Quantitative Analysis of Cancer-associated EVs

癌症相关 EV 的定量分析

• 批准号: 10604126
• 负责人: JOHN P NOLAN
• 金额: $ 100.83万
• 依托单位: CELLARCUS BIOSCIENCES INC
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-06-09 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10604126
• 关键词: Antibodies; Antibody Affinity; Antibody Specificity; Automation; Biogenesis; Biological Assay; Biological Markers; Biological Process; Biological Sciences; Biotechnology; Blood; Brain; Cancerous; Cell Line; Cells; Cerebrospinal Fluid; Client; Collaborations; Color; Complex; Controlled Environment; Cryoelectron Microscopy; Data; Development; Diagnosis; Distant; Engineering; Feedback; Flow Cytometry; Fluorescent Antibody Technique; Heterogeneity; Immunoassay; Laboratories; Malignant Neoplasms; Measurement; Measures; Medical center; Membrane Proteins; Methods; Monitor; Monoclonal Antibodies; Neoplasm Metastasis; Optics; Organ; Pathology; Performance; Phase; Plasma; Preparation; Production; Reagent; Recurrence; Reporting; Reproducibility; Research; Research Personnel; Resolution; Role; Sampling; Services; Site; Standardization; Surface; Technology; Test Result; Testing; Time; Tissues; Tumor Markers; Urine; Validation; Vesicle; Work; biomarker panel; cancer type; design; detection limit; diagnostic biomarker; extracellular vesicles; improved; interest; liquid biopsy; neoplastic cell; potential biomarker; response; therapeutic biomarker; tool; tumor progression; vesicular release

Abstract All cells in the body, including tumor cells, release small vesicles that can be found in blood, cerebrospinal fluid, and even urine. Because each vesicle was released by a specific cell, their analysis can tell us about the cells from which they came, including whether that cell was infected, cancerous, or malfunctioning in some way. We will develop assays and kits to enable cancer researchers to analyze these vesicles to improve the ability to understand, detect and treat cancer.

抽象的 人体中的所有细胞，包括肿瘤细胞，都释放出可以在血液中发现的小囊泡， 脑脊液，甚至尿液。因为每个囊泡都是由特定细胞释放的，所以 分析可以告诉我们它们来自的细胞，包括该单元是否是 以某种方式感染，癌性或故障。我们将开发测定和套件以启用 癌症研究人员分析这些囊泡，以提高理解，检测和 治疗癌症。