Sample Collection Protocols

样本采集协议

• 批准号: 7732755
• 负责人: Barney Scott Graham
• 金额: $ 65.58万
• 依托单位: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7732755
• 关键词: Biological Assay; Biopsy; Blood; Blood Component Removal; Body Fluids; Cells; Clinical; Clinical Trials; Communicable Diseases; Development; Disease; Evaluation; HIV vaccine; Human; Immune; Immune response; Immunity; Laboratories; Measures; Medicine; Mononuclear; Pathogenesis; Plasma; Procedures; Protocols documentation; Purpose; Research; Research Personnel; Sampling; Severity of illness; Skin; Specimen; Support of Research; Swab; Tissues; Transfusion; United States National Institutes of Health; Vaccinated; Validation; Venous blood sampling; Virus Diseases; Work; base; experience; immunogenicity; research study; sample collection; vaccine development; volunteer

The purpose of this project is to collect human specimens, such as blood, mucosal secretions, skin swabs, skin biopsy, or body fluids to support research studies and to validate research assays used in evaluation of clinical trials immunogenicity results. These samples will be used by laboratory researchers in their work on the development of vaccines for HIV and other infectious diseases, to study the correlates of immunity related to infectious diseases and in laboratory work related to the development and/or validation of immunological assays. In order to carry out research studies, it is sometimes necessary to obtain larger quantities of plasma or mononuclear cells than can be safely obtained by simple phlebotomy. These components can be safely obtained using apheresis procedures, which are performed in the NIH Clinical Center Department of Transfusion Medicine (DTM).

该项目的目的是收集人类标本，例如血液，粘膜分泌物，皮肤拭子，皮肤活检或体液，以支持研究研究并验证用于评估临床试验免疫原性结果的研究测定法。实验室研究人员将使用这些样本在开发艾滋病毒和其他传染病的疫苗开发的工作中，研究与传染病有关的免疫相关性以及与免疫学分析的开发和验证有关的实验室工作。 为了进行研究，有时需要获得比简单的静脉切开术安全获得的数量更大的血浆或单核细胞。这些组件可以使用分离术程序安全地获得，该过程是在NIH临床输血医学部（DTM）中进行的。