Apheresis Procedures to Obtain Plasma or PBMCs for Resea

获取血浆或 PBMC 用于研究的单采程序

• 批准号: 6822472
• 负责人: Barney Scott Graham
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6822472
• 关键词: HIV infections; cellular immunity; clinical research; data management; human subject; leukapheresis; lymphocyte; plasmapheresis; technology /technique development

This project is a protocol to collect human peripheral blood mononuclear cells (PBMCs) by apheresis to be used for research studies. The VRC is using the sample to study specific immune responses to HIV infection in order to characterize protective responses that can prevent new infection in uninfected individuals, as well as define those responses that lead to successful control of viral replication in persons already infected with HIV. Because of the lack of an adequate animal model it is necessary to utilize human peripheral blood cells. We wish to define the specific human immune responses to HIV infection using human peripheral blood mononuclear cells as a model. This sample collection protocol also supports VRC research on other pathogens and vaccines.

该项目是一种通过放置术来收集人外周血单核细胞（PBMC）的方案，用于研究。 VRC正在使用样品研究对HIV感染的特定免疫反应，以表征可以防止未感染个体的新感染的保护性反应，并定义那些导致已经感染HIV的人成功控制病毒复制的反应。由于缺乏足够的动物模型，因此有必要利用人类外周血细胞。我们希望使用人外周血单核细胞作为模型来定义人类对HIV感染的特定免疫反应。该样本收集方案还支持对其他病原体和疫苗的VRC研究。