Off-the-shelf Dental Regeneration Technologies

现成的牙齿再生技术

• 批准号: 8677574
• 负责人: Jeremy Mao
• 金额: $ 66.5万
• 依托单位: INNOVATIVE ELEMENTS, LLC
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-09 至 2016-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8677574
• 关键词: Academic Medical Centers; Acute; Affect; Age; Alkaline Phosphatase; American; Amputation; Animal Model; Animals; Apical; BMP2 gene; Businesses; Cells; Centers for Disease Control and Prevention (U.S.); Common Cold; Composite Resins; Cues; Data; Dental; Dental Care; Dental Cementum; Dental Enamel; Dental Instruments; Dental Pulp; Dental caries; Dentin; Dentin Formation; Dentists; Dose; Drug Formulations; Elements; Endodontics; Enzyme-Linked Immunosorbent Assay; Excision; Face; Filler; Flow Cytometry; Foundations; Funding; Goals; Grant; Incubators; Infection; Kinetics; Laboratories; Lead; Life; Measures; Natural regeneration; Odontoblasts; Odontogenesis; Outcome Measure; Pain; Patients; Phase; Plant Roots; Private Sector; Process; Pulp Canals; Randomized Clinical Trials; Randomized Controlled Clinical Trials; Research Infrastructure; Services; Shipping; Ships; Side; Small Business Innovation Research Grant; Source; Staging; Stem cells; Structure; Systemic infection; Technology; Testing; Time; Tissues; Tooth Crowns; Tooth Fractures; Tooth Loss; Tooth structure; Toothache; Trauma; United States; Universities; Visit; Work; alveolar bone; commercialization; controlled release; cytokine; deciduous tooth; design; experience; human disease; immunocytochemistry; in vivo; innovation; mineralization; pathogen; periapical; permanent tooth; pre-clinical; preclinical study; product development; public health relevance; research study; scaffold; secondary infection; stem

DESCRIPTION (provided by applicant): Dentin forms the bulk of the tooth and is covered by enamel in the crown of the tooth and cementum in the root. When dental caries breaks down enamel and involves the dentin, the patient experiences pain and thermal sensitivity. The acute phase of dental pulp infection is typically associated with excruciating pain, and if not properly managed, can lead to peri-apical infection, tooth loss, facial infection and even systemic infections such as endocardiomyotis. Current dental treatments for tooth decay rely on surgical removal of decayed enamel and dentin by dental instruments and filling of the prepared cavity with artificial materials including amalgam and composite resin. However, current restorative dental treatments by artificial fillers have finite service life and can fail unpredictably. Tooth fracture and secondary infections are among some of the well documented complications of current dental and endodontic treatments. Treatment options are further limited for deciduous teeth and young permanent teeth. We have discovered that dentin-like tissues can regenerate by bioactive scaffold formulations in our SBIR Phase I related work. The overall goal of this SBIR/Phase-2 proposal is to identify and prepare efficacious and safe bioactive scaffold formulations for the regeneration of dentin-like tissues. This SBIR-Phase 2 represents essential intermediate funding to advance our technologies to the next stage of commercialization and eventually into a product that can ultimately regenerate dentin in patients who suffer from dental pain, trauma and infections.

描述（由申请人提供）：牙本质形成大部分牙齿，并在根部牙齿的牙冠和牙骨质中被牙釉质覆盖。当龋齿分解搪瓷并涉及牙本质时，患者会疼痛和热敏感性。牙髓感染的急性相通常与疼痛的疼痛相关，如果无法正确控制，可能会导致痛苦的感染，牙齿脱落，面部感染，甚至是心内膜心脏瘤等全身感染。当前的牙齿腐烂牙科处理取决于通过牙科仪器的手术去除腐烂的搪瓷和牙本质，并用包括汞合金和复合树脂在内的人工材料填充准备的腔。但是，人造填充剂的当前恢复性牙齿治疗寿命有限，并且可能无法预测。牙齿骨折和继发感染是当前牙齿和牙髓治疗的某些并发症之一。治疗选择进一步限制了落叶牙齿和年轻的恒牙。我们发现，在SBIR I期相关的工作中，牙本质样组织可以通过生物活性支架制剂再生。该SBIR/阶段2提案的总体目标是识别和准备有效且安全的生物活性支架配方，以使牙本质样组织的再生。该SBIR期2代表了必不可少的中间资金，可以将我们的技术推向下一阶段的商业化阶段，并最终成为一种最终可以在患有牙齿疼痛，创伤和感染的患者中再生牙本质的产品。