Cocaine use, viral suppression and precursors of stroke in HIV infection

HIV 感染中的可卡因使用、病毒抑制和中风前兆

基本信息

批准号：
10604342
负责人：
ELISE D. RILEY
金额：
$ 80.73万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-06-01 至 2025-04-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10604342
关键词：
Acute Address Age Alcohols Amphetamines Biological Markers C-reactive protein CD4 Lymphocyte Count Cannabis Cardiovascular Diseases Chronic Clinic Clinical Cocaine Cocaine use disorder Communities Data Detection Diagnosis Drug abuse Drug usage Failure Functional disorder Goals HIV HIV Infections HIV/AIDS Homelessness Individual Infarction Inflammation Inflammatory Levamisole Lidocaine Link Low Income Population Magnetic Resonance Imaging Measures Methadone Microvascular Dysfunction Modernization Opioid Opioid Analgesics Pathway interactions Patient Recruitments Patient Self-Report Persons Pharmaceutical Preparations Pilot Projects Preventive Reaction Recording of previous events Research Risk Risk Assessment Risk Factors Stroke Time Tobacco Tobacco use Toxicology Viral Viral Load result Woman amphetamine use antiretroviral therapy cardiovascular disorder risk cardiovascular risk factor cerebrovascular cocaethylene cocaine use disability high risk housing instability improved inflammatory marker insight mortality multiple drug use polysubstance use predictive marker recruit response risk stratification safety net stroke risk stroke-like episode substance use tool

项目摘要

PROJECT SUMMARY/ABSTRACT Stroke is a major cause of disability and mortality, particularly in low-income individuals and people living with HIV (PLWH). It is associated with a variety of substances, including amphetamines, opiates, cannabis, alcohol, tobacco, and especially cocaine. However, most stroke studies do not account for drug use outside of alcohol or tobacco, and substance use is not included in stroke risk calculators. Our preliminary data suggest that cocaine use may influence mechanisms of stroke. If true, the consideration of cocaine use in stroke risk calculators could greatly improve risk assessment in PLWH who use drugs. We propose a new study to assess whether cocaine and polydrug use, in combination with inflammation, are significantly associated with stroke and mechanisms of stroke. The study will be one of very few to recruit participants from both safety net HIV clinics and community-based settings. It will provide much needed information regarding factors that influence conditions preceding stroke in PLWH who use drugs.

项目摘要/摘要中风是残疾和死亡率的主要原因，尤其是在低收入个人中患有艾滋病毒（PLWH）的人。它与多种物质有关，包括苯丙胺，阿片类药物，大麻，酒精，烟草，尤其是可卡因。但是，大多数中风研究不考虑酒精或烟草之外的药物使用，并且使用物质是不包括中风风险计算器。我们的初步数据表明可卡因的使用可能影响中风的机制。如果是真的，请考虑可卡因在中风风险中使用计算器可以大大改善使用药物的PLWH的风险评估。我们提出了一个新的评估可卡因和多药的研究是否与炎症结合使用是与中风和中风机制显着相关。这项研究将是极少数从安全网艾滋病毒诊所和基于社区的环境中招募参与者。会提供有关影响中风前状况的因素的急需信息使用毒品的PLWH。

项目成果

期刊论文数量（7）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Using a "Big Events" framework to understand emergency department use among women experiencing homelessness or housing instability in San Francisco during the COVID-19 pandemic.

DOI：
10.1016/j.drugpo.2021.103405
发表时间：
2021-11
期刊：
The International journal on drug policy
影响因子：
0
作者：
Riley ED;Raven MC;Dilworth SE;Braun C;Imbert E;Doran KM
通讯作者：
Doran KM

Impact of multiple substance use on circulating ST2, a biomarker of adverse cardiac remodelling, in women.

DOI：
10.1080/1354750x.2022.2129451
发表时间：
2022-12
期刊：
BIOMARKERS
影响因子：
2.6
作者：
Riley, Elise D.;Kazi, Dhruv S.;Coffin, Phillip O.;Vittinghoff, Eric;Wade, Amanda N.;Bulfone, Tommaso C.;Lynch, Kara L.;Atai, Zahra;Wu, Alan H. B.
通讯作者：
Wu, Alan H. B.

Loss of Essential Resources During the COVID-19 Pandemic Among Unsheltered and Unstably Housed Women.

DOI：
10.1007/s11606-021-07288-1
发表时间：
2022-03
期刊：
Journal of general internal medicine
影响因子：
5.7
作者：
Braun C;Wade AN;Weiser SD;Riley ED
通讯作者：
Riley ED

Cocaine Use and White Matter Hyperintensities in Homeless and Unstably Housed Women.

DOI：
10.1016/j.jstrokecerebrovasdis.2021.105675
发表时间：
2021-05
期刊：
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association
影响因子：
0
作者：
Riley ED;Chow FC;Josephson SA;Dilworth SE;Lynch KL;Wade AN;Braun C;Hess CP
通讯作者：
Hess CP

Multiple substance use, inflammation and cardiac stretch in women living with HIV.

DOI：
10.1016/j.drugalcdep.2022.109564
发表时间：
2022-09-01
期刊：
DRUG AND ALCOHOL DEPENDENCE
影响因子：
4.2
作者：
Riley, Elise D.;Kizer, Jorge R.;Tien, Phyllis C.;Vittinghoff, Eric;Lynch, Kara L.;Wu, Alan H. B.;Coffin, Phillip O.;Beck-Engeser, Gabriele;Braun, Carl;Hunt, Peter W.
通讯作者：
Hunt, Peter W.