ESTABLISH & MAINTAIN CHIMP BIOMEDICAL RES COLONY: THERAPEUTIC AGENT DVMT

建立

• 批准号: 7724650
• 负责人: CHRISTIAN R ABEE
• 金额: $ 71.68万
• 依托单位: UNIVERSITY OF TX MD ANDERSON CAN CTR
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-01 至 2009-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7724650
• 关键词: Acquired Immunodeficiency Syndrome; Age; Awareness; Biohazardous Substance; Biomedical Research; Breeding; Cancer Center; Caring; Charge; Clinical Pathology; Clinical Trials; Complement; Computer Retrieval of Information on Scientific Projects Database; Country; Doctor of Medicine; Equilibrium; Funding; Genetic; Grant; Habitats; Health; Health Services Research; Housing; Human Resources; Individual; Institution; Investigation; Mission; Modeling; Numbers; Pan Genus; Pan troglodytes; Peer Review; Personal Satisfaction; Pliability; Positive Reinforcements; Procedures; Research; Research Personnel; Research Support; Resources; Source; Therapeutic Agents; Training Technics; U-Series Cooperative Agreements; United States National Institutes of Health; Viral; abstracting; cost effective; design; expectation; experience; improved; molecular array; polyfunctional aziridine; programs; success; veterinary science

DESCRIPTION (provided by applicant): This is a revised competitive renewal application of a cooperative agreement titled the "Chimpanzee Biomedical Research Resource" (CBRP). The CBRP is maintained at the Michale E. Keeling Center for Comparative Medicine and Research (KCCMR) of The UT M. D. Anderson Cancer Center in Bastrop, TX and the Primate Foundation of Arizona (PFA) in Mesa, AZ. The primary activity site is the KCCMR with a colony of 103 chimpanzees. The PFA maintains a colony of 61. The use of two sites provides security against disease outbreaks and natural disasters that could jeopardize the resource. Additionally, PFA maintains the only research naive chimpanzee research resource in the US. With recent scientific advances such as the publication of the initial sequence of the chimpanzee genome, it has been determined with certainty that chimpanzees share more than 98% of our DNA and almost all of our genes. The CBRP is one of only four NCRR-supported centers with the capability to conduct biomedical research in this species. Over the past 30years, the CBRP has developed the highly specialized housing facilities, laboratories, management techniques and staff essential for conducting research using chimpanzees. Historically, the CBRP's efforts were focused on colony care and maintenance. Although this remains a primary objective, this revised renewal application presents a new approach that will enhance the research value of chimpanzees. We will expand activities to include the development of a website with information to help scientists determine if the chimpanzee is a relevant model for their studies. We will also make available chimpanzee-derived cell lines, antibodies and other biological materials, and establish a registry of biologic reagents that are known to work in the chimpanzee. Resource-related research will characterize the immune system of the chimpanzee, expand our understanding of chimpanzee cardiomyopathy as a potential disease model, and compare the physiologic and immunologic consequences of research manipulations on chimpanzees trained to voluntarily cooperate with research procedures versus untrained chimpanzees that must be anesthetized. We will accomplish these goals while implementing a new business plan aimed at reducing NCRR core support. By expanding the resources available, conducting resource-related research, and containing cost, the CBRP will provide a critically important, highly specialized, research resource to address human health issues.

描述（由申请人提供）：这是一项名为“黑猩猩生物医学研究资源”（CBRP）的合作协议的竞争更新应用。 CBRP维持在德克萨斯州Bastrop的UT M. D. Anderson癌症中心的Michale E. Keeling比较医学与研究中心（KCCMR）和亚利桑那州梅萨的亚利桑那州灵长类动物基金会（PFA）。主要活动位点是KCCMR，菌落为103黑猩猩。 PFA的殖民地为61。使用两个地点为疾病暴发和自然灾害提供了安全性，这些灾难可能危及资源。此外，PFA维护了美国唯一的幼稚黑猩猩研究资源。随着最近的科学进步，例如出版了黑猩猩基因组的初始顺序，可以肯定地确定黑猩猩共享我们的DNA和几乎所有基因的98％以上。 CBRP是仅有的四个NCRR支持的中心之一，能够在该物种中进行生物医学研究。在过去的30年中，CBRP开发了高度专业化的住房设施，实验室，管理技术和员工，对于使用黑猩猩进行研究至关重要。从历史上看，CBRP的努力集中在殖民地护理和维护上。尽管这仍然是一个主要目标，但此修订后的续订应用程序提出了一种新方法，可以提高黑猩猩的研究价值。我们将扩大活动，包括开发网站，并提供信息，以帮助科学家确定黑猩猩是否是其研究的相关模型。我们还将提供黑猩猩衍生的细胞系，抗体和其他生物学材料，并建立在黑猩猩可以使用的生物学试剂注册处。与资源相关的研究将表征黑猩猩的免疫系统，扩展我们对黑猩猩心肌病的理解为一种潜在的疾病模型，并比较研究操纵对黑猩猩的生理和免疫学后果，该研究对黑猩猩进行了训练，该培训培训了，该培训可以自愿合作，以研究程序与未经特征性的黑猩猩相对于不受欢迎的小动物。我们将实现这些目标，同时实施旨在减少NCRR核心支持的新业务计划。通过扩大可用资源，进行与资源相关的研究以及包含成本，CBRP将提供至关重要的，高度专业化的研究资源来解决人类健康问题。