BIOLOGICALLY ACTIVE SMALL CAGE BORON COMPOUNDS

具有生物活性的小笼硼化合物

• 批准号: 3915687
• 负责人: THOMAS P ONAK
• 金额: --
• 依托单位: CALIFORNIA STATE UNIVERSITY LOS ANGELES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3915687
• 关键词: antileukemic agent; boranes; boron; chemical structure function; chemical synthesis; drug screening /evaluation; organometallic compounds

Biologically active derivatives of small cage boron hydride moieties, to be used in chemotherapy, will be synthesized. The emphasis will be on the synthesis of polyboranes containing a nitrogen attachment similar to those that have already shown confirmed activity against the leukemia P-388 test system. Functionalities will be introduced onto promising molecules in attempts to change the lipid solubilities of these systems. Structural relationships of boron compounds will be correlated to anticancer activity and other medicinal applications. Both of the two undergraduates and the graduate student, as well as the principal investigator, will carry out laboratory research projects to accomplish these goals.

小笼硼氢化物的生物活性衍生物 将在化学疗法中使用的部分将合成。 这 重点将是含有a的聚硼烷的合成 氮的附件类似于已经显示的氮 确认针对白血病P-388测试系统的活性。 功能将引入有希望的分子 试图改变这些系统的脂质溶解度。 硼化合物的结构关系将与 抗癌活性和其他药用应用。 两个 两个大学生和研究生 首席研究员将进行实验室研究项目 实现这些目标。