NRSA Training Core

NRSA 培训核心

• 批准号: 10673704
• 负责人: Marisa N Spann
• 金额: $ 88.49万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-07-01 至 2026-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10673704
• 关键词: Acceleration; American; Association of American Medical Colleges; Back; Basic Science; Clinical Investigator; Clinical and Translational Science Awards; Disease; Education; Effectiveness; Enrollment; Evolution; Funding; Geriatrics; Goals; Health Sciences; Information Dissemination; Internships; Journals; Learning; Master of Science; Medical; Medicine; Methods; Monitor; Names; National Center for Advancing Translational Sciences; National Research Service Awards; Output; Patients; Postdoctoral Fellow; Program Development; Research; Science; Societies; Structure; TNFSF15 gene; Training; Training Programs; Training and Education; Universities; career; career development; clinical practice; curriculum development; design; empowerment; experience; externship; implementation science; improved; innovation; multidisciplinary; next generation; novel; patient oriented research; pre-doctoral; precision medicine; programs; recruit; skills; teacher; translational scientist

Contact PD/PI: Reilly, Muredach P NRSA-Training-001 (819) J. TL1 – TRAINING CORE: PROJECT SUMMARY/ABSTRACT The overarching goal of the Irving Institute's NRSA Training Core is to bring together pre-doctoral and post- doctoral trainees from across the broad spectrum of medicine, the other health sciences, and the basic sciences at Columbia University (CU), and prepare them to be leaders of the next generation of clinical and translational investigators. The Training Core, designated as a TL1 by NCATS, is founded upon a typical NRSA T32 training program, but has unique and innovative features distinguishing it from other T32 programs including the 47 at CU. For example, the TL1 is deeply integrated into our overall Clinical and Translational Science Award (CTSA) Program hub training and education program, TRANSFORM (Training And Nurturing Scholars For Research that is Multidisciplinary), which enables trainees to participate in didactic and experiential programs, including programs focused on team-science, alongside scholars in the KL2 and Master's Degree in Patient Oriented Research programs. The Irving Institute's TL1 also differs from a typical T32 in its disease agnostic approach to recruitment and enrollment of trainees, and the designed focus on Precision Medicine (PM). As such, the program is named TL1-PM. The focus on PM has been stimulated by the CU-wide initiative in PM. Based on experiences during the first funding cycle, as well as the evolution of PM programs at CU, the Specific Aims for the renewal are: Aim 1. To further develop and refine our innovative TL1-PM education and career development program, thereby empowering our scholars and trainees to use the principles of PM to engage in interdisciplinary team science across all translational domains, make new discoveries, and be equipped to implement those discoveries into clinical practice and patient benefit. This TL1 is innovative in its focus on PM, significant coursework and seminars, a structured career development curriculum, and requiring all trainees to take externships. In the next five years, new opportunities will be added, including some focused on team and implementation science. Less successful programs will be scaled back or ended. Aim 2. To demonstrate the effectiveness of existing and new programs through continuous monitoring and assessment for quality improvement, using NCATS Common Metrics as well as our local, customized metrics to evaluate the impact of our educational programs on research output and the career trajectories of our graduates. Aim 3. To accelerate dissemination of the results of novel educational delivery approaches, new methods for assessing trainee learning, and best practices for enhancing interdisciplinary team science skills, to our partners at CU, regional CTSA Hubs (TriCon), and CTSA Program network throughout the nation. Project Summary/Abstract Page 1312 Contact PD/PI: Reilly, Muredach P NRSA-Training-001 (819) J. NSRA TRAINING CORE: REFERENCES 1. &/,& &HQWHU IRU /HDGLQJ ,QQRYDWLRQ &ROODERUDWLRQ ?&RUH FRPSHWHQFLHV IRU FOLQLFDO DQG WUDQVODWLRQDO UHVHDUFK ? >$SULO @ ? KWWSV FOLF- FWVD RUJ VLWHV GHIDXOW ILOHV &76$B&RUHB&RPSHWHQFLHVBILQDOB SGf - $EHGLQ = 5HEHOOR 7- 5LFKDUGV %) 3LQFXV +$ 0HQWRU WUDLQLQJ ZLWKLQ DFDGHPLF KHDOWK FHQWHUV ZLWK &OLQLFDO DQG 7UDQVODWLRQDO 6FLHQFH $ZDUGV Clin Transl Sci. - 30&,' 30& . 7LOOPDQ 5( -DQJ 6 $EHGLQ = 5LFKDUGV %) 6SDHWK-5XEOHH % 3LQFXV +$ 3ROLFLHV DFWLYLWLHV DQG VWUXFWXUHV VXSSRUWLQJ UHVHDUFK PHQWRULQJ D QDWLRQDO VXUYH\ RI DFDGHPLF KHDOWK FHQWHUV ZLWK FOLQLFDO DQG WUDQVODWLRQDO VFLHQFH DZDUGV Academic medicine: journal of the Association of American Medical Colleges. - doi $&0 E H E 30& . $EHGLn?= %LVNXS ( 6LOHt . *DUEXWW -0 .URHQNH . )HOGPDQ 0' 0F*HH 5 -U )OHPLQJ 0 ?3LQFXV+$.'HULYLQJ FRPSHWHQFLHV IRU PHQWRUV RI FOLQLFDO DQG WUDQVODWLRQDO VFKRODUV. Clin Transl Sci. -XQ - . 30&,' 30& . (IVWDWKLRX -$ 'UXPP 05 3DO\ -3 /DZWRQ '0 2 1HLOO 50 1LHPLHUNo $ /HIIHUW /5 /RHIIOHU -6 6KLK +$ Long-WHUP LPSDFW RI D IDFXOW\ PHQWRULQJ SURJUDP LQ DFDGHPLF PHGLFLQH PLoS One. 1RY 1 e doi MRXUQDO SRQH 30&,' 30& . )DUNDV $+ %RQLIDFLQo ( 7XUQHU 5 7LOVWUa 6$ &RUEHOOL -$ 0HQWRUVKLS RI :RPHQ LQ $FDGHPLF 0HGLFLQH a 6\VWHPDWLF 5HYLHZ J Gen Intern Med -XO - doi V - - - 30&,' 30& . 'DUE\VKLUH ' *RUGRQ 0 %DNHU 3 $JLXV 6 0F$OHHU 6 6\VWHPDWLF UHYLHZ RI LQWHUYHQWLRQV WR HQFRXUDJH FDUHHUV LQ DFDGHPLF PHGLFLQH Medical Teacher.? ? - '2, ; 30,' .H\VHU '- $EHGLQ = 6FKXOW] '- 3LQFXV +$ 0HQWRUVKLS LQ WKH FRQWH[W RI LQWHUGLVFLSOLQDU\ JHULDWULF UHVHDUFK OHVVRQV OHDUQHG IURP WKH 5$1' +DUWIRUG 3URJUDP IRU %XLOGLQJ ,QWHUGLVFLSOLQDU\ *HULDWULF 5HVHDUFK &HQWHUV Journal of the American Geriatrics Society. - . 30,' 1 .H\VHU '- /DNRVNL -0 /DUD-&LQLVRPR 6 6FKXOW] '- :LOOLDPV 9/ =HOOHUV ') 3LQFXV +$ $GYDQFLQJ LQVWLWXWLRQDO HIIRUWV WR VXSSRUW UHVHDUFK PHQWRUVKLS D FRQFHSWXDO IUDPHZRUN DQG VHOI-DVVHVVPHQW WRRO $FDGHPLF PHGLFLQH Journal of the Association of American Medical Colleges - 30,' . References Cited Page 1313

联系 PD/PI：Reilly、Muredach P NRSA-Training-001 (819) J. TL1 – 训练核心： 项目概要/摘要 欧文研究所 NRSA 培训核心的总体目标是将博士前和博士后聚集在一起 来自医学、其他健康科学和基础科学领域的博士生 在哥伦比亚大学（CU），培养他们成为下一代临床和转化的领导者 培训核心被 NCATS 指定为 TL1，基于典型的 NRSA T32 培训。 计划，但具有独特和创新的功能，使其区别于其他 T32 计划，包括 47 at 例如，TL​​1 已深度融入我们的整体临床和转化科学奖 (CTSA) 中。 项目中心培训和教育项目 TRANSFORM（培训和培养研究学者） 即多学科），使学员能够参加教学和体验项目，包括 专注于团队科学的项目，以及 KL2 的学者和以患者为中心的硕士学位 欧文研究所的 TL1 与典型的 T32 的不同之处还在于其疾病不可知方法。 培训人员的招募和注册，以及对精准医学 (PM) 的设计重点。 项目被命名为 TL1-PM 对 PM 的关注是由 CU 范围内的 PM 倡议激发的。 第一个资助周期的经验，以及 CU PM 项目的演变，具体目标 更新内容为： 目标 1. 进一步发展和完善我们创新的 TL1-PM 教育和职业发展 计划，从而使我们的学者和学员能够利用 PM 的原则从事跨学科研究 跨所有转化领域的团队科学，做出新发现，并有能力实施这些发现 该 TL1 的创新在于关注 PM，意义重大。 课程和研讨会，结构化的职业发展课程，并要求所有学员参加 未来五年，将会增加新的实习机会，包括一些专注于团队和实习的机会。 实施科学。不太成功的项目将被缩减或终止。 通过持续的质量监控和评估来提高现有和新计划的有效性 改进，使用 NCATS 通用指标以及我们本地的定制指标来评估 我们关于研究成果和毕业生职业轨迹的教育计划 目标 3. 加速。 传播新颖的教育教学方法和评估学员的新方法的成果 为我们在 CU、区域和地区的合作伙伴提供学习和增强跨学科团队科学技能的最佳实践 CTSA 中心 (TriCon) 和遍布全国的 CTSA 计划网络。 项目摘要/摘要页 1312 联系 PD/PI：Reilly、Muredach P NRSA-Training-001 (819) J. NSRA 培训核心：参考资料 1. &/,& &HQWHU IRU /HDGLQJ,QQRYDWLRQ &ROODERUDWLRQ ?&RUH FRPSHWHQFLHV IRU FOLQLFDO DQG WUDQVODWLRQDO UHVHDUFK？>$SULO @？ KWWSV FOLF- FWVD RUJ VLWHV GHIDXOW ILOHV &76$B&RUHB&RPSHWHQFLHVBILQDOB SGf - $EHGLQ = 5HEHOOR 7- 5LFKDUGV %) 3LQFXV +$ 0HQWRU WUDLQLQJ ZLWKLQ DFDGHPLF KHDOWK FHQWHUV ZLWK &OLQLFDO DQG 7UDQVODWLRQDO 6FLHQFH $ZDUGV 临床翻译科学 - 30&，' 30& 。 7LOOPDQ 5( -DQJ 6 $EHGLQ = 5LFKDUGV %) 6SDHWK-5XEOHH % 3LQFXV +$ 3ROLFLHV DFWLYLWLHV DQG VWUXFWXUHV VXSSRUWLQJ UHVHDUFK PHQWRULQJ D QDWLRQDO VXUYH\ RI DFDGHPLF KHDOWK FHQWHUV ZLWK FOLQLFDO DQG WUDQVODWLRQDO VFLHQFH DZDUGV 学术医学：美国医学院协会杂志。 - doi $&0 E H E 30& . $EHGLn?= %LVNXS ( 6LOHt .*DUEXWW -0 .URHQNH .)HOGPDQ 0' 0F*HH 5 -U )OHPLQJ 0 ?3LQFXV+$.'HULYLQJ FRPSHWHQFLHV IRU PHQWRUV RI FOLQLFDO DQG WUDQVODWLRQDO VFKRODUV。 -XQ-.30&,'30&. (IVWDWKLRX -$ 'UXPP 05 3DO\ -3 /DZWRQ '0 2 1HLOO 50 1LHPLHUNo $ /HIIHUW /5 /RHIIOHU -6 6KLK +$ 长 WHUP LPSDFW RI D IDFXOW\ PHQWRULQJ SURJUDP LQ DFDGHPLF PHGLFLQH PLoS 1RY。 1 e doi MRXUQDO SRQH 30&,' 30& 。 )DUNDV $+ %RQLIDFLQo ( 7XUQHU 5 7LOVWUa 6$ &RUEHOOL -$ 0HQWRUVKLS RI :RPHQ LQ $FDGHPLF 0HGLFLQH a 6\VWHPDWLF 5HYLHZ J Gen 实习医生 -XO - doi V - - - 30&,' 30& . '到期\VKLUH' *RUGRQ 0 %DNHU 3 $JLXV 6 0F$OHHU 6 6\VWHPDWLF UHYLHZ RI LQWHUYHQWLRQV WR HQFRXUDJH FDUHHUV LQ DFDGHPLF PHGLFLQH 医学老师。 - '2, ; 30，' .H\VHU '- $EHGLQ = 6FKXOW] '- 3LQFXV +$ 0HQWRUVKLS LQ WKH FRQWH[W RI LQWHUGLVFLSOLQDU\ JHULDWULF UHVHDUFK OHVVRQV OHDUQHG IURP WKH 5$1' +DUWIRUG 3URJUDP IRU %XLOGLQJ，QWHUGLVFLSOLQDU\ *HULDWULF 5HVHDUFK 和 HQWHUV 美国老年医学会杂志 - 30，'1。 .H\VHU '- /DNRVNL -0 /DUD-&LQLVRPR 6 6FKXOW] '- :LOOLDPV 9/ =HOOHUV ') 3LQFXV +$ $GYDQFLQJ LQVWLWXWLRQDO HIIRUWV WR VXSSRUW UHVHDUFK PHQWRUVKLS D FRQFHSWXDO IUDPHZRUN DQG VHOI-DVVHVVPHQW WRRO $FDGHPLF PHGLFLQH 美国医学院协会杂志 - 30，' 。 引用的参考文献第 1313 页

项目成果

Drug development in the era of precision medicine.

精准医学时代的药物开发。

• 发表时间: 2018-03
• 作者: Dugger, Sarah A;Platt, Adam;Goldstein, David B
• 通讯作者: Goldstein, David B

Sporadic hypothalamic hamartoma is a ciliopathy with somatic and bi-allelic contributions.

散发性下丘脑错构瘤是一种具有体细胞和双等位基因贡献的纤毛病。

• 发表时间: 2022-07-21
• 影响因子: 3.5
• 作者: Green, Timothy E;Motelow, Joshua E;Bennett, Mark F;Ye, Zimeng;Bennett, Caitlin A;Griffin, Nicole G;Damiano, John A;Leventer, Richard J;Freeman, Jeremy L;Harvey, A Simon;Lockhart, Paul J;Sadleir, Lynette G;Boys, Amber;Scheffer, Ingrid E;Major
• 通讯作者: Major

Neurodevelopmental deficits and cell-type-specific transcriptomic perturbations in a mouse model of HNRNPU haploinsufficiency.

HNRNPU 单倍体不足的小鼠模型中的神经发育缺陷和细胞类型特异性转录组扰动。

• 发表时间: 2023-10
• 影响因子: 4.5
• 作者: Dugger, Sarah A;Dhindsa, Ryan S;Sampaio, Gabriela De Almeida;Ressler, Andrew K;Rafikian, Elizabeth E;Petri, Sabrina;Letts, Verity A;Teoh, JiaJie;Ye, Junqiang;Colombo, Sophie;Peng, Yueqing;Yang, Mu;Boland, Michael J;Frankel, Wayne N;Goldstein
• 通讯作者: Goldstein

An Integrated Preprocessing Approach for Exploring Single-Cell Gene Expression in Rare Cells.

用于探索稀有细胞中单细胞基因表达的集成预处理方法。

• 发表时间: 2019
• 影响因子: 4.6
• 作者: Shang, Junyi;Welch, David;Buonanno, Manuela;Ponnaiya, Brian;Garty, Guy;Olsen, Timothy;Amundson, Sally A;Lin, Qiao
• 通讯作者: Lin, Qiao

Increased chromosomal mobility after DNA damage is controlled by interactions between the recombination machinery and the checkpoint.

DNA 损伤后染色体迁移率的增加是由重组机制和检查点之间的相互作用控制的。

• 发表时间: 2018-09-01
• 影响因子: 10.5
• 作者: Smith, Michael J;Bryant, Eric E;Rothstein, Rodney
• 通讯作者: Rothstein, Rodney