Adverse childhood experiences and alcohol misuse in Latino adolescents: testing biopsychosocial and cultural mechanisms supplement

拉丁裔青少年的不良童年经历和酒精滥用：测试生物心理社会和文化机制补充

• 批准号: 10873557
• 负责人: Jenny Zhen-Duan
• 金额: $ 7.56万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-07-01 至 2024-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10873557
• 关键词: Adolescent; Alcohol consumption; Award; Birth; Budgets; Child; Child Health; Childbirth; DNA Methylation; Data; Data Collection; Enrollment; Epigenetic Process; Event; Funding; Goals; Hair; Hour; Hydrocortisone; Latino; Life; Link; Manuscripts; Maternity leave; Participant; Phase; Productivity; Publishing; Research; Research Assistant; Risk Factors; Role; Saliva; Testing; Time; Training; adverse childhood events; alcohol misuse; biopsychosocial; cost; data management; hypothalamic-pituitary-adrenal axis; medical complication; protective factors; recruit

Project Summary The purpose of this K supplement is to request support following the impending critical life event of childbirth. I was awarded the K08 award in February 2022 and gave birth to my first child in June 2022. During these four months, I hired and trained a research assistant, started data collection, and promptly went on maternity leave. Given budgetary constraints, I am only able to pay for 10 hours a week of a research assistant’s time, which is exclusively focused on recruitment and data collection. The K08 aims are to 1) identify risk and protective factors in the ACEs-alcohol use link, 2) evaluate the role of HPA axis functioning (hair cortisol) in the ACEs- alcohol misuse link and identify relevant protective factors and 3) explore epigenetic mechanisms (saliva DNA methylation) linking ACEs and HPA axis functioning. Despite my child’s health problems and the limited research assistant support, I have made significant progress on my K08 project, including enrolling 140 of the 150 target participants in a year, completing coursework at Harvard, engaging in local and national presentations, and publishing 15 co-authored manuscripts. However, despite the excellent progress on my K08 goals, it has been done at an unsustainable pace, particularly given my child’s medical complications. Therefore, the purpose of my K08 Supplement application is to request funding for me to hire a full-time research assistant and fund a part-time biostatistician. The research assistant and biostatistician will assist me with the duties I am assuming right now and will help with additional activities in the next project phases (e.g., data management, analysis, publishing preliminary data) and support me in my goal to submit my first R01 this upcoming year. Given that epigenetic analysis is so costly, I have had to allocate most of my earlier years of the research budget towards epigenetic analysis. However, my budget during years 3.5-5 are almost exclusively allocated to fund their time, so I should be able to return to full productivity at the end of the supplemental period.

项目摘要 该K补充剂的目的是在即将到来的分娩关键生活事件之后请求支持。 我于2022年2月获得了K08奖，并于2022年6月生下了我的第一个孩子。 几个月，我聘请并培训了一名研究助理，开始了数据收集，并立即休产假。 给定预算限制，我只能每周支付10个小时的研究助理时间，这是 仅专注于招聘和数据收集。 K08的目的是1）确定风险并保护 Aces-Alcohol使用链接中的因素，2）评估HPA轴功能（毛皮质醇）在ACES-的作用 酒精滥用联系并确定相关的受保护因素，3）探索表观遗传机制（唾液DNA 甲基化）连接ACE和HPA轴功能。尽管我孩子的健康问题和有限 研究助理支持，我在我的K08项目上取得了重大进展，包括注册140个 一年中的150名目标参与者，在哈佛完成课程，从事当地和国家 演讲，并出版了15个共同作品的手稿。但是，尽管我的K08取得了出色的进步 目标是在不可持续的空间中完成的，尤其是考虑到我孩子的医疗并发症。 因此，我的K08补充申请的目的是要求我雇用全职的资金 研究助理并资助兼职生物统计学家。研究助理和生物统计学家将帮助我 我现在要承担的职责，并将在下一个项目阶段进行其他活动（例如， 数据管理，分析，发布初步数据）并支持我的目标，以提交我的第一个R01 即将到来的一年。鉴于表观遗传分析是如此昂贵，所以我不得不分配我早期的大部分时间 研究预算对表观遗传分析。但是，我在3.5-5年的预算几乎完全是 分配给他们的时间，因此我应该能够在补充期结束时恢复全部生产力 时期。