CVD and Metabolic Complications of HIV/AIDS Data Coordinating Center

HIV/AIDS数据协调中心的CVD和代谢并发症

• 批准号: 7881416
• 负责人: Elizabeth Renata Brown
• 金额: $ 98.53万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-25 至 2013-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7881416
• 关键词: AIDS/HIV problem; Address; Area; Biological Markers; Calcium; Cardiac; Cardiovascular Diseases; Cardiovascular system; Clinic Visits; Communication; Coronary; Coronary Arteriosclerosis; Data; Data Analyses; Data Collection; Data Coordinating Center; Databases; Development; Directories; Disease; Documentation; Ensure; Evaluation; Exposure to; Fostering; Funding Opportunities; Goals; HIV; HIV Infections; Health; Highly Active Antiretroviral Therapy; Incidence; Individual; Life; Life Expectancy; Manuscripts; Medical; Metabolic; Methodology; National Heart, Lung, and Blood Institute; Nature; Patients; Play; Preparation; Protocols documentation; Publications; Published Directory; Randomized; Readiness; Reading; Reporting; Research; Research Activity; Research Design; Research Personnel; Resources; Role; Running; Sample Size; Schedule; Scheme; Site; Specimen; Standardization; Universities; Washington; Writing; abstracting; cardiovascular disorder risk; cardiovascular risk factor; clinical research site; data integration; design; disorder risk; experience; imaging modality; meetings; novel; prevent; programs; protocol development; repository; response; symposium; tool; treatment strategy; web site

DESCRIPTION (provided by applicant): This proposal is written in response to an NHLBI FOA requesting a Data Coordinating Center (DCC) for RFA-HL-08-003 Mechanisms and Management of Cardiovascular and Metabolic Complications of HIV/AIDS. The purpose of the FOA is to foster collaborative research to elucidate the underlying mechanisms of metabolic and anthropometric abnormalities seen in HIV infection and highly active antiretroviral therapy and their relationship to cardiovascular disease risk. In this application, we propose to run the DCC from the Collaborative Health Studies Coordinating Center (CHSCC) at the University of Washington. The DCC will be responsible for coordinating studies at 6-7 clinical sites engaged in separate, but complimentary research agendas. Although the studies will all involve research that addresses the title of this RFA, the size and scope of these studies has yet to be fully determined. The DCC will play a key role in coordination and management of these studies. Its key responsibilities will include facilitation of data harmonization, standardization of study protocols where appropriate, facilitating data and specimen banking, scheduling and facilitating investigator meetings, coordinating centralized readings of cardiac evaluations and providing statistical expertise and support in protocol development, data analysis and preparation of presentations and manuscripts. This application describes our relevant experience and preparedness in these areas as well as others crucial to efficiently running a DCC. It also presents our plans for running the DCC for this group of studies. HIV-infected individuals have increased life expectancies since the introduction of highly active antiretroviral therapy (HAART). With this increased life expectancy come increased incidences of metabolic complications and cardiovascular disease (CVD) associated with living with HIV/AIDS and prolonged exposure to HAART. Studying how these diseases interact with HIV and HAART can help prevent their development and progression in HIV-infected individuals. (End of Abstract)

描述（由申请人提供）： 该提案是针对NHLBI FOA的响应，该NHLBI FOA要求对RFA-HL-08-003机制进行数据协调中心（DCC）以及HIV/AIDS的心血管和代谢并发症的管理。 FOA的目的是促进协作研究，以阐明HIV感染和高度活跃的抗逆转录病毒疗法的代谢和人体测量异常的潜在机制及其与心血管疾病风险的关系。在此应用程序中，我们建议从华盛顿大学的合作健康研究中心（CHSCC）运行DCC。 DCC将负责在参与单独但免费研究议程的6-7个临床部位进行协调研究。尽管这些研究都将涉及解决此RFA标题的研究，但这些研究的规模和范围尚未得到充分确定。 DCC将在这些研究的协调和管理中发挥关键作用。它的关键职责将包括促进数据协调，在适当的情况下进行研究方案的标准化，促进数据和标本银行业务，调度和促进调查人员会议，协调心脏评估的集中式读取以及在协议开发，数据分析以及演讲和手册的协议开发，数据分析和准备方面提供统计专业知识和支持。该应用程序描述了我们在这些领域的相关经验和准备，以及其他对有效运行DCC至关重要的问题。它还提出了我们为这组研究运行DCC的计划。自引入高度活跃的抗逆转录病毒疗法（HAART）以来，艾滋病毒感染者的寿命增加。随着预期寿命的增加，与艾滋病毒/艾滋病生活以及长期暴露于HAART有关的代谢并发症和心血管疾病（CVD）的发生率增加。研究这些疾病如何与HIV和HAART相互作用可以帮助防止其艾滋病毒感染者的发展和进展。 （抽象的结尾）