A Biobehavioral Approach to Understand Problematic Avoidant/Restrictive Eating in Adults with Functional Dyspepsia

一种了解功能性消化不良成人问题性回避/限制性饮食的生物行为方法

基本信息

批准号：
10841228
负责人：
Helen Burton Murray
金额：
$ 7.56万
依托单位：
MASSACHUSETTS GENERAL HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-09-13 至 2026-09-28
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10841228
关键词：
Address Administrative Supplement Adult Advisory Committees Affect Aftercare Appetite Regulation Area Award Behavior Therapy Behavioral Biological Biological Markers Biological Response Modifier Therapy Body Image Body Weight decreased Cholecystokinin Chronic Clinical Clinical Investigator Clinical Trials Cognitive Therapy Complement Data Data Collection Development Diet Dyspepsia Eating Eligibility Determination Endocrine Enrollment Enteral Feeding Epigastric Essential worker Evaluation Exposure to Food Future Gastroparesis Goals Health Care Costs Hormones Impairment Individual Intervention Investigation K-Series Research Career Programs Learning Malnutrition Medical Mentors Mentorship Morbidity - disease rate Motor Nausea Nutritional status Outcome Pain Parents Patients Peptide YY Phase Protocols documentation Psychologist Quality of life Randomized Randomized, Controlled Trials Research Role Satiation Scientist Sensorimotor functions Severities Stomach Symptoms Training avoidant restrictive food intake disorder behavioral clinical trial biobehavior biopsychosocial career development cohort dietary approach early satiety experience feasibility testing food avoidance gastrointestinal improved improved outcome innovation interdisciplinary approach meetings motility disorder patient oriented research pilot test preservation programs restrictive eating satisfaction skills social success symptom management timeline translational scientist treatment as usual treatment research

项目摘要

PROJECT SUMMARY/ABSTRACT Functional dyspepsia (FD) is a chronic gastrointestinal functional/motility disorder that affects up to 12% of US adults with significant morbidity and healthcare costs and has limited treatment options. Detrimental eating- related medical consequences are frequent in FD, with a level of food avoidance/restriction meeting criteria for avoidant/restrictive food intake disorder (ARFID) in up to 40% of adults with FD. However, the biological mechanisms of problematic avoidant/restrictive eating in FD have been underexplored and could inform behavioral and biological intervention targets. This 5-year K23-Patient-Oriented Research Career Development award addresses this research gap by using an innovative, multi-disciplinary approach to examine: (1) differences in gastric sensorimotor functions and satiety hormones among adults with FD and ARFID, FD without ARFID, and healthy controls; and (2) pilot feasibility, preliminary clinical outcomes, and preliminary mechanisms of an exposure-based cognitive-behavioral treatment in patients with FD and ARFID. This project represents the first exploration of the mechanistic role of problematic avoidant/restrictive eating in FD and the potential benefit of an intervention that exposes patients with FD to increased food volume/variety. The training plan corresponding to this project will support Dr. Helen Burton Murray in becoming an independent clinical scientist with a program of research examining biopsychosocial target mechanisms of gastrointestinal functional/motility disorders to inform behavioral and biological treatment interventions. The study aims complement Dr. Burton Murray’s objectives for her advancement as an independent clinical and translational investigator, achieved through four training areas: gastric sensorimotor functions, endocrine regulation of appetite, behavioral clinical trials evaluation and treatment mechanisms, and career development. Training goals will be implemented under the guidance of Dr. Braden Kuo (primary mentor); Drs. Elizabeth A. Lawson and Jennifer J. Thomas (co-mentors); Drs. Brjánn Ljótsson and Brian Healy (consultants); and Drs. Lukas Van Oudenhove, Johnathan Williams, and Laurie Keefer (scientific advisory committee). The purpose of this proposed supplement award is to provide Dr. Burton Murray with essential staff support during the most active data collection year planned. Supplement support will preserve the success of Dr. Burton Murray in achieving the above aims and facilitate her successful K-to-R transition.

项目概要/摘要功能性消化不良 (FD) 是一种慢性胃肠道功能/运动障碍，影响高达 12% 的美国人发病率高、医疗费用高且治疗选择有限的成年人。相关的医疗后果在 FD 中很常见，避免/限制食物的程度符合以下标准：高达 40% 的 FD 成年人患有回避/限制性食物摄入障碍 (ARFID)。 FD 中存在问题的回避/限制性饮食的机制尚未得到充分探索，可以为 FD 患者提供指导这个为期 5 年的 K23 以患者为导向的研究职业发展目标。该奖项通过使用创新的多学科方法来研究以下方面，从而弥补了这一研究空白：(1) FD 和 ARFID、FD 成人胃感觉运动功能和饱腹感激素的差异没有 ARFID 和健康控制；以及 (2) 试点可行性、初步临床结果和初步结果 FD 和 ARFID 患者基于暴露的认知行为治疗机制。代表了对有问题的回避/限制性饮食在 FD 和增加 FD 患者食物量/种类的干预措施的潜在益处与该项目相对应的计划将支持 Helen Burton Murray 博士成为一名独立的临床医生科学家进行了一项研究计划，检查胃肠道的生物心理社会目标机制该研究旨在为行为和生物治疗干预提供信息。 Burton Murray 博士作为独立临床和转化补充者的发展目标研究者，通过四个训练领域实现：胃感觉运动功能、内分泌调节食欲、行为临床试验评估和治疗机制以及职业发展。目标将在 Braden Kuo 博士（主要导师）的指导下实施； Jennifer J. Thomas（共同导师）；以及 Drs. Brjánn Ljótsson 和 Brian Healy（顾问）； Oudenhove、Johnathan Williams 和 Laurie Keefer（科学顾问委员会）。拟议的补充奖励旨在为 Burton Murray 博士提供必要的工作人员支持计划中最活跃的数据收集年将保持伯顿博士的成功。 Murray 实现了上述目标，并促进了她从 K 到 R 的成功转型。

项目成果

期刊论文数量（7）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Does Gluten Avoidance in Patients with Celiac Disease Increase the Risk of Developing Eating Disorders?

乳糜泻患者避免麸质是否会增加饮食失调的风险？

DOI：
发表时间：
2023-07
期刊：
影响因子：
3.1
作者：
Abber, Sophie R;Burton Murray, Helen
通讯作者：
Burton Murray, Helen

Analysis of Age, Race, Ethnicity, and Sex of Participants in Clinical Trials Focused on Disorders of Gut-Brain Interaction.

对肠脑相互作用障碍临床试验参与者的年龄、种族、民族和性别进行分析。

DOI：
发表时间：
2022-09
期刊：
影响因子：
29.4
作者：
Bar, Nir;Surjanhata, Brian;Weeks, Imani;Mgh Center For Neurointestinal Health;Silver, Julie K;Burton Murray, Helen
通讯作者：
Burton Murray, Helen

Validation of the youth-nine item avoidant/restrictive food intake disorder screen.

青少年九项回避/限制性食物摄入障碍筛查的验证。

DOI：
发表时间：
2024-01
期刊：
影响因子：
0
作者：
Billman Miller, Marley G;Zickgraf, Hana F;Murray, Helen Burton;Essayli, Jamal H;Lane
通讯作者：
Lane

Identification and Management of Eating Disorders (including ARFID) in GI Patients.

胃肠道患者饮食失调（包括 ARFID）的识别和管理。

DOI：
发表时间：
2022-12
期刊：
影响因子：
3.7
作者：
Burton Murray, Helen;Calabrese, Samantha
通讯作者：
Calabrese, Samantha

Assessing the presence and motivations of orthorexia nervosa among athletes and adults with eating disorders: a cross-sectional study.

评估患有饮食失调的运动员和成人中神经性厌食症的存在和动机：一项横断面研究。

DOI：
发表时间：
2023-12-09
期刊：
影响因子：
0
作者：
Foyster, Mandy;Sultan, Nessmah;Tonkovic, Matilda;Govus, Andrew;Burton;Tuck, Caroline J;Biesiekierski, Jessica R
通讯作者：
Biesiekierski, Jessica R