2/3 Treatment of Anxiety in Autism Spectrum Disorder
2/3 自闭症谱系障碍焦虑的治疗
基本信息
- 批准号:8788047
- 负责人:
- 金额:$ 15.48万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2014
- 资助国家:美国
- 起止时间:2014-01-01 至 2016-12-31
- 项目状态:已结题
- 来源:
- 关键词:Acquired Immunodeficiency SyndromeAddressAdolescentAdverse effectsAffectAftercareAgeAnxietyAnxiety DisordersAutacoidsAutistic DisorderBehavior TherapyBehavioralBinding SitesCharacteristicsChildChildhoodCitiesClinical ServicesClinical TrialsCognitiveCognitive TherapyCommunitiesComorbidityDataData AnalysesDiagnosisDisadvantagedDistressDrug InteractionsEffect Modifiers (Epidemiology)ElementsEvidence based treatmentFelis catusFloridaFrequenciesFriendshipsFundingGoalsHealthImpairmentIndividualInstitutionInterventionLeadershipLinkLiteratureLonelinessMaintenanceMeasuresMediatingMediator of activation proteinMental HealthMental disordersMonitorOutcomeParentsPatientsPharmaceutical PreparationsPoly(ADP-ribose) PolymerasesPopulationProceduresProtocols documentationPublic HealthPublicationsRandomizedRandomized Clinical TrialsRandomized Controlled TrialsRecruitment ActivityRecurrenceRelapseRelative (related person)ResearchResearch PersonnelResourcesSchoolsServicesSeveritiesSiteSocial FunctioningSpecific qualifier valueStructureSymptomsSyndromeTestingTrainingTreatment EfficacyTreatment ProtocolsTreatment outcomeUnited States National Institutes of HealthUniversitiesWood materialWorkYouthalcohol use disorderanxiety treatmentautism spectrum disorderbasebehavior observationclinically significantcopingdata managementdesignexperienceflexibilityfollow-upfunctional outcomesimprovedmeetingspersonalized interventionprogramspsychosocialquality assuranceresponsesocialsocial anxietysymposiumtreatment adherencetreatment effecttreatment of anxiety disorderstreatment responsetreatment sitetrial comparing
项目摘要
DESCRIPTION (provided by applicant): Autism spectrum disorders (ASD) are common neurodevelopmental syndromes affecting 1% of U.S. children. Comorbid anxiety disorders affect 40 to 50% of children with ASD, causing substantial distress and impairment over and above that caused by ASD alone. High anxiety is associated with increased severity of ASD symptoms and social maladjustment in affected youth. Further, parents of children with ASD consider anxiety- related problems to be among the top two challenges facing their children. [Although standard practice cognitive-behavioral therapy (CBT) has been established as an efficacious and safe treatment for anxiety disorders among typically developing youth, its utility in comorbid cases with ASD remains unknown. To date, no studies have experimentally compared standard practice CBT to a cognitive-behavioral intervention that has been personalized for children with a comorbid presentation of anxiety and ASD.] This gap in the literature is of particular concern because there are no empirically-supported treatment options for youth with ASD and comorbid anxiety, and existing pharmacological interventions may have some disadvantages (e.g., limited efficacy in this population, side effects, and potential for drug
x drug interactions). [Accordingly, we are proposing a randomized controlled trial to be conducted at three treatment sites to evaluate the efficacy of personalized CBT for anxiety in ASD (Behavioral Intervention for Anxiety in Children with Autism: BIACA) relative to standard practice CBT for anxiety (Coping Cat program). Over the last five years, the proposed BIACA intervention has been adapted and tailored to the characteristics and needs of high-functioning children with ASD; the Coping Cat program reflects the community standard that has been empirically supported in multiple NIH-funded trials.] In response to the NIH Roadmap Initiative, BIACA employs a modular treatment approach, allowing the intervention to be personalized to each youngster's unique needs. [Thus, the proposed research will: (1) examine the efficacy of BIACA relative to Coping Cat, which represents standard practice treatment, (2) evaluate the maintenance of treatment gains, (3) examine the impact of personalized intervention on functional outcomes such as social responsiveness, loneliness, and friendship quality, (4) test autism severity as a moderator of treatment outcome, and (5) explore other moderators and mediators of treatment outcome.] A total of 180 youth (ages 8-13 years) with ASD and co-occurring anxiety will be randomly assigned to one of the two treatment conditions. The three recruitment sites for this study are UCLA, the University of South Florida (USF), and Temple University. USF will provide data management services. Considering the rising number of children diagnosed with ASD together with the frequency and severity of comorbid anxiety, the proposed work is tailored to the unique needs of youth with ASD and will provide a timely contribution to public health efforts.
描述(由申请人提供):自闭症谱系障碍(ASD)是影响1%美国儿童的常见神经发育综合征。合并症焦虑症会影响40%至50%的ASD儿童,从而造成仅由ASD造成的严重困扰和障碍。高焦虑与受影响青年的ASD症状严重程度增加和社会失调有关。此外,患有ASD的儿童的父母认为与焦虑有关的问题是孩子面临的前两个挑战之一。 [尽管已经确定了标准实践认知疗法(CBT)是一种有效且安全的治疗,以治疗通常发展的年轻人的焦虑症,但其在与ASD合并症病例中的效用尚不清楚。 To date, no studies have experimentally compared standard practice CBT to a cognitive-behavioral intervention that has been personalized for children with a comorbid presentation of anxiety and ASD.] This gap in the literature is of particular concern because there are no empirically-supported treatment options for youth with ASD and comorbid anxiety, and existing pharmacological interventions may have some disadvantages (e.g., limited efficacy in this population, side效果和药物的潜力
X药物相互作用)。 [因此,我们提出了一项随机对照试验,将在三个治疗部位进行,以评估个性化CBT对ASD焦虑的疗效(自闭症儿童焦虑的行为干预:BIACA的焦虑:BIACA)相对于焦虑的标准实践CBT(应对CAT计划)。在过去的五年中,拟议的BIACA干预已根据ASD的高功能儿童的特征和需求进行了调整和量身定制。应对CAT计划反映了在多个NIH资助的试验中得到经验支持的社区标准。 [因此,拟议的研究将:(1)检查BIACA相对于应对CAT的疗效,该猫代表标准实践治疗,(2)评估治疗收益的维持,((3)检查个性化干预对社会响应性,孤独感和友谊质量等功能性结果的影响,(4)测试自动疗法的治疗方法,并将其用于治疗的过程,并探讨了其他调查结果(5),(5)提出了一个调查范围(5)。在180名ASD和同时发生焦虑的年轻人(8-13岁)中,将随机分配给两个治疗条件之一。这项研究的三个招聘站点是UCLA,南佛罗里达大学(USF)和Temple University。 USF将提供数据管理服务。考虑到被诊断出患有ASD的儿童的数量增加,以及合并症的频率和严重性,拟议的工作是根据ASD的青年人的独特需求量身定制的,并将为公共卫生的努力提供及时的贡献。
项目成果
期刊论文数量(0)
专著数量(0)
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会议论文数量(0)
专利数量(0)
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