PREVENTIVE ONCOLOGY ACADEMIC AWARDS

预防肿瘤学学术奖

• 批准号: 2414460
• 负责人: LISA J HERRINTON
• 金额: $ 9.79万
• 依托单位: KAISER FOUNDATION RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-05-01 至 2001-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2414460
• 关键词: HIV infections; adolescence (12-20); automated medical record system; body height; breast neoplasms; cancer prevention; cancer registry /resource; cancer risk; clinical research; cryptorchidism; female; human data; longitudinal human study; male; male reproductive system surgery; middle childhood (6-11); neoplasm /cancer classification /staging; neoplasm /cancer epidemiology; nonHodgkin's lymphoma; smoking; testis neoplasms

The research has focused on multiple myeloma, a B-cell malignancy. Career goals are to expand knowledge of B-cell neoplasia to include non-Hodgkin's lymphoma (NHL) and to use training in laboratory science to study molecular markers of exposure. To obtain the training and experience needed to become an independent investigator with emphasis in these areas, it is planned to: 1. Audit Immunology and Molecular Epidemiology courses at Stanford University; 2. Write a review article on the epidemiology of NHL subtypes; 3. Use existing computerized data to investigate the demographic occurrence of NHL subtypes, and the role of smoking and HIV infection in NHL; and, 4. Write a methodological article outlining design trade-offs to minimize information bias in epidemiologic research using laboratory-based measurements. A major strength of conducting research at Kaiser Permanente stems from the long-term follow-up of patients. Prospective information on physical and medical characteristics can be quickly obtained from the medical record. It is proposed to take advantage of this strength and collect original data to evaluate two hypotheses: 5. Is relatively tall height-for-age in girls aged 8 to 18 years associated with the subsequent risk of epithelial breast cancer? 6. Does surgical correction of cryptorchidism (orchidopexy) at a relatively young age reduce the risk of germ-cell testicular cancer to a greater extent than if the correction is made later?

该研究集中在多发性骨髓瘤（B细胞恶性肿瘤）上。 职业 目标是将B细胞肿瘤的知识扩展到包括非霍奇金的知识 淋巴瘤（NHL）并使用实验室科学培训来研究 暴露的分子标记。 获得培训和经验 需要成为一名独立研究者，重点是这些领域， 计划： 1。斯坦福大学的审计免疫学和分子流行病学课程 大学; 2。撰写有关NHL亚型流行病学的评论文章； 3。使用现有的计算机数据调查人口统计 NHL亚型的发生以及吸烟和HIV感染的作用 NHL;和， 4。写一篇方法论文章，概述设计权衡以最大程度地减少 使用基于实验室的流行病学研究中的信息偏见 测量。 在Kaiser Permanente进行研究的主要优势源于 患者的长期随访。 有关身体的前瞻性信息 可以从医疗中快速获得医疗特征 记录。 有人建议利用这一优势并收集 评估两个假设的原始数据： 5。在8至18岁的女孩中相对较高 与随后发生上皮乳腺癌的风险有关？ 6。在A的手术校正（在 相对年轻的年龄降低了生菌睾丸癌的风险 比以后进行更正的程度更大？