UC Davis Chemical Biology Program

加州大学戴维斯分校化学生物学项目

基本信息

批准号：
10618869
负责人：
PETER A. BEAL
金额：
$ 27.13万
依托单位：
UNIVERSITY OF CALIFORNIA AT DAVIS
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-07-01 至 2026-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10618869
关键词：
Biology Chemicals programs

项目摘要

The goal of the UC Davis Chemical Biology Program (CBP) is to provide effective cross training at the chemistry/biology interface for pre-doctoral candidates. After their CBP cross training, these students will understand the value of the synthesis and analysis tools traditionally associated with chemistry in addressing problems related to biological pathways, cells, tissues and organisms with a particular focus on biological questions related to human health. The chemical biology community at UC Davis includes a large group of productive, well funded and collaborative faculty members with a strong history of mentoring pre-doctoral students. The CBP faculty comprises 29 trainers with primary appointments in seven different departments in five different colleges. CBP faculty research programs cover a broad swath of topics (e.g. calcium signaling, glycobiology, metabolic engineering, DNA repair, RNA modification, translation, photoreception, photosynthesis, cancer therapeutics, drug metabolism, metabolomics, molecular imaging and genome editing) using an extensive range of approaches (e.g. genetics, genomics, x-ray crystallography, NMR spectroscopy, EPR spectroscopy, mass spectrometry, combinatorial chemistry, high throughput screening, computational modeling, enzymology and organic synthesis). Trainees will be selected for this program from first year students with an expressed interest in carrying out thesis research at the chemistry/biology interface from five different graduate groups (Chemistry; Biochemistry, Molecular, Cellular and Developmental Biology; Biomedical Engineering; Pharmacology and Toxicology and Biophysics). These students will engage in cross training coursework, cross training laboratory rotations, research-in-progress presentations, career development activities, responsible conduct in research training and annual retreats. This proposal requests support for six predoctoral student slots to support 3-4 trainees for two years each, typically during the second and third years of their PhD training. This support, along with the major institutional commitments made by UC Davis, will establish a predoctoral program that will more effectively prepare our trainees for scientific careers at the chemistry/biology interface.

加州大学戴维斯分校化学生物学计划（CBP）的目标是提供有效的交叉训练在化学/生物学界面上，用于候选前候选者。经过CBP交叉训练，这些学生将传统上了解综合和分析工具的价值与化学有关解决与生物途径，细胞，组织有关的问题相关的以及特别关注与人类健康有关的生物学问题的生物。加州大学戴维斯分校的化学生物学社区包括一大批生产力，资助良好的以及合作的教职员工，拥有指导博士前学生的悠久历史。这 CBP教职员工包括29名在七个不同部门的主要任命的培训师五个不同的大学。 CBP教师研究计划涵盖了广泛的主题（例如钙信号传导，糖脂学，代谢工程，DNA修复，RNA修饰，翻译，光感受，光合作用，癌症治疗学，药物代谢，代谢组学，分子成像和基因组编辑）使用广泛的方法（例如遗传学，基因组学，X射线晶体学，NMR光谱，EPR光谱，质量光谱法，组合化学，高通量筛选，计算建模，酶学和有机合成）。从第一年起，学员将被选为该计划对在化学/生物学进行论文研究表现出兴趣表示兴趣的学生来自五个不同研究生组的界面（化学；生物化学，分子，细胞和发展生物学；生物医学工程；药理学和毒理学以及生物物理学）。这些学生将参加跨培训课程，跨培训实验室轮换，进行研究的演讲，职业发展活动，负责任研究培训和年度务虚会进行。该建议要求支持六个专业的学生老虎机以支持3-4名学员两年，通常在第二个以及他们的博士学位培训的第三年。这种支持，以及主要的机构加州大学戴维斯（UC Davis）做出的承诺将建立一个占主导地位的计划，该计划将更有效在化学/生物学界面上为学员准备科学职业。