BLR&D Research Career Scientist Award Application

BLR

• 批准号: 10618271
• 负责人: JIALING LIU
• 金额: --
• 依托单位: VETERANS AFFAIRS MED CTR SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-04-01 至 2024-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10618271
• 关键词: Ablation; Adult; Adverse effects; Affect; Area; Award; Basic Science; Blood Vessels; Blood flow; Bone Marrow; Brain; Brain Injuries; Brain region; Cells; Cerebral Ischemia; Cerebrum; Collaborations; Communities; Core Facility; Data; Defect; Development; Diabetes Mellitus; Diabetic mouse; Differentiation and Growth; Disease; Electrophysiology (science); Faculty; Functional disorder; Funding; General Population; Goals; Health; Healthcare; Hippocampus; Hypoglycemia; Image; Immune; Impairment; Incidence; Inflammation; Injury; Insulin Resistance; International; Intervention; Ischemic Stroke; Lesion; Light; Location; Maps; Mediating; Medical; Mentors; Metabolic; Metabolic syndrome; Microcirculatory Bed; Mission; Modality; Motor; Natural Immunity; Natural regeneration; Neuronal Plasticity; Neurons; Neurosciences; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Optical Coherence Tomography; Paper; Parietal Lobe; Pathway interactions; Peer Review; Population; Postdoctoral Fellow; Prevalence; Productivity; Professional Organizations; Proliferating; Publications; Publishing; Recovery; Recovery of Function; Rehabilitation therapy; Research; Research Activity; Research Personnel; Rest; Risk; Scientist; Seminal; Services; Severities; Stroke; TBI treatment; Technology; Therapeutic Intervention; Thrombophilia; Traumatic Brain Injury; Uncertainty; United States National Institutes of Health; Universities; Vascular remodeling; Velocimetries; Veterans; Work; career; cognitive function; connectome; effective therapy; experimental study; extracellular; extracellular vesicles; gene therapy; imaging modality; improved; in vivo; insight; interdisciplinary approach; interest; loss of function; metabolic abnormality assessment; military veteran; nerve stem cell; neural; neurobehavioral; neurogenesis; neuroprotection; novel; novel imaging technique; peripheral blood; pharmacologic; post stroke; programs; recruit; regenerative therapy; repaired; response; stem cells; stroke outcome; targeted treatment; tool; transcriptome; vascular risk factor

The current research activities of Dr. Jialing Liu seek to understand how the brain responds to injuries caused by ischemic stroke, hypoglycemia or traumatic brain injury (TBI). The overarching goal of her research sought to better the understanding of how vascular risk factors and metabolic syndrome increase the risk of ischemic stroke and worsen the outcome of stroke, in order to develop effective therapies to improve the recovery and function. Her main research areas are summarized as the following topics: (1) Neurogenesis and functional recovery after brain injury; (2) Cerebral ischemia and neuroprotection; (3) Regeneration and rehabilitation therapy for TBI; (4) Development of novel imaging modality to assess collateral blood flow and vascular remodeling; (5) Innate immunity in response to stroke injury and metabolic inflammation; (6) Brain network and connectivity analysis; and (7) Assessing neural activity via in vivo multichannel electrophysiology. Dr. Liu has be able to incorporate cutting edge technology to advance her research. Many of her research programs have emerged since the beginning of this past RCS funding cycle and have evolved into productive work as demonstrated by peer reviewed publications, federal funding in VA and NIH awards. Since stroke, diabetes and TBI are major and unmet medical conditions among the veterans, her work in finding the mechanisms and effective therapies for these diseases will no doubt have a great impact on VA healthcare as well as on the advancement in basic research in her field. Besides keeping a productive research activity, Dr. Liu has established broad collaboration with investigators at her local VA and affiliate university, some of which have resulted in peer reviewed publications and federal funding. The recognition of her work has reached international community, so has been her collaborative research. She has also mentored a large number of scientists including junior faculty, post doctoral researchers and young scientists. Apart from her service to national VA and the professional societies, she has invaluable contribution in the neuroscience program of SFVA by being the scientific director of the neurobehavioral core facility. Currently she is serving her second term at the UCSF faculty council by representing the SFVA research community and improving the research interface between the VA and UCSF.

Jialing Liu博士的当前研究活动试图了解大脑的反应 缺血性中风，低血糖或创伤性脑损伤（TBI）造成的伤害。这 她的研究的总体目标试图更好地了解血管风险因素如何 代谢综合征增加了缺血性中风的风险，并使中风的结果恶化， 为了开发有效的疗法以改善恢复和功能。她的主要研究 区域总结为以下主题：（1）神经发生和功能恢复 脑损伤； （2）脑缺血和神经保护； （3）再生和康复 TBI治疗； （4）开发新型成像方式，以评估副血流和 血管重塑； （5）响应中风损伤和代谢的先天免疫力 炎; （6）大脑网络和连通性分析； （7）通过 体内多通道电生理学。刘博士能够融入尖端 推进她的研究的技术。自从她的许多研究计划已经出现 从过去的RCS资金周期开始，并已演变为生产性工作 由同行评审出版物，弗吉尼亚州的联邦资金和NIH奖项展示。自从 中风，糖尿病和TBI是退伍军人的主要且未满足的医疗状况，她的工作 在寻找这些疾病的机制和有效疗法时，无疑会有很大的 对VA医疗保健以及其领域基础研究进步的影响。除了 刘博士保持了富有成效的研究活动，与 她当地的弗吉尼亚大学和会员大学的调查员，其中一些导致了同伴 审查出版物和联邦资金。她的工作的认可已达到 国际社会，她的合作研究也是如此。她还指导了一个大的 包括初级教师，博士后研究人员和年轻科学家在内的科学家人数。 除了为国家弗吉尼亚州和专业社会提供服务外，她的宝贵 SFVA神经科学计划的贡献是作为科学主任 神经行为核心设施。目前，她在UCSF教师任职 理事会代表SFVA研究界并改善研究界面 在VA和UCSF之间。