Identification of Cell Type-specific EVs for Neuroscience Research

用于神经科学研究的细胞类型特异性 EV 的鉴定

• 批准号: 9915908
• 负责人: JOHN P NOLAN
• 金额: $ 69.54万
• 依托单位: CELLARCUS BIOSCIENCES INC
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-04-15 至 2022-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9915908
• 关键词: Alzheimer' s Disease; Antibodies; Antibody Affinity; Antibody Specificity; Automation; Biological Assay; Biological Markers; Biological Sciences; Biotechnology; Blood; Boston; Brain; Cancerous; Cell Line; Cells; Cerebrospinal Fluid; Client; Collaborations; Color; Complex; Controlled Environment; Data; Detection; Diagnosis; Disease; Distant; Engineering; Feedback; Flow Cytometry; Fluorescent Antibody Technique; Heterogeneity; Immunoassay; Laboratories; Measurement; Measures; Membrane Proteins; Methods; Monoclonal Antibodies; Neurons; Neurosciences Research; Optics; Organ; Parkinson Disease; Performance; Phase; Plasma; Preparation; Production; Protocols documentation; Reagent; Reporting; Reproducibility; Research Personnel; Resolution; Role; Sampling; Services; Site; Standardization; Substance Use Disorder; Surface; Technology; Test Result; Testing; Time; Tissues; Training; Travel; Urine; Validation; Vesicle; biomarker panel; brain cell; cell type; design; extracellular vesicles; improved; instrument; interest; liquid biopsy; nervous system disorder; neurophysiology; potential biomarker; prevent; reagent standard; tool; vesicular release

Abstract All cells in the body, including brain cells, release small vesicles that can be found in blood, cerebrospinal fluid, and even urine. Because each vesicle was released by a specific cell, their analysis can tell us about the cells from which they came, including whether that cell was infected, cancerous, or malfunctioning in some way. We will produce tools to analyze these vesicles to improve the ability to detect, treat, and prevent disease.

抽象的 体内的所有细胞，包括脑细胞，都会释放出血液中的小囊泡， 脑脊液，甚至尿液。因为每个囊泡都是由特定的细胞释放的，所以它们的 分析可以告诉我们它们来自哪些细胞，包括该细胞是否是 感染、癌变或以某种方式出现故障。我们将开发工具来分析这些 囊泡以提高检测、治疗和预防疾病的能力。