A Biobehavioral Approach to Understand Problematic Avoidant/Restrictive Eating in Adults with Functional Dyspepsia

一种了解功能性消化不良成人问题性回避/限制性饮食的生物行为方法

• 批准号: 10351067
• 负责人: Helen Burton Murray
• 金额: $ 19.95万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-13 至 2026-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10351067
• 关键词: Address; Adult; Advisory Committees; Affect; Aftercare; Appetite Regulation; Applications Grants; Area; Behavior Therapy; Behavioral; Biological; Biological Markers; Biological Response Modifier Therapy; Body Image; Body Weight decreased; Burning Pain; Cholecystokinin; Chronic; Clinical; Clinical Investigator; Clinical Trials; Cognitive Therapy; Complement; Data; Development; Diet; Dyspepsia; Eating; Endocrine; Enrollment; Enteral Feeding; Epigastric; Evaluation; Exposure to; Food; Future; Gastroenterology; Gastroparesis; Goals; Health Care Costs; Hormones; Impairment; Individual; Intervention; K-Series Research Career Programs; Learning; Malnutrition; Medical; Mentors; Mentorship; Morbidity - disease rate; Motor; National Institute of Diabetes and Digestive and Kidney Diseases; Nausea; Nutritional status; Outcome; Patients; Peptide YY; Phase; Preparation; Protocols documentation; Psychologist; Psychology; Quality of life; Randomized; Randomized Controlled Trials; Research; Research Personnel; Research Priority; Role; Satiation; Scientist; Sensorimotor functions; Severities; Stomach; Symptoms; Testing; Training; United States National Institutes of Health; avoidant restrictive food intake disorder; base; behavioral clinical trial; behavioral study; biobehavior; biopsychosocial; career development; cohort; comparative efficacy; dietary approach; early satiety; experience; food avoidance; gastrointestinal; improved; improved outcome; innovation; interdisciplinary approach; meetings; motility disorder; multidisciplinary; patient oriented research; programs; restrictive eating; satisfaction; skills; social; symptom management; translational scientist; treatment as usual; treatment research

PROJECT SUMMARY/ABSTRACT Functional dyspepsia (FD) is a chronic gastrointestinal functional/motility disorder that affects up to 12% of US adults with significant morbidity and healthcare costs and has limited treatment options. Detrimental eating- related medical consequences are frequent in FD, with a level of food avoidance/restriction meeting criteria for avoidant/restrictive food intake disorder (ARFID) in up to 40% of adults with FD. However, the biological mechanisms of problematic avoidant/restrictive eating in FD have been underexplored and could inform behavioral and biological intervention targets. This 5-year K23-Patient-Oriented Research Career Development award addresses this research gap by using an innovative, multi-disciplinary approach to examine: (1) differences in gastric sensorimotor functions and satiety hormones among adults with FD and ARFID, FD without ARFID, and healthy controls; and (2) pilot feasibility, preliminary efficacy, and preliminary mechanisms of an exposure-based cognitive-behavioral treatment in patients with FD and ARFID. This project represents the first exploration of the mechanistic role of problematic avoidant/restrictive eating in FD and the potential benefit of an intervention that exposes patients with FD to increased food volume/variety. The training plan corresponding to this project will support Dr. Helen Burton Murray in becoming an independent clinical scientist with a program of research examining biopsychosocial target mechanisms of gastrointestinal functional/motility disorders to inform behavioral and biological treatment interventions. The study aims complement Dr. Burton Murray’s objectives for her advancement as an independent clinical and translational investigator, achieved through four training areas: gastric sensorimotor functions, endocrine regulation of appetite, behavioral clinical trials evaluation and treatment mechanisms, and career development. Training goals will be implemented under the guidance of Dr. Braden Kuo (primary mentor); Drs. Elizabeth A. Lawson and Jennifer J. Thomas (co- mentors); Drs. Brjánn Ljótsson and Brian Healy (consultants); and Drs. Lukas Van Oudenhove, Johnathan Williams, and Laurie Keefer (scientific advisory committee).

项目概要/摘要 功能性消化不良 (FD) 是一种慢性胃肠道功能/运动障碍，影响高达 12% 的美国人 发病率高、医疗费用高且治疗选择有限的成年人。 相关的医疗后果在 FD 中很常见，避免/限制食物的程度符合以下标准： 高达 40% 的 FD 成年人患有回避/限制性食物摄入障碍 (ARFID)。 FD 中存在问题的回避/限制性饮食的机制尚未得到充分探索，可以为 FD 患者提供指导 这个为期 5 年的 K23 以患者为导向的研究职业发展目标。 该奖项通过使用创新的多学科方法来研究以下方面，从而弥补了这一研究空白：(1) FD 和 ARFID、FD 成人胃感觉运动功能和饱腹感激素的差异 没有ARFID，并且有良好的控制；(2) 试点可行性、初步效果和初步机制； 该项目代表了针对 FD 和 ARFID 患者的基于暴露的认知行为治疗。 首次探索有问题的回避/限制性饮食在 FD 中的机制作用及其潜力 增加 FD 患者食物量/种类的干预措施的益处 培训计划。 对应该项目将支持Helen Burton Murray博士成为一名独立的临床科学家 开展一项研究胃肠道功能/运动的生物心理社会目标机制的研究计划 该研究旨在补充伯顿博士的观点，为行为和生物治疗干预提供信息。 默里（Murray）作为独立临床和转化研究者的晋升目标已经实现 通过四个训练领域：胃感觉运动功能、食欲内分泌调节、行为临床 试验评估和治疗机制以及职业发展目标将得到落实。 在 Braden Kuo 博士（主要导师）和 Jennifer J. Thomas 博士（共同导师）的指导下； Brjánn Ljótsson 博士和 Brian Healy 博士（顾问）；Lukas Van Oudenhove 博士、Johnathan 威廉姆斯和劳里·基弗（科学顾问委员会）。