用的水平运行，将被建模，评估和完善以在一个级别上执行 与助听器麦克风相媲美，具有高灵敏度，低噪声和平坦的响应 带宽。