2009 Stress Proteins in Growth, Development, and Disease Gordon Research Conferen

2009 年生长、发育和疾病中的应激蛋白戈登研究会议

• 批准号: 7663377
• 负责人: JEFFREY L. BRODSKY
• 金额: $ 1.59万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-03-15 至 2010-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7663377
• 关键词: Academy; Affect; African American; Age; Aging; Alzheimer' s Disease; Biological Models; Cell Aging; Cells; Cellular Stress Response; Collaborations; Commit; Defect; Disabled Persons; Disease; Ensure; Exhibits; Finland; Genes; Growth and Development function; Health; Heat shock proteins; Human; Huntington Disease; Infection; Lead; Life; Link; Malignant Neoplasms; Metabolic Diseases; Neurons; Nutrient; Organism; Parkinson Disease; Pathway interactions; Proteins; Recording of previous events; Regulation; Research; Research Personnel; Role; Schedule; Scientist; Series; Stress; Time; Universities; Woman; abstracting; biological adaptation to stress; cell age; handicapping condition; human disease; meetings; posters; preference; prevent; protein function; public health relevance; rapid growth; stress protein; symposium

DESCRIPTION (provided by applicant): The ability of organisms to withstand stress is critical for survival, and there is a growing appreciation that cellular stress responses are vital during growth and development. In fact, an increasing number of human diseases-particularly those affecting neurons-arise from defects in stress response pathways or from the inability of stress proteins to protect cells. Stress response pathways have also been linked to ageing, infection, cancer, and metabolic diseases. Not surprisingly, then, significant efforts to modulate the stress response have been taken by biomedical researchers. Therefore, it is critical that a forum is provided to assemble scientists who seek to connect the mechanisms underlying human diseases with the regulation of stress genes and with stress protein function. One of the premier forums for this unique assembly is the "Stress Proteins in Growth, Development and Disease" Gordon Research Conference (GRC). The next conference, which is the fifth in this series, will be held from June 28th - July 3rd, 2009, at the Proctor Academy in Andover, NH. The Chair for this meeting is Jeffrey Brodsky (University of Pittsburgh, Pittsburgh, PA) and the Vice-Chair is Lea Sistonen (Abo Akademi University, Turku, Finland). The Proctor Academy has a long history in supporting GRCs and is handicapped accessible. Thus far, 26 internationally recognized speakers have committed to attending and speaking at the 2009 meeting, including 10 women and one African-American. Nevertheless, significant efforts will be undertaken to increase the diversity of meeting attendees, to bring more scientists into the stress protein field, and to catalyze the formation of new collaborations. To this end, the schedule has been prepared so that 10 speaking slots will be chosen from abstracts submitted for poster presentations, and preference will be given to younger scientists and to those from under-represented groups. The meeting schedule will also be prepared to ensure that different model systems are equally represented. In addition, meeting attendance will be "capped" at 150 to facilitate effective interactions and discussions. Overall, we seek to enhance the dissemination of cutting-edge advances and the formation of new collaborations in the stress protein field. This, in turn, will lead to advances and broaden our understanding of the roles of stress proteins in human health, aging, and disease. Cells-especially neurons-live under harsh conditions. There are times when cells are starved for nutrients, times when cells need to exhibit rapid growth, and times when cells are exposed to toxic agents. Cells may also express misshapen proteins, as occurs in Alzheimer's, Huntington's, and Parkinson's disease. However, to off-set the dangerous consequences of stress, which can lead not only to disease but also to ageing, cells produce specific proteins to protect themselves. The 2009 Gordon Research Conference, entitled "Stress Proteins in Growth, Development, and Disease", brings together scientists who study the link between stress and human disease, and provides a unique forum for researchers in this field to assemble and identify new avenues to prevent stress-related diseases. PUBLIC HEALTH RELEVANCE: Cells-especially neurons-live under harsh conditions. There are times when cells are starved for nutrients, times when cells need to exhibit rapid growth, and times when cells are exposed to toxic agents. Cells may also express misshapen proteins, as occurs in Alzheimer's, Huntington's, and Parkinson's disease. However, to off-set the dangerous consequences of stress, which can lead not only to disease but also to ageing, cells produce specific proteins to protect themselves. The 2009 Gordon Research Conference, entitled "Stress Proteins in Growth, Development, and Disease", brings together scientists who study the link between stress and human disease, and provides a unique forum for researchers in this field to assemble and identify new avenues to prevent stress-related diseases.

描述（由申请人提供）：有机体承受压力的能力对于生存至关重要，并且越来越多地认为细胞应力反应在生长和发育中至关重要。实际上，越来越多的人类疾病尤其是那些影响神经元的人 - 因应激反应途径中的缺陷或无法应激蛋白保护细胞的缺陷而影响。压力反应途径也与衰老，感染，癌症和代谢疾病有关。因此，毫不奇怪，生物医学研究人员已经采取了重大努力来调节压力反应。因此，至关重要的是，要提供一个论坛来组装试图将人类疾病潜在机制与压力基因的调节和应激蛋白功能联系起来的科学家。这个独特组装的主要论坛之一是“增长，发展和疾病中的压力蛋白”戈登研究会议（GRC）。下一个会议是本系列的第五次会议，将于2009年6月28日至7月3日在新罕布什尔州安多佛市的Proctor Academy举行。这次会议的主席是杰弗里·布罗德斯基（Jeffrey Brodsky）（宾夕法尼亚州匹兹堡大学匹兹堡大学），副主席是Lea Sistonen（芬兰图尔库的Abo Akademi University）。 Proctor Academy在支持GRC方面有很长的历史，并且可以访问残障。到目前为止，有26位国际认可的发言人承诺在2009年的会议上参加和讲话，其中包括10名妇女和一名非裔美国人。然而，将采取重大努力来增加与会者的多样性，将更多的科学家带入压力蛋白领域，并促进新合作的形成。为此，准备时间表已经准备好，以便从提交海报演示的摘要中选择10个口语插槽，并将优先考虑年轻的科学家和代表性不足的群体的偏好。会议时间表还将准备好确保同样代表不同的模型系统。此外，会议的出席率将在150处“限制”，以促进有效的互动和讨论。总体而言，我们试图增强尖端进步的传播以及应力蛋白领域中新的合作的形成。反过来，这将导致进步并扩大我们对应激蛋白在人类健康，衰老和疾病中的作用的理解。细胞 - 尤其是在恶劣条件下神经元活的。有时，细胞因营养而饥饿，细胞需要快速生长以及细胞暴露于有毒剂的时间。细胞还可以表达畸形的蛋白质，如阿尔茨海默氏症，亨廷顿和帕金森氏病。但是，为了避开压力的危险后果，这不仅会导致疾病，而且会导致衰老，细胞会产生特定的蛋白质来保护自己。 2009年的戈登研究会议题为“生长，发育和疾病中的压力蛋白”，汇集了研究压力与人类疾病之间联系的科学家，并为该领域的研究人员提供了一个独特的论坛，以组装和识别与压力相关疾病的新途径。 公共卫生相关性：细胞，尤其是在恶劣条件下神经元活着的。有时，细胞因营养而饥饿，细胞需要快速生长以及细胞暴露于有毒剂的时间。细胞还可以表达畸形的蛋白质，如阿尔茨海默氏症，亨廷顿和帕金森氏病。但是，为了避开压力的危险后果，这不仅会导致疾病，而且会导致衰老，细胞会产生特定的蛋白质来保护自己。 2009年的戈登研究会议题为“生长，发育和疾病中的压力蛋白”，汇集了研究压力与人类疾病之间联系的科学家，并为该领域的研究人员提供了一个独特的论坛，以组装和识别与压力相关疾病的新途径。