Analytical capacity building for the study of tobacco carcinogen exposures in India

印度烟草致癌物暴露研究的分析能力建设

• 批准号: 9371941
• 负责人: Pankaj Chaturvedi
• 金额: $ 28.6万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-08-22 至 2022-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9371941
• 关键词: Address; Advocacy; Alcohol consumption; Area; Aromatic Polycyclic Hydrocarbons; Biochemical; Biological Markers; Butanones; Cancer Etiology; Carcinogen exposure; Carcinogens; Case-Control Studies; Cessation of life; Characteristics; Chemicals; Clinical; Clinical Research; Collaborations; Communities; Cotinine; Custom; Data; Development; Education; Ensure; Epidemiology; Etiology; Formulation; Goals; Head and Neck Cancer; Health; Hospitals; India; Institutes; Institution; Knowledge; Laboratories; Limes; Link; Malignant Neoplasms; Malignant neoplasm of esophagus; Malignant neoplasm of pancreas; Measures; Morbidity - disease rate; N' -nitrosonornicotine; Nicotine; Nitrates; Nitrites; Nitrosamines; Oral; Participant; Perception; Play; Population; Positioning Attribute; Preparation; Procedures; Public Health; Research; Research Personnel; Research Training; Resources; Role; Scientist; Smokeless Tobacco; Tobacco; Tobacco use; Tobacco-Associated Carcinogen; Training; Training Activity; Variant; Vision; Work; World Health Organization; base; cancer risk; carcinogenicity; data resource; head and neck cancer patient; insight; malignant mouth neoplasm; mortality; multidisciplinary; novel; programs; public health research; repository; smoking prevalence; snuff; snus; tobacco carcinogenesis; uptake; urinary; web portal; webinar

ABSTRACT Cancer risks associated with the use of smokeless tobacco (SLT) products worldwide vary drastically. There is a critical need to better understand SLT carcinogenesis, and which chemical constituents and/or product characteristics drive the risk of cancer development in SLT users. India has a unique tobacco burden profile and represents both an area of critical need and unique setting for such studies. Nearly one third of the population in India is using various forms of SLT, exceeding the prevalence of smoking. This is accompanied by high rates of oral and head and neck cancer (OHNC), which is strongly associated with SLT use and is a leading cause of cancer-related death in India. The goal of our proposal is to investigate the relationship between carcinogen content in SLT products and relevant exposures as well as OHNC risk in users of these products, while concurrently building capacity for a sustainable tobacco carcinogenesis research program in India. We will focus on the tobacco-specific nitrosamines N'-nitrosonornicotine (NNN) and 4- (methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). Our first aim will be to determine the variation of NNN and NNK in SLT products currently available in Mumbai including a wide range of both manufactured and cottage-made products. Our second aim will be to examine the relationship between NNN and NNK levels in SLT products and the levels of corresponding biomarkers in users of these products. In this aim, we will assess biomarkers of exposure in 300 users of SLT products with differing NNN and NNK content, as established in Aim 1. In our third aim, we will compare levels of urinary NNN and NNK biomarkers between SLT users with and without OHNC. Together, these studies we will generate important insights into the role of NNN and NNK in SLT carcinogenesis in India. While substantial work has been carried out by the Indian public health research and advocacy community to generate valuable knowledge on SLT use, perceptions, and epidemiology, biomarker-based studies of tobacco carcinogen exposure and cancer risk have never been conducted in India. Our research team is uniquely positioned to initiate this research, as it will leverage our collaborative partnership with clinicians and scientists at Tata Memorial Hospital and its affiliated Advanced Center for Training, Research and Education in Cancer in Mumbai. In addition to generating novel scientific data, this study will incorporate capacity building activities that are closely linked to the Specific Aims and include the development of analytical laboratory capacity, training of young investigators from Mumbai in tobacco research procedures, and establishment of tobacco product and biospecimen repositories for future research.

抽象的 全球范围内与使用无烟烟草 (SLT) 产品相关的癌症风险差异很大。有 迫切需要更好地了解 SLT 致癌作用以及哪些化学成分和/或产品 特征会增加 SLT 使用者罹患癌症的风险。印度具有独特的烟草负担状况 并且代表了此类研究的迫切需求领域和独特环境。近三分之一的 印度人口正在使用各种形式的无烟烟草，超过了吸烟的流行率。这是伴随着 口腔癌和头颈癌 (OHNC) 的高发病率与 SLT 的使用密切相关，是一种 印度癌症相关死亡的主要原因。我们提案的目标是调查这种关系 SLT 产品中的致癌物含量与相关暴露以及这些产品使用者的 OHNC 风险之间的关系 产品，同时建设可持续烟草致癌研究计划的能力 印度。我们将重点关注烟草特有的亚硝胺 N'-亚硝基降烟碱 (NNN) 和 4- (甲基亚硝基氨基)-1-(3-吡啶基)-1-丁酮(NNK)。我们的首要目标是确定 NNN 的变化 和 NNK 的 SLT 产品目前在孟买销售，包括各种制造和销售产品 山寨产品。我们的第二个目标是检查 NNN 和 NNK 水平之间的关系 SLT 产品以及这些产品用户中相应生物标志物的水平。为了这个目标，我们将评估 300 名 SLT 产品使用者的暴露生物标志物具有不同的 NNN 和 NNK 含量，如 目标 1. 在我们的第三个目标中，我们将比较 SLT 使用者与 并且没有 OHNC。通过这些研究，我们将对 NNN 和 NNK 的作用产生重要的见解 印度的 SLT 致癌研究。尽管印度公共卫生部门已经开展了大量工作 研究和倡导社区生成有关 SLT 使用、看法和认识的宝贵知识 流行病学、基于生物标志物的烟草致癌物暴露和癌症风险研究从未被 在印度进行。我们的研究团队处于独特的地位来启动这项研究，因为它将利用我们的 与塔塔纪念医院及其附属先进医院的临床医生和科学家建立合作伙伴关系 孟买癌症培训、研究和教育中心。除了产生新颖的科学 数据，本研究将纳入与具体目标和密切相关的能力建设活动 包括发展分析实验室能力、对来自孟买的年轻研究人员进行培训 烟草研究程序，以及为未来建立烟草产品和生物样本库 研究。