Methods for Fast and Efficient Oxygen Imaging

快速高效的氧气成像方法

• 批准号: 10698818
• 负责人: Mrignayani Kotecha
• 金额: $ 40万
• 依托单位: O2M TECHNOLOGIES, LLC
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-06 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10698818
• 关键词: 3-Dimensional; Acceleration; Acute; Animal Model; Attention; Clinic; Clinical; Complex; Computer software; Development; Electron Spin Resonance Spectroscopy; Environment; Evaluation; Fast Electron; Frequencies; Future; Goals; Hour; Human; Hypoxia; Image; Imaging Device; Inbred C3H Mice; Individual; Injury; Leg; Letters; Licensing; Machine Learning; Malignant Neoplasms; Maps; Measurement; Measures; Methods; Modeling; Myocardial Infarction; National Cancer Institute; Organ Transplantation; Oxygen; Pathway interactions; Performance; Perfusion; Periodicity; Phase; Physiologic pulse; Process; Radiation Dose Unit; Radiation therapy; Reporting; Resolution; Scientist; Speed; Stroke; System; Techniques; Technology; Testing; Time; Tissues; Tumor Biology; United States National Institutes of Health; Width; absorption; cancer imaging; cancer therapy; computerized data processing; deep learning; design; drug development; fibrosarcoma; image reconstruction; imager; imaging modality; imaging software; improved; in vivo; in vivo imaging; instrument; learning network; mouse model; pre-clinical; pressure; reconstruction; response; success; technology platform; therapy resistant; tool; tumor; tumor hypoxia

Abstract Intermittent or acute/cyclic hypoxia in tumors, with frequencies between a few cycles per minute to hours, is receiving increased attention because this type of hypoxia has been reported to have an influence on tumor malignancy as well as treatment resistance via increased expression of pro-survival pathways. Fast oxygen imaging methods are needed for the measurement of acute tumor hypoxia. Pulse electron paramagnetic resonance imaging (pEPRI) is a promising tool to provide three-dimensional partial oxygen pressure (pO2) maps in live tissues and tumors to assist with advanced studies of tumor biology, perfusion, drug development, and radiation treatment. Single point imaging (SPI), an acquisition technique developed at National Cancer Institute (NCI), is a subset of pEPRI methods that can be used for oxygen image acquisition. It provides high-resolution, high-fidelity images but is slow due to the need for acquiring each k-space point individually. In the current project, our goal is to improve the image acquisition speed of SPI by utilizing a combination of advanced hardware and deep learning. This will improve the imaging speed by many folds without compromising the image quality. These advances will be tested in a mouse model of fibrosarcoma tumor. This project will bring an NIH-developed technology to the commercial level. Our long-term goal is to imply the advanced hardware and software technologies of oxygen imaging to clinics to assist with oxygen-guided tumor treatments.

抽象的 肿瘤中间歇性或急性/周期性缺氧，其频率在每分钟几个周期到几小时之间， 受到越来越多的关注，因为据报道这种类型的缺氧对肿瘤有影响 通过增加促生存途径的表达来抑制恶性肿瘤以及治疗耐药。快速吸氧 需要成像方法来测量急性肿瘤缺氧。脉冲电子顺磁 共振成像 (pEPRI) 是一种很有前途的工具，可提供三维氧分压 (pO2) 图 在活组织和肿瘤中协助肿瘤生物学、灌注、药物开发和的高级研究 放射治疗。单点成像 (SPI)，美国国家癌症研究所开发的一种采集技术 (NCI) 是 pEPRI 方法的子集，可用于氧气图像采集。它提供高分辨率、 高保真图像，但由于需要单独获取每个 k 空间点，速度很慢。在当前 项目中，我们的目标是通过结合先进的技术来提高 SPI 的图像采集速度 硬件和深度学习。这将在不影响成像速度的情况下将成像速度提高许多倍 图像质量。这些进展将在纤维肉瘤小鼠模型中进行测试。该项目将带来 NIH 开发的技术已达到商业水平。我们的长期目标是暗示先进的硬件和 向诊所提供氧气成像软件技术，以协助氧气引导肿瘤治疗。