CENTER FOR THE NEUROBEHAVIORAL STUDY OF ALCOHOL

酒精神经行为研究中心

• 批准号: 6137011
• 负责人: HERMAN H SAMSON
• 金额: $ 119.22万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-01-01 至 2003-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6137011
• 关键词: behavioral /social science research tag; ethanol; neuropsychology; psychological reinforcement

The ability of alcohol (ethanol) to produce internal stimuli that direct appropriate behavior (i.e., discriminative stimuli) and maintain ethanol consumption (i.e., reinforcing stimuli) are fundamental processes postulated to be important for both normal drinking and excessive chronic alcohol use. However, how these ethanol stimulus effects are mediated within the central nervous system remains unclear. Work done by members of the proposed Center have elucidated several candidate neurobehavioral systems but a continued coordinated effort is needed to provide for the integration of the data from the molecular to the behavioral level of analysis. Using this already developed alcohol research team, the goals of the Center can be achieved. The Specific Aims are: 1. Provide an integrated, multi-disciplinary approach to study ethanol's discriminative and reinforcing stimulus effects. 2. Provide a national resource for the dissemination of research findings and training in the area of neurobehavioral analysis of ethanol's stimulus effects related to alcohol abuse and alcoholism. These aims are to be accomplished through the functions of an Administrative, Animal and Pilot Cores, and 5 projects which range from the molecular through the cellular to the behavioral levels of analysis.

酒精（乙醇）产生内部刺激的能力，该刺激指导适当的行为（即歧视性刺激）和维持乙醇消耗（即增强刺激）是基本的过程，认为对正常饮酒和过度慢性酒精的使用至关重要。然而，这些乙醇刺激作用如何在中枢神经系统中介导，尚不清楚。拟议中心成员所做的工作阐明了几个候选神经行为系统，但是需要继续协调的努力，以便整合分子到行为分析级别的数据。使用这个已经开发的酒精研究团队，可以实现该中心的目标。具体目的是：1。提供一种综合的多学科方法来研究乙醇的歧视性和增强刺激效应。 2.提供了一个国家资源，用于传播研究发现和培训与乙醇刺激效应有关的神经行为分析领域的研究结果和培训。这些目标将通过行政，动物和试点核的功能以及从分子到细胞到细胞的行为水平的5个项目来实现。