Structural Biology - Bjorkman, Chair

结构生物学 - Bjorkman，主席

• 批准号: 7747568
• 负责人: ANDREW D ROBERTSON
• 金额: $ 1万
• 依托单位: KEYSTONE SYMPOSIA
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-30 至 2010-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7747568
• 关键词: Binding; Biological; Cells; Colorado; Complex; Development; Disease; Growth; Human; In Situ; In Vitro; Individual; Molecular; Molecular Conformation; Nucleic Acids; Proteins; Source; Specific qualifier value; Staging; Structure; System; base; cofactor; frontier; insight; macromolecule; meetings; novel therapeutic intervention; public health relevance; small molecule; structural biology; structural genomics; symposium

DESCRIPTION (provided by applicant): This proposal is to request support for a Keystone Symposia meeting entitled "Structural Biology", organized by Pamela J. Bjorkman and Andrej Sali, which will be held in Breckenridge, Colorado from January 8 - 13, 2010. Static depictions are appearing in ever-increasing numbers of the detailed structures of individual macromolecules. A key challenge for structural biology is how to parlay this reservoir of fundamental information into a comparably detailed understanding of how functional complexes assemble; what ranges of alternative conformations they may assume at successive stages of their functional cycles; how they recognize each other; and how their propensities to bind small molecules, cofactors and other macromolecules are specified; and how they behave in cells. This meeting will explore ongoing developments in structural biology on several fronts including the following: the frontier between in vitro and in situ observations; the frontier between traditional experimental approaches and newly emerging complementary ones; and the frontier represented by computational structural biology as a means to analyze, integrate, and unify information emerging from diverse experimental sources. Opportunities for interdisciplinary interactions will be further enhanced by the concurrent meeting "Structural Genomics: Expanding the Horizons of Structural Biology", which will share the opening keynote session and two plenary sessions with this meeting. PUBLIC HEALTH RELEVANCE: There has been an explosive growth in the amount of structural information available on macromolecular systems such as proteins, nucleic acids, and their complexes. These insights and those derived from complementary studies are proving important for understanding the molecular basis for diseases and for the development of new therapeutic approaches to treating human disorders. The Keystone Symposia meeting on Structural Biology will focus on recent developments in structural biology and their impact on the understanding of key biological problems.

描述（由申请人提供）：该建议是为了支持由Pamela J. Bjorkman和Andrej Sali组织的Keystone研讨会会议，题为“结构生物学”，该会议将于2010年1月8日至13日在科罗拉多州的Breckenridge举行。结构生物学的一个关键挑战是如何将基本信息的这种储层变成对功能复合物如何组装方式的详细理解。他们在功能周期的连续阶段可能会假设的替代构象的范围；他们如何认识彼此；以及如何指定它们结合小分子，辅助因子和其他大分子的倾向；以及它们在细胞中的行为。这次会议将在几个方面探索结构生物学的持续发展，包括以下几个方面：体外和原位观察之间的边界；传统实验方法与新出现的互补方法之间的前沿；以及以计算结构生物学为代表的边界作为分析，整合和统一来自各种实验来源的信息的手段。并发会议“结构性基因组学：扩大结构生物学的视野”将进一步增强跨学科互动的机会，该会议将共享开幕主题演讲和两次全体会议。 公共卫生相关性：在大分子系统（例如蛋白质，核酸及其复合物）上可用的结构信息量爆炸性增长。这些见解和从互补研究中得出的见解对于理解疾病的分子基础以及开发新的治疗人类疾病的治疗方法很重要。 Keystone研讨会关于结构生物学的会议将重点关注结构生物学的最新发展及其对关键生物学问题的理解的影响。