CORTICOCORTICAL INTERACTIONS IN VISION

视觉中的皮质相互作用

• 批准号: 2460452
• 负责人: Keith P. Purpura
• 金额: $ 7.13万
• 依托单位: WEILL MEDICAL COLL OF CORNELL UNIV
• 依托单位国家: 美国
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-08-04 至 1998-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2460452
• 关键词: Macaca fascicularis; attention; brain electrical activity; brain mapping; cell cell interaction; visual cortex; visual pathways; visual stimulus

Corticocortical interactions in the primate visual system will be investigated to learn about the nature of the communication between cortical areas and how cortical regions interact in the analysis of the visual world. Paired electrophysiological recordings will be made between striate and extrastriate areas V1/V4, V1/IT and V4/IT in the awake-behaving monkey. Similar experiments will be performed in anesthetized monkeys. Visual stimuli will consist of both broadband and bandlimited noise as well as stimuli that allow for a separation of cortical feature extraction mechanisms from those of simple spatial filtering. Spike trains and local field potentials recorded in two visual areas will be analyzed for crosscorrelation structure in the presence and absence of visual stimuli and in the presence and absence of visually guided behavior. Corticocortical interactions will be studied in three different behavioral contexts. 1) focused spatial attention; 2) selective feature attention; 3) perception of simultaneous contrast. Current models of cortical organization suggest that these behaviors should influence the interactions between disparate cortical areas. The timing and distribution of activity in the cortical laminae of V1 and V4 will be examined with multicontact electrodes in the anesthetized monkey. This study will resolve the role of descending projections from extrastriate cortex in the processing of visual form in area V1. The regional and laminar pattern of neurofibrillary tangles has led to the conclusion that the dementia associated with Alzheimer's disease is a consequence of a loss of corticocortical projections. The development of more accurate diagnostic techniques may well depend on a better understanding of the nature of corticocortical interactions in the primate brain.

灵长类动物视觉系统中的皮质皮质相互作用将是 调查以了解 皮质区域以及皮质区域如何在分析中相互作用 视觉世界。 配对的电生理记录将在条纹和 外部区域v1/v4，v1/it和v4/it在醒着的猴子中。 类似的实验将在麻醉猴子中进行。视觉的 刺激将包括宽带和频带的噪音以及 可以分离皮质特征提取的刺激 简单空间过滤的机制。尖峰火车和当地 将分析两个视觉区域记录的现场电位 在存在和不存在视觉刺激的情况下互相关结构 在存在和不存在视觉引导行为的情况下。 皮质皮质相互作用将以三种不同的行为进行研究 上下文。 1）集中注意力集中； 2）选择性功能关注； 3） 同时对比的感知。当前的皮质模型 组织建议这些行为应该影响 不同皮质区域之间的相互作用。 V1和 V4将使用麻醉的多接触电极检查 猴。这项研究将解决从 在区域V1中的视觉形式处理中，皮层外皮质。 神经纤维缠结的区域和层流模式导致了 结论与阿尔茨海默氏病有关的痴呆症是 损失皮质皮质预测的结果。发展的发展 更准确的诊断技术很可能取决于更好 了解灵长类动物中皮质皮质相互作用的性质 脑。