ONTOGENY OF THE CIRCADIAN BODY TEMPERATURE RHYTHM

昼夜体温节律的个体发生

• 批准号: 3449759
• 负责人: E M KITTRELL
• 金额: $ 4.58万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 1984
• 资助国家: 美国
• 起止时间: 1984-02-01 至 1986-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3449759
• 关键词: aging; body temperature regulation; circadian rhythms; eating; experimental brain lesion; growth /development; infant animal; lighting; mature animal; mother child interaction; neurophysiology; telemetry; temperature

The adult rat (Rattus norvegicus) has a prominent 24-hr variation in body temperative (Tb). Althrough subject to external influences, the circadinan temperature rhythm is endogenously generated and persists when environmental cues are held constant. The hypothalamus appears to be critically involved in the CTR system, but the underlying neural circuitry remains to be worked out. Very little is known regarding developmental influences on the emergence and expression of the CTR in rats. I am proposing a program of research to examine maternal, environmental, and neural contributions to the development of the CTR in rats. Continuous 10-min-interval measurements of telemetered Tb from 8 or 10 Days of age to adulthood will be used to determine period, phase, and amplitude changes in the CTR over this time period. The combupterized data collection system is currently in operation in our lab. I plan experiments which will help answer such questions as: 1) Does the dam impose a CTR on her pups that is reflected in the development of their CTR? 2) how does the CTR develop from Day 1 in pups deprived of maternal influences? 3) Do light, temperature, and feeding cycles affect CTR emergence? 4) what role do various hypothalamic areas play in CTR ontogeny? 5) Are there circadian variations in temperature regulation during development? Information regarding these issues and others is presently unavailable. It is known, however, that loss of temporal organization among biological systems characterizes the aging process in humans and animals. It has also been suggested that a serious thermoregulatory deficit observed in elderly persons, accidental hypothermia, may be a result of circadian desynchronization of thermoregulatory mechanisms in the face of thermal challenge. Our knowledge of rhythm dissociations and aging will be enhanced by a clearer understanding of the ontogenetical processes that contribute to temporal organization in developing organisms. The CTR is intimately linked with rhythmical patterns observed in other physiological systems. Light shed on CTR development will reflect on rhythm emergence in rodents in general and may illuminate maturetional processes and environmental influences critical to normal functioning.

成年大鼠（Rattus norvegicus）的身体有显着的24小时变化 温度（TB）。 受外部影响的影响，洋洲 温度节奏是内源产生的，当 环境线索保持不变。 下丘脑似乎是 CTR系统批判性涉及，但基础神经回路 还有待解决。 关于发展知之甚少 对CTR在大鼠中的出现和表达的影响。 我是 提出一项研究计划，以检查产妇，环境和 对大鼠CTR发展的神经贡献。 连续的 从8岁或10天的遥测结核对10分钟的间隙测量到 成年将用于确定周期，相位和振幅变化 该时间段的CTR。 组合数据收集系统是 目前在我们的实验室中运营。 我计划实验，这将有所帮助 回答以下问题：1）大坝对她的幼犬强加了一个CTR 反映在其CTR的开发中？ 2）CTR如何发展 从第1天开始，幼犬被剥夺了产妇影响？ 3）亮， 温度和进食周期会影响CTR出现吗？ 4）扮演什么角色 CTR发育中的各种下丘脑区域发挥作用？ 5）是否有昼夜演出 发育过程中温度调节的变化？ 信息 关于这些问题和其他问题目前不可用。 我们都知道， 但是，生物系统之间的时间组织丧失 表征人类和动物的衰老过程。 也一直 提出在老年人中观察到的严重的温度调节缺陷 意外体温过低的人可能是昼夜节律的结果 面对热调节机制的干燥调节机制 挑战。 我们对节奏分离和衰老的了解将是 通过更清楚地理解对个体遗传学过程的增强 为发展生物的临时组织做出贡献。 CTR是 与在其他生理学中观察到的有节奏模式密切相关 系统。 CTR开发的轻棚将反映出节奏的出现 啮齿动物一般，可能会阐明成熟过程和 环境对正常功能至关重要。