ONTOGENY OF THE CIRCADIAN BODY TEMPERATURE RHYTHM

昼夜体温节律的个体发生

• 批准号: 3413126
• 负责人: E M KITTRELL
• 金额: $ 5.26万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-07-01 至 1990-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3413126
• 关键词: body temperature; body temperature regulation; brain regulatory center; circadian rhythms; experimental brain lesion; gestational age; growth /development; histology; hypothalamus; immature animal; laboratory rat; lactation; neurophysiology; newborn animals; prenatal stress; prolactin; psychomotor function; stereotaxic techniques; water drinking behavior

There is a highly specific temporal ordering of rhythmic patterns in physiological systems. Sleep-wake cycles, growth-hormone secretion, potassium secretion, and cortisol levels all fluctuate in a precise relationship with the circadian temperature rhythm (CTR). The timing of these physiological processes is quite similar across numerous species. There is a growing body of evidence that loss of temporal organization among various biological rhythm systems is a concomitant of some forms of mental illness such as depression, and manic depressive illness. The mechanisms that link rhythm abberations to mood disorders are unknown, but the data currently being gathered suggest that the association of the two is more than casual. The CTR is one of the rhythm systems that appears disturbed in mood disorders. We have been engaged in studying the ontogeny of the CTR in rats and have reported that the CTR emerges around 25 days of age and continues to develop until 35-40 days. We plan to continue this work by examining behavioral, physiological, and neurophysiological mechanisms that may underlie rhythm ontogeny in the rat with a particular emphasis on the development and subsequent maintenance of the CTR. We measure temperature, drinking, and activity via telemetry signals every 5 min from 10 days of age. Studies on the ontogeny of various rhythms in rodents suggest that both prenatal and postnatal factors affect the development of normal rhythmicity. Our knowledge of rhythm dysfunction effects upon mental health disorders can be enhanced by a better understanding of the ontogenetical processes that produce temporal organization in biological organisms. Light shed on CTR development may reflect on rhythm ontogeny in general and illuminate maturational processes and environmental influences critical to normal functioning.

有节奏模式有高度特定的时间顺序 在生理系统中。 睡眠唤醒周期，生长激素 分泌，钾的分泌和皮质醇水平都波动 与昼夜节律节奏的精确关系 （CTR）。 这些生理过程的时机非常 众多物种相似。 越来越多的身体 证据表明，各种暂时性组织的丧失 生物节奏系统是某些形式的伴随 抑郁症和躁狂抑郁症等精神疾病。 将节奏差与情绪障碍联系起来的机制 是未知的，但是目前正在收集的数据表明 两者的关联不仅仅是休闲。 CTR是之一 似乎在情绪障碍中干扰的节奏系统。 我们一直从事研究大鼠CTR的个体发育 并报道CTR出现在25天大约25天大的时候 并继续发展到35-40天。 我们计划继续 这项工作通过检查行为，生理和 神经生理机制可能是节奏的基础 大鼠的个体发育，特别强调发展 并随后维护CTR。 我们衡量 每5个通过遥测信号的温度，饮酒和活动 最小10天的年龄。 关于各种本体发育的研究 啮齿动物的节奏表明产前和产后 因素会影响正常节奏的发展。 我们的 了解节奏功能障碍对心理健康的影响 可以通过更好地理解 建立暂时性组织的地理过程 生物生物。 CTR开发的轻棚可能 反思节奏的本体发育，并照亮成熟 过程和环境对正常关键的影响 功能。