Reconfigurable MRI technology for safe and high-resolution imaging of deep brain stimulation at 3T

可重构 MRI 技术，可在 3T 下对深部脑刺激进行安全且高分辨率的成像

基本信息

批准号：
10654726
负责人：
Laleh Golestani Rad
金额：
$ 52.64万
依托单位：
NORTHWESTERN UNIVERSITY AT CHICAGO
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-07-15 至 2025-03-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10654726
关键词：
Acceleration Alzheimer&apos s Disease Anatomy Area Brain Cell Nucleus Cephalic Cerebrum Characteristics Clinical Management Clinical Trials Cognition Disorders Computer Assisted Computer Models Coupling Deep Brain Stimulation Development Device Safety Devices Disease Electrodes Engineering Epilepsy Failure Feasibility Studies Fever Friends Functional Imaging Functional Magnetic Resonance Imaging Goals Guidelines Hand Head Heating Image Imaging Techniques Implant Implanted Electrodes Individual Industry Knowledge Lead Location Magnetic Resonance Imaging Major Depressive Disorder Mechanics Methodology Modification Monitor Mood Disorders Morphologic artifacts Movement Disorders Neurophysiology - biologic function Neurosurgical Procedures Operative Surgical Procedures Parkinson Disease Patients Physiologic pulse Pilot Projects Positioning Attribute Protocols documentation Randomized Reproducibility Resolution Risk Rotation Safety Scientist Structure Techniques Technology Testing Therapeutic Tissues Variant Visualization Work chronic pain clinical application deep brain stimulation array deep field survey design electric field high resolution imaging implantable device implantation improved individual patient innovation instrumentation lead optimization millimeter neuroimaging neuroregulation neurosurgery next generation novel radio frequency response safety assessment side effect simulation soft tissue standard care standard of care structural imaging success temporal measurement transmission process

项目摘要

Project Summary Deep brain stimulation (DBS) is a neurosurgical procedure that involves implanting electrodes into specific areas within the brain and delivering constant or intermittent electric pulses from an implanted pulse generator (IPG) to modulate neural function. DBS is the gold standard treatment for Parkinson’s disease, and has shown promise in treating other disorders, most notably chronic pain, epilepsy, major depression, and Alzheimer’s disease. Magnetic resonance imaging (MRI) is extremely useful in patients with DBS implants, as it can provide information on precise location of implanted electrodes and functional response to stimulation. Unfortunately, the interaction of radiofrequency (RF) fields generated by MRI scanners with the leads of DBS devices can trigger potentially fatal RF heating within the tissue. This means that current MRI technology is inaccessible to most patients with DBS implants, presenting a significant barrier to progress in the field of DBS therapeutics. This project seeks to develop novel MRI methodologies alongside DBS implantation techniques that together will make cutting-edge MRI technology fully compatible with implanted DBS devices. Here, this two-pronged approach takes the form of (1) building on our recently introduced concept of reconfigurable MRI technology; and (2) establishing surgical guidelines specific to DBS device implantation. Reconfigurable MRI technology is based on the idea that through innovative engineering we can control local electric fields generated by MR on a patient-by-patient basis, thus avoiding interactions with an implanted device, wherever it happens to be. Part and parcel with engineering-based solutions, we recognize the importance of DBS device lead placement in optimizing the success of the reconfigurable MRI approach. Although RF heating depends exquisitely on lead-trajectory, surgical guidelines are completely silent as to how to best place the extracranial portion of the leads. This in turn leads to arbitrary (and highly variable) lead positioning, which can make RF heating unpredictable even when using reconfigurable technology. Thus, we propose work to develop and validate novel MR technology (Aim 1), intra-surgical implantation strategies (Aim 2), and simulation-based, patient-specific approaches to defining safe imaging parameters (Aim 3). Together, these efforts will eliminate RF heating, reduce image artifact, and support the use of next generation MRI in patients with DBS implants. Our team includes experts in MRI hardware development and instrumentation, MRI computational modeling and safety assessment, FDA regulatory scientists, DBS clinical management and neurosurgery, as well as collaborators from DBS device industry. If successful, we will bring state-of-the-art 3T MRI to DBS patients in its full capacity. This will allow for methodical analysis of DBS parameters/targets in emerging applications, improve our understanding of DBS in existing indications, and bring standard-of-care imaging to patients with existing DBS implants.

项目概要深部脑刺激 (DBS) 是一种神经外科手术，涉及将电极植入特定区域在大脑内并从植入的脉冲发生器 (IPG) 发出持续或间歇的电脉冲调节神经功能的 DBS 是治疗帕金森病的黄金标准，并且已显示出前景。治疗其他疾病，尤其是慢性疼痛、癫痫、重度抑郁症和阿尔茨海默病。磁共振成像 (MRI) 对于接受 DBS 植入的患者非常有用，因为它可以提供不幸的是，有关植入电极的精确位置和对刺激的功能反应的信息。 MRI 扫描仪产生的射频 (RF) 场与 DBS 设备引线的相互作用可以触发组织内潜在致命的射频加热，这意味着当前的 MRI 技术无法实现。大多数患者接受 DBS 植入，这对 DBS 治疗领域的进展构成了重大障碍。该项目旨在开发新颖的 MRI 方法和 DBS 植入技术，将使尖端的MRI技术与植入的DBS设备完全兼容。这里，这两个方面。方法采用以下形式：（1）建立在我们最近引入的可重构 MRI 技术概念的基础上； (2) 制定针对 DBS 装置植入的手术指南。可重构 MRI 技术基于这样的理念：通过创新工程，我们可以控制局部 MR 在每个患者的基础上产生电场，从而避免与植入设备的相互作用，无论它发生在哪里，我们都认识到基于工程的解决方案的重要性。 DBS 设备在优化可重构 MRI 方法中的领先地位尽管射频加热。完全取决于引线轨迹，手术指南完全没有提及如何最好地放置引线这反过来又导致任意（且高度可变）的引线定位，这可以即使使用可重构技术，射频加热也变得不可预测。因此，我们建议开展工作。并验证新颖的 MR 技术（目标 1）、手术内植入策略（目标 2）以及基于模拟的、定义安全成像参数的针对患者的特定方法（目标 3）将共同消除。射频加热，减少图像伪影，并支持在接受 DBS 植入的患者中使用下一代 MRI。我们的团队包括 MRI 硬件开发和仪器、MRI 计算建模和安全评估、FDA 监管科学家、DBS 临床管理和神经外科，以及 DBS 设备行业的合作者如果成功，我们将为 DBS 患者带来最先进的 3T MRI。这将允许对新兴应用中的 DBS 参数/目标进行系统分析，提高我们对现有适应症的 DBS 的理解，并为患有以下疾病的患者带来标准护理成像现有的 DBS 植入物。

项目成果

期刊论文数量（13）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Analysis of the intended and actual orientations of directional deep brain stimulation leads across deep brain stimulation systems.

对定向深部脑刺激的预期和实际方向的分析引导深部脑刺激系统。

DOI：
发表时间：
2022-07
期刊：
影响因子：
0
作者：
Henry, Kaylee R;Miulli, Milina M;Elahi, Behzad;Rosenow, Joshua;Nolt, Mark;Golestanirad, Laleh
通讯作者：
Golestanirad, Laleh

True location of deep brain stimulation electrodes differs from what is seen on postoperative magnetic resonance images: An anthropomorphic phantom study.

深部脑刺激电极的真实位置与术后磁共振图像上看到的不同：一项拟人化模型研究。

DOI：
发表时间：
2022-07
期刊：
影响因子：
0
作者：
Nuzov, Noa B;Bhusal, Bhumi;Henry, Kaylee R;Jiang, Fuchang;Rosenow, Joshua;Elahi, Behzad;Golestanirad, Laleh
通讯作者：
Golestanirad, Laleh

Variations in Determining Actual Orientations of Segmented Deep Brain Stimulation Leads Using the DiODe Algorithm: A Retrospective Study Across Different Lead Designs and Medical Institutions.

使用 DiODe 算法确定分段深部脑刺激导线实际方向的变化：针对不同导线设计和医疗机构的回顾性研究。

DOI：
发表时间：
2023
期刊：
影响因子：
1.7
作者：
Henry, Kaylee R;Miulli, Milina Michelle;Nuzov, Noa B;Nolt, Mark J;Rosenow, Joshua M;Elahi, Behzad;Pilitsis, Julie;Golestanirad, Laleh
通讯作者：
Golestanirad, Laleh

Artifacts Can Be Deceiving: The Actual Location of Deep Brain Stimulation Electrodes Differs from the Artifact Seen on Magnetic Resonance Images.

伪影可能具有欺骗性：深部脑刺激电极的实际位置与磁共振图像上看到的伪影不同。

DOI：
发表时间：
2023
期刊：
影响因子：
1.7
作者：
Nuzov, Noa B;Bhusal, Bhumi;Henry, Kaylee R;Jiang, Fuchang;Vu, Jasmine;Rosenow, Joshua M;Pilitsis, Julie G;Elahi, Behzad;Golestanirad, Laleh
通讯作者：
Golestanirad, Laleh

Effect of surgical modification of deep brain stimulation lead trajectories on radiofrequency heating during MRI at 3T: from phantom experiments to clinical implementation.

深部脑刺激引线轨迹的手术修改对 3T MRI 期间射频加热的影响：从模型实验到临床实施。