TEMPORAL CODES AND CORTICOCORTICAL COMMUNICATION

时间编码和皮质通讯

• 批准号: 2892301
• 负责人: Keith P. Purpura
• 金额: $ 18.21万
• 依托单位: WEILL MEDICAL COLL OF CORNELL UNIV
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-07-01 至 2002-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2892301
• 关键词: Macaca mulatta; attention; brain disorders; electrophysiology; evoked potentials; form /pattern perception; magnetic resonance imaging; microelectrodes; neural information processing; neurons; neurophysiology; occipital lobe /cortex; saccades; single cell analysis; space perception; temporal lobe /cortex; visual cortex; visual fields; visual stimulus

The broad aim of the proposed studies is to define the role of temporal codes in corticocortical information processing. Current models of coincidence detection and temporal integration of average firing rates are directly examined with an experimental approach. Pattern recognition and directing attention are chosen as related cortical functions which are likely to select for different processing strategies. Pattern recognition which requires fast, parallel and exhaustive, binding of multiple features within and across many scales is likely to depend on the fast timing schemes identified in coincidence detection models. Directing attention, on the other hand, reflects the deploying of a narrow information channel. This process is likely to depend on slower, serial search schemes that are well supported by rate coding strategies that mark more highly active neural sub-populations. Specific experimental methods are proposed to test the utilization of these strategies by neurons in the awake animal engaged in simple but well-defined behavioral tasks. The significance of these studies is to build our understanding of the nature of temporal processing in cortical dynamics. Knowledge of the mechanisms of temporal integration is the next crucial step in approaching the varied problems of brain injury. Increasing evidence points to the disruption of temporal processing as a fundamental mechanism underlying developmental and acquired cognitive disabilities. Morever, the first hints of therapeutic approaches based on models of temporal processing suggest that further detailed knowledge of the timing of information flow in the cortex will assist the efforts to improve the lives of patients with dyslexia, head trauma and stroke. Ultimately, the brain is organized with parallel and vertical subcortical connections (limbic, striatal, thalamocortical) as well as the corticocortical connections emphasized here. The studies proposed will seek to frame the understanding of corticocortical interactions in a context that will support further studies of thalamocortical integration. Building out from this framework will enlarge the possible scope of significance for the treatment of brain disorders.

拟议研究的广泛目的是定义时间的作用 皮质皮质信息处理中的代码。当前的模型 平均点火率的巧合检测和时间整合 通过实验方法直接检查。 图案 选择识别和引导注意作为相关皮质 可能选择不同处理的功能 策略。 模式识别需要快速，平行和 详尽的，在许多尺度内和多个特征的结合 可能取决于巧合所确定的快速计时方案 检测模型。 另一方面，指导注意力反映了 部署狭窄的信息渠道。 这个过程可能会 取决于速度较慢的串行搜索方案，这些方案得到了速率的良好支持 编码策略标志着更高度活跃的神经子群。 提出了特定的实验方法来测试利用 神经元在清醒动物中的这些策略从事简单但 定义明确的行为任务。 这些研究的意义是建立我们对 皮质动力学中时间处理的性质。了解 时间整合的机制是下一个关键步骤 解决脑损伤的各种问题。越来越多的证据 指出时空处理的破坏是基本的 发展和获得认知障碍的机制。 此外，是基于模型的治疗方法的第一批提示 时间处理表明，进一步详细了解 皮质中信息流的时间流将有助于努力 改善阅读障碍，头部创伤和中风患者的生活。 最终，大脑是平行和垂直的 皮质下连接（边缘，纹状体，丘脑皮质）以及 这里强调的皮质皮层连接。 研究提出 将寻求构建对皮质皮质相互作用的理解 将支持丘脑皮质的进一步研究的环境 一体化。 从这个框架建立将扩大可能的 脑疾病治疗的显着范围。