Mentoring patient-oriented research on the health consequences of polydrug use

指导以患者为中心的关于多种药物使用的健康后果的研究

• 批准号: 10661513
• 负责人: ELISE D. RILEY
• 金额: $ 18.83万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-07-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10661513
• 关键词: Acquired Immunodeficiency Syndrome; Address; Age; Alcohols; Attention; Biological Markers; Blood; Body mass index; CD4 Lymphocyte Count; California; Cannabis; Catabolism; Cerebrovascular Disorders; Cessation of life; Clinical; Cocaine; Cocaine use disorder; Communicable Diseases; Complement; Consequences of HIV; Data; Drug Combinations; Drug usage; Environment; Enzymes; Epidemiologist; Failure; Functional disorder; Funding; Goals; HIV; HIV Infections; Health; Healthcare; Immune System Diseases; Individual; Infarction; Inflammation; Inflammatory; Interview; Investigation; Knowledge; Kynurenine; Learning; Link; Low Income Population; Magnetic Resonance Imaging; Measures; Medicine; Mentors; Microvascular Dysfunction; Modernization; National Institute of Drug Abuse; Opioid; Opioid Analgesics; Parents; Pathway interactions; Persons; Pharmaceutical Preparations; Physiological; Postdoctoral Fellow; Recommendation; Research; Research Personnel; Research Project Grants; Risk; Risk Assessment; San Francisco; Science; Stroke; T-Cell Proliferation; Time; Tobacco; Toxicology; Training; Tryptophan; Tryptophan 2,3 Dioxygenase; Universities; Viral; Viral Load result; Visit; Woman; amphetamine use; antiretroviral therapy; cardiovascular risk factor; career; career development; cerebrovascular; clinical development; cocaine use; cost effective; early-career faculty; experience; improved; inflammatory marker; insight; interest; mortality; multiple drug use; patient oriented research; polysubstance use; premature; professor; programs; public health relevance; recruit; research and development; response; risk stratification; skills; stroke risk; tool; training opportunity; virtual; Acquired Immunodeficiency Syndrome; Address; Age; Alcohols; Attention; Biological Markers; Blood; Body mass index; CD4 Lymphocyte Count; California; Cannabis; Catabolism; Cerebrovascular Disorders; Cessation of life; Clinical; Cocaine; Cocaine use disorder; Communicable Diseases; Complement; Consequences of HIV; Data; Drug Combinations; Drug usage; Environment; Enzymes; Epidemiologist; Failure; Functional disorder; Funding; Goals; HIV; HIV Infections; Health; Healthcare; Immune System Diseases; Individual; Infarction; Inflammation; Inflammatory; Interview; Investigation; Knowledge; Kynurenine; Learning; Link; Low Income Population; Magnetic Resonance Imaging; Measures; Medicine; Mentors; Microvascular Dysfunction; Modernization; National Institute of Drug Abuse; Opioid; Opioid Analgesics; Parents; Pathway interactions; Persons; Pharmaceutical Preparations; Physiological; Postdoctoral Fellow; Recommendation; Research; Research Personnel; Research Project Grants; Risk; Risk Assessment; San Francisco; Science; Stroke; T-Cell Proliferation; Time; Tobacco; Toxicology; Training; Tryptophan; Tryptophan 2,3 Dioxygenase; Universities; Viral; Viral Load result; Visit; Woman; amphetamine use; antiretroviral therapy; cardiovascular risk factor; career; career development; cerebrovascular; clinical development; cocaine use; cost effective; early-career faculty; experience; improved; inflammatory marker; insight; interest; mortality; multiple drug use; patient oriented research; polysubstance use; premature; professor; programs; public health relevance; recruit; research and development; response; risk stratification; skills; stroke risk; tool; training opportunity; virtual

ABSTRACT Dr. Elise Riley is a Professor in the Division of HIV, Infectious Diseases and Global Medicine at the University of California, San Francisco. Trained as an epidemiologist, she has mentored 57 postdoctoral fellows and early-career faculty throughout her career while simultaneously leading research focused on the health consequences of HIV and drug use. She is currently funded by NIDA to conduct a study regarding the influences of polydrug use, viral load and inflammation on small vessel disease in people living with HIV. Here she proposes an expansion of the parent study to include measures of tryptophan catabolism, which will provide a better understanding of cerebrovascular dysfunction through the consideration of multiple physiological pathways. Within this expanded investigation, Dr. Riley will continue growing and improving the content of her individual-level mentoring program. In parallel, she will partner with the UCSF Center for AIDS Research (CFAR) to create a new virtual mentoring module within the existing CFAR mentoring program. In combination, the proposed activities will provide multiple opportunities for training in patient-oriented research and career development for early career investigators.

抽象的 Elise Riley博士是艾滋病毒，传染病和全球医学的教授 加利福尼亚大学旧金山。她曾被培训为流行病学家，她曾指导过57 博士后研究员和早期职业教师在她的整个职业生涯中同时领导 研究着重于艾滋病毒和吸毒的健康后果。她目前由 NIDA进行有关多药物使用，病毒载荷和炎症影响的研究 关于艾滋病毒患者的小血管疾病。她在这里提出了扩展 父母研究包括色氨酸分解代谢的度量，这将提供更好的 通过考虑多个的理解脑血管功能障碍 生理途径。在这项扩展的调查中，赖利博士将继续增长， 改善其个人级别指导计划的内容。她将与她合作 UCSF艾滋病研究中心（CFAR），以创建一个新的虚拟指导模块 现有的CFAR指导计划。结合起来，拟议的活动将提供 早期以患者为导向的研究和职业发展进行培训的许多机会 职业调查人员。