Cocaine use, viral suppression and precursors of stroke in HIV infection

HIV 感染中的可卡因使用、病毒抑制和中风前兆

基本信息

批准号：
10005804
负责人：
ELISE D. RILEY
金额：
$ 80.57万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-06-01 至 2025-04-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10005804
关键词：
AIDS/HIV problem Acute Address Age Alcohol consumption Alcohol or Other Drugs use Alcohols Amphetamines Biological Markers C-reactive protein CD4 Lymphocyte Count Cannabis Cardiovascular Diseases Chronic Clinic Clinical Cocaine Communities Data Detection Diagnosis Disease Drug abuse Drug usage Failure Functional disorder Goals HIV HIV Infections Homelessness Individual Infarction Inflammation Inflammatory Levamisole Lidocaine Link Low Income Population Low income Magnetic Resonance Imaging Measures Methadone Microvascular Dysfunction Modernization Opioid Opioid Analgesics Pathway interactions Patient Recruitments Patient Self-Report Persons Pharmaceutical Preparations Pilot Projects Preventive Recording of previous events Research Risk Risk Assessment Risk Factors Risk stratification Stroke Time Tobacco Tobacco use Toxicology Viral Viral Load result Woman amphetamine use antiretroviral therapy base cardiovascular disorder risk cardiovascular risk factor cerebrovascular cocaethylene cocaine use disability high risk housing instability improved inflammatory marker insight mortality predictive marker recruit response safety net stroke risk stroke-like episode tool

项目摘要

PROJECT SUMMARY/ABSTRACT Stroke is a major cause of disability and mortality, particularly in low-income individuals and people living with HIV (PLWH). It is associated with a variety of substances, including amphetamines, opiates, cannabis, alcohol, tobacco, and especially cocaine. However, most stroke studies do not account for drug use outside of alcohol or tobacco, and substance use is not included in stroke risk calculators. Our preliminary data suggest that cocaine use may influence mechanisms of stroke. If true, the consideration of cocaine use in stroke risk calculators could greatly improve risk assessment in PLWH who use drugs. We propose a new study to assess whether cocaine and polydrug use, in combination with inflammation, are significantly associated with stroke and mechanisms of stroke. The study will be one of very few to recruit participants from both safety net HIV clinics and community-based settings. It will provide much needed information regarding factors that influence conditions preceding stroke in PLWH who use drugs.

项目摘要/摘要中风是残疾和死亡率的主要原因，尤其是在低收入个人中患有艾滋病毒（PLWH）的人。它与多种物质有关，包括苯丙胺，阿片类药物，大麻，酒精，烟草，尤其是可卡因。但是，大多数中风研究不考虑酒精或烟草之外的药物使用，并且使用物质是不包括中风风险计算器。我们的初步数据表明可卡因的使用可能影响中风的机制。如果是真的，请考虑可卡因在中风风险中使用计算器可以大大改善使用药物的PLWH的风险评估。我们提出了一个新的评估可卡因和多药的研究是否与炎症结合使用是与中风和中风机制显着相关。这项研究将是极少数从安全网艾滋病毒诊所和基于社区的环境中招募参与者。会提供有关影响中风前状况的因素的急需信息使用毒品的PLWH。