Cytolytic T Cell Activity In Response To Primary RSV Infection In Mice

小鼠原发性 RSV 感染的溶细胞 T 细胞活性

• 批准号: 7592397
• 负责人: Barney Scott Graham
• 金额: $ 77.5万
• 依托单位: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7592397
• 关键词: CD4 Positive T Lymphocytes; CD8B1 gene; Cells; Child; Cytopathology; Cytotoxic T-Lymphocytes; Disease; IL2RA gene; Immune response; Infant; Lower Respiratory Tract Infection; Mediating; Mus; Regulation; Relative (related person); Respiratory Syncytial Virus Infections; Respiratory syncytial virus; Satellite Viruses; T-Lymphocyte; Viral; Virus; defined contribution; immunopathology; response

Respiratory syncytial virus (RSV) is the leading cause of lower respiratory tract infections in infants and small children. RSV infection is characterized by significant immunopathology, which is mediated by CD8+ cytotoxic T lymphocytes (CTL). Past studies have suggested that the multiple mechanisms employed by CTLs to eliminate cells may have differential effects on viral clearance and RSV-associated illness. This study seeks to define the contributions of the different CTL effector mechanisms and CD25+ T regulatory cells to the clearance of primary RSV infection, as well as their relative impact on the virus-associated immunopathology.

呼吸道合胞病毒（RSV）是婴儿和小儿童下呼吸道感染的主要原因。 RSV感染的特征是显着的免疫病理学，由CD8+细胞毒性T淋巴细胞（CTL）介导。过去的研究表明，CTL用于消除细胞的多种机制可能对病毒清除和与RSV相关的疾病具有不同的影响。这项研究旨在定义不同CTL效应机制和CD25+ T调节细胞对原发性RSV感染的清除的贡献，以及它们对病毒相关免疫病理学的相对影响。