Personalized Strategies for Periodontal Tissue Regeneration - A Converged Biofabrication Approach

牙周组织再生的个性化策略——融合生物制造方法

基本信息

批准号：
10390983
负责人：
Marco C Bottino
金额：
$ 51.51万
依托单位：
UNIVERSITY OF MICHIGAN AT ANN ARBOR
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-08-01 至 2027-04-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10390983
关键词：
3-Dimensional Address Adopted Affect American Animal Model Architecture Bacteria Biocompatible Materials Biological Process Bone Growth Ceramics Chemicals Chronic Clinical Data Defect Dental Cementum Dentition Development Disease Engineering Fiber Genes Goals Growth and Development function In Vitro Inflammatory Ink Lasers Lead Left Magnesium Mechanics Medicine Morphology Mouth Diseases Nanostructures Natural regeneration Nature Patients Periodontal Ligament Periodontic specialty Periodontitis Physiological Plant Roots Polymers Printing Role Savings Silver Structure Surface Technology Therapeutic Tissues Tooth Extraction Tooth Loss Tracheobronchomalacia Translating Translations alveolar bone antimicrobial base biofabrication bone bone engineering bone loss bone scaffold calcium phosphate canine model clinical efficacy clinically relevant design human old age (65+)improved in vivo in vivo Model innovation inorganic phosphate melting novel personalized medicine personalized strategies regenerative therapy scaffold tissue regeneration tool

项目摘要

” Periodontitis (gum disease) is a ubiquitous chronic inflammatory, bacteria-triggered oral disorder affecting two-thirds of Americans over age 65. If left untreated, it leads to severe destruction of the periodontal attachment apparatus, eventually resulting in tooth loss. There are no approaches for predictably regenerating defects with severe bone loss and avoiding tooth extraction. Thus, there is an emerging quest for personalized solutions that can guide coordinated growth and development of the periodontal attachment apparatus. We hypothesize that: (1) Melt ElectroWriting (MEW) is the fabrication tool required to develop a compositionally and structurally tailored, tissue-specific scaffold to hearten bone growth and PDL formation on root surfaces with moderate adjacent bone; and (2) the convergence of MEW with ceramic printing is key to engineering a compositionally graded and structurally tailored scaffold to support bone growth while guiding PDL formation on root surfaces with minimum adjacent bone. Two aims are proposed. Aim 1 will optimize a personalized, compositionally and structurally tailored, tissue-specific polymeric scaffold to regenerate defects with moderate surrounding bone. Aim 2 will develop a personalized, compositionally graded and structurally tailored, tissue-specific multi-material scaffold to regenerate defects with minimum surrounding bone. To expedite translation, we will determine efficacy using our clinically relevant animal models. Successful completion of this project is central to translating personalized therapies to treat tissue destruction caused by periodontitis and thus saving millions of teeth from extraction.

” 牙周炎（牙龈疾病）是一种普遍存在的慢性炎症、细菌引发的口腔疾病，影响三分之二的 65 岁以上美国人。如果不及时治疗，会导致牙周附着装置严重破坏，最终导致牙齿脱落。因此，人们正在寻求能够指导牙周附着装置协调生长和发育的个性化解决方案。熔化电写 (MEW) 是开发成分和结构定制的组织特异性支架所需的制造工具，以促进骨生长和具有适度相邻骨的牙根表面上的 PDL 形成；(2) MEW 与陶瓷打印的融合是关键设计一个成分分级和结构定制的支架，以支持骨骼生长，同时引导 PDL 在根部表面形成，并具有最少的相邻骨骼。目标 1 将优化个性化的、成分和结构定制的、组织特异性的支架。目标 2 将开发一种个性化的、成分分级的、结构定制的、组织特异性的多材料支架，以再生具有最少周围骨骼的缺陷，以加快转化，我们将使用我们的临床相关性来确定疗效。该项目的成功完成对于转化个性化疗法来治疗牙周炎引起的组织破坏至关重要，从而使数百万颗牙齿免于拔除。