BIOLOGICALLY ACTIVE SMALL CAGE BORON COMPOUNDS

具有生物活性的小笼硼化合物

• 批准号: 5211617
• 负责人: THOMAS P ONAK
• 金额: --
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/5211617
• 关键词: antileukemic agent; boranes; chemical structure function; drug design /synthesis /production; drug screening /evaluation; gas chromatography mass spectrometry; infrared spectrometry; nuclear magnetic resonance spectroscopy

The proposed work is based on the hypothesis that synthetic routes to biologically active derivatives of polyboron hydride moieties, designed to be useful in chemotherapy, can be appropriately identified; and that the stated synthetic, and structural assignment, goals can be accomplished by the postulated methods given herein. Principal efforts will be devoted to the syntheses of carboranes containing a nitrogen attachment analogous to those that have already shown confirmed activity. Various functionalities will be introduced onto promising molecules in attempts to affect the lipid, and aqueous, solubilities of these systems, and also to provide useful precursors to the nitrogen derivatives of the polyboranes. Proposed routes to these functionalized boron systems, and related compounds, will be explored. Nuclear Magnetic Resonance calculational methods (IGLO and GIAO) will be employed to make structural assignments and to examine possible conformers in space of various boron analogues of amino acids as well as amine complexes of polyboranes. The anticancer activity and other medicinal applications will be correlated to structural relationships of a variety of (poly)boron compounds and their derivatives. Both of the two undergraduates and the graduate student, as well as the principal investigator, will carry out laboratory research projects to achieve these goals.

拟议的工作是基于以下假设 Polyboron Hydride部分的生物活性衍生物，设计为 在化学疗法中有用，可以适当地鉴定出来；那是 陈述的合成和结构分配，目标可以通过 本文给出的假定方法。主要努力将致力于 含有氮的附着的卡堡的合成，类似于 那些已经显示出确认的活动的人。各种功能 将引入有希望的分子以尝试影响 这些系统的脂质和水溶性，也提供 对聚硼烷的氮衍生物的有用前体。建议的 这些功能化的硼系统和相关化合物的路线将 被探索。核磁共振计算方法（IGLO和 GIAO）将被用来进行结构分配并检查 氨基酸的各种硼类似物的空间中可能的构象异构体为 以及聚硼烷的胺复合物。抗癌活性和其他 药用应用将与 各种（多）硼化合物及其衍生物。两个 本科生和研究生以及校长 研究人员将进行实验室研究项目以实现这些目标 目标。