Midcareer investigator award in patient-oriented research in the area of perinatal-developmental neuroscience

围产期发育神经科学领域以患者为导向的研究中的职业生涯中期研究员奖

• 批准号: 10472708
• 负责人: Marisa N Spann
• 金额: $ 16.1万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-01 至 2026-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10472708
• 关键词: Age; Anterior; Anxiety; Area; Attention; Autoimmune Diseases; Base of the Brain; Behavior Therapy; Behavioral; Behavioral Symptoms; Biological; Biological Markers; Blood Glucose; Body mass index; Brain; Brain region; Child; Childhood; Cognitive; Computerized Medical Record; Data; Data Collection; Data Pooling; Data Set; Development; Diagnosis; Dimensions; Distress; Dorsal; Early Diagnosis; Ensure; Funding; Funding Mechanisms; Future; Goals; Health; Health education; High Prevalence; Hydrocortisone; Image; Immune system; Infant; Infection; Inflammation; Insula of Reil; International; Intervention; Knowledge; Laboratories; Life Style; Link; Literature; Magnetic Resonance Imaging; Manuscripts; Maps; Medial; Mediating; Medical center; Mental Depression; Mental Health; Mental Health Services; Mental disorders; Mentors; Mentorship; Midcareer Investigator Award in Patient-Oriented Research; Mothers; National Institute of Child Health and Human Development; National Institute of Mental Health; Neonatal; Neurobiology; Neurosciences; Obesity; Outcome; Pathway interactions; Perinatal; Pilot Projects; Positioning Attribute; Prefrontal Cortex; Pregnancy; Pregnant Women; Procedures; Productivity; Program Development; Public Health; Regulation; Research; Research Domain Criteria; Research Personnel; Research Training; Resources; Risk; Rodent Model; Role; Salivary; Sampling; School-Age Population; Science; Scientist; Series; Stress; Structure; Symptoms; Thalamic structure; Time; Toddler; Training; Training Activity; Training Programs; Training Support; United States National Institutes of Health; Universities; Work; advanced analytics; analytical method; antepartum depression; brain morphology; brain pathway; brain volume; career; career development; career networking; cingulate cortex; cohort; diabetes risk; environmental stressor; experience; fetal; health information technology; human model; hypothalamic-pituitary-adrenal axis; improved; indexing; interest; intergenerational; maternal depression; neuroimaging; next generation; obesity risk; offspring; patient oriented; patient oriented research; patient population; personalized approach; prenatal; prenatal exposure; prenatal health; prenatal influence; programs; psychiatric symptom; psychological distress; psychological stressor; research study; skills; socioeconomics; success

Despite evidence that 1 in 5 children are at risk for psychiatric disorders, only 1 in 20 young children receive mental health care. Thus, a high number of children who would benefit from mental health care remain untreated. My long-term goal is to improve brain-based targets for early detection and behavioral interventions of childhood psychiatric disorders. The area of perinatal-developmental neuroscience (PDN) is of high public health significance as a substantial proportion of pregnant women will experience health, environmental, or psychological stressors, which have early and long-lasting effects on offspring. Increasing the number of research programs that can support training in PDN is paramount. The K24 will allow me to: 1) expand my expertise in advanced analytic methods to support trainee research, and 2) establish an internationally recognized research and training program focused on fetal-infant brain and behavioral origins of mental health. My K24 training program, the Columbia Engagement, Stability, and Success in PDN will provide an individualized approach to research training: assessing the research skills and career goals of mentees early on and developing personalized training modules; didactics; experiential, hands-on training; and research productivity that follow their individualized plan. The program also includes a monthly seminar series alternating between science and career-networking topics. Our prior studies suggest there may be common biological pathways by which early exposures exert their influence on offspring conferring psychiatric risk – with recent attention to the immune system and/or hypothalamic-pituitary-adrenal axis, and brain regions involved in behavioral regulation. Using the expanded analytic skills obtained through this K24, my mentees and I will conduct studies to examine whether four key prenatal exposures: maternal depression, body mass index, infection, and blood glucose are associated with connectivity and morphology of brain regions (e.g., dorsal anterior cingulate) involved in behavioral regulation. In a subset of the cohort, we will also consider the potential mediating effects of inflammation and glucocorticosteriods. I have a unique opportunity to pool data from cohorts of pregnant women-fetal dyads involved in research studies (2004 to present; n~500) at Columbia University Irving Medical Center – a large center with a diverse patient population – and perform new data collection harnessing health information technology (e.g., electronic medical records). The data set will serve as a platform for my mentees to produce pilot projects and manuscripts, and practical experience conducting a project in an area of PDN that matches his/her career goals within the scope of this funding mechanism. My strong commitment to and ongoing research in patient-oriented research focused on identifying early antecedents of psychiatric risk, individualized mentorship plans, direct involvement of mentees in the conduct of research, and tailored career development program at Columbia University Irving Medical Center are strengths of this application. The K24 mentees will be uniquely positioned to discover neurobiological and behavioral pathways associated with risk.

尽管有证据表明五分之一的儿童面临精神疾病的风险，但只有二十分之一的幼儿接受了 因此，大量原本可以从精神保健中受益的儿童仍未得到治疗。 我的长期目标是改善基于大脑的儿童早期检测和行为干预目标 精神疾病是围产期发育神经科学（PDN）领域的重要公共卫生领域。 相当大比例的孕妇将经历健康、环境或 心理压力，对后代的数量有早期和长期的影响。 能够支持 PDN 培训的研究项目至关重要。K24 将使我能够：1）扩展我的能力。 支持实习生研究的先进分析方法的专业知识，以及 2）建立国际化的 公认的研究和培训计划，重点关注胎儿大脑和心理健康的行为起源。 我的 K24 培训计划、PDN 中的哥伦比亚参与、稳定性和成功将提供个性化的培训 研究培训方法：尽早评估受训者的研究技能和职业目标并发展 个性化培训模块；随后的体验式实践培训； 他们的个性化计划还包括每月一次的科学和科学研讨会系列。 我们之前的研究表明，早期的职业网络可能存在共同的生物学途径。 暴露会对后代产生精神风险的影响——最近人们对免疫的关注 系统和/或下丘脑-垂体-肾上腺轴，以及参与行为调节的大脑区域。 通过本 K24 获得扩展的分析技能，我和我的学员将进行研究以检验是否 四种关键的产前暴露：与母亲抑郁、体重指数、感染和血糖相关 与行为相关的大脑区域（例如背侧前扣带回）的连接性和形态 在该队列的一个子集中，我们还将考虑炎症和炎症的潜在介导作用。 我有一个独特的机会来汇集孕妇-胎儿二元组的数据。 参与哥伦比亚大学欧文医学中心的研究（2004 年至今；n~500）——一个大型研究中心 中心拥有多元化的患者群体 - 并利用健康信息进行新的数据收集 该数据集将作为我的学员制作的平台。 试点项目和手稿，以及在 PDN 领域开展项目的实践经验 他/她的职业目标在此资助机制的范围内。我对和正在进行的研究的坚定承诺。 在以患者为导向的研究中，重点是确定精神风险的早期前因，个性化 指导计划、受指导者直接参与研究以及量身定制的职业发展 哥伦比亚大学欧文医学中心的项目是该应用程序的优势 K24 学员将是。 在发现与风险相关的神经生物学和行为途径方面具有独特的优势。