BEHAVIORAL AND PHYSIOLOGICAL CONTROL OF ETHANOL DRINKING

饮酒的行为和生理控制

• 批准号: 2000043
• 负责人: HERMAN H SAMSON
• 金额: $ 10.21万
• 依托单位: WAKE FOREST UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-01-01 至 2001-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2000043
• 关键词: alcoholic beverage consumption; alcoholism /alcohol abuse prevention; antisense nucleic acid; behavioral /social science research tag; dopamine; electrophysiology; gamma aminobutyrate; laboratory rat; microelectrodes; neural information processing; neurotransmitter agonist; neurotransmitter antagonist; operant conditionings

DESCRIPTION: The mechanisms involved in the control of ethanol consumption are becoming partially understood, through the work of many investigators over the last several years. Our laboratory has been involved for the last 15 years with understanding the interaction between behavioral, genetic, and CNS functions in both limited-access and continuous access drinking paradigms. Because of this K05 award for the last 5 years, I have been able to devote the major portion of my effort towards these studies. This competing renewal, will provide the continued salary support which will allow me to be primarily engaged in this research endeavor. The specific research aims which will be supported by this award are as follows: 1 Work on the specific aims in my current NIAAA RO1 and R37 supported awards (60% effort) will constitute a large portion of my research effort. 2. In addition, I plan to continue my studies on the effects of dopamine sensitization on ethanol drinking patterns. 3. Also, I will continue to develop the use of new molecular tools in my laboratory, including antisense technology. The use of these procedures will be able to provide additional information on the role of the mesolimbic dopamine system in the control of ethanol consumption.

描述：控制乙醇消耗的机制 通过许多调查人员的工作，人们已经成为部分理解 在过去的几年中。 我们的实验室参与了最后 15年，了解行为，遗传和 中枢神经系统在有限访问和连续访问饮酒中起作用 范式。 由于过去5年获得了K05奖，我能够 将我的主要努力的主要部分用于这些研究。 这 竞争更新，将提供持续的薪水支持 请允许我主要参与这项研究。 该奖项将支持的具体研究目的是 以下内容： 我目前的NIAAA RO1和R37支持奖项中有关特定目标的1项工作 （60％的努力）将构成我研究工作的很大一部分。 2。此外，我计划继续研究多巴胺的影响 对乙醇饮用模式的敏感性。 3。此外，我将继续在我的 实验室，包括反义技术。 这些程序的使用 将能够提供有关中唇的作用的其他信息 多巴胺系统控制乙醇消耗。