BLR&D Research Career Scientist Award Application

BLR

• 批准号: 9911967
• 负责人: JIALING LIU
• 金额: --
• 依托单位: VETERANS AFFAIRS MED CTR SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-04-01 至 2024-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9911967
• 关键词: Ablation; Adult; Adverse effects; Affect; Area; Award; Basic Science; Blood flow; Bone Marrow; Brain; Brain Injuries; Brain region; Cells; Cerebral Ischemia; Cerebrum; Collaborations; Communities; Core Facility; Data; Defect; Development; Diabetes Mellitus; Diabetic mouse; Differentiation and Growth; Disease; Electrophysiology (science); Faculty; Functional disorder; Funding; General Population; Goals; Health; Healthcare; Hippocampus (Brain); Hypoglycemia; Image; Immune; Impairment; Incidence; Inflammation; Injury; Insulin Resistance; International; Intervention; Ischemic Stroke; Lead; Lesion; Light; Location; Maps; Mediating; Medical; Mentors; Metabolic; Metabolic syndrome; Microcirculatory Bed; Mission; Modality; Motor; Natural Immunity; Natural regeneration; Neuronal Plasticity; Neurons; Neurosciences; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Optical Coherence Tomography; Paper; Parietal Lobe; Pathway interactions; Peer Review; Pharmacology; Population; Population Research; Postdoctoral Fellow; Prevalence; Professional Organizations; Publications; Publishing; Recovery of Function; Rehabilitation therapy; Research; Research Activity; Research Personnel; Rest; Risk; Scientist; Seminal; Services; Severities; Stroke; TBI treatment; Technology; Therapeutic Intervention; Thrombophilia; Traumatic Brain Injury; Uncertainty; United States National Institutes of Health; Universities; Vascular remodeling; Velocimetries; Veterans; Work; base; career; cognitive function; connectome; effective therapy; experimental study; extracellular; extracellular vesicles; gene therapy; imaging modality; improved; in vivo; insight; interdisciplinary approach; interest; loss of function; metabolic abnormality assessment; nerve stem cell; neurobehavioral; neurogenesis; neuroprotection; novel; novel imaging technique; peripheral blood; post stroke; programs; recruit; regenerative therapy; relating to nervous system; repaired; response; stem cells; stroke outcome; targeted treatment; tool; transcriptome; vascular risk factor

The current research activities of Dr. Jialing Liu seek to understand how the brain responds to injuries caused by ischemic stroke, hypoglycemia or traumatic brain injury (TBI). The overarching goal of her research sought to better the understanding of how vascular risk factors and metabolic syndrome increase the risk of ischemic stroke and worsen the outcome of stroke, in order to develop effective therapies to improve the recovery and function. Her main research areas are summarized as the following topics: (1) Neurogenesis and functional recovery after brain injury; (2) Cerebral ischemia and neuroprotection; (3) Regeneration and rehabilitation therapy for TBI; (4) Development of novel imaging modality to assess collateral blood flow and vascular remodeling; (5) Innate immunity in response to stroke injury and metabolic inflammation; (6) Brain network and connectivity analysis; and (7) Assessing neural activity via in vivo multichannel electrophysiology. Dr. Liu has be able to incorporate cutting edge technology to advance her research. Many of her research programs have emerged since the beginning of this past RCS funding cycle and have evolved into productive work as demonstrated by peer reviewed publications, federal funding in VA and NIH awards. Since stroke, diabetes and TBI are major and unmet medical conditions among the veterans, her work in finding the mechanisms and effective therapies for these diseases will no doubt have a great impact on VA healthcare as well as on the advancement in basic research in her field. Besides keeping a productive research activity, Dr. Liu has established broad collaboration with investigators at her local VA and affiliate university, some of which have resulted in peer reviewed publications and federal funding. The recognition of her work has reached international community, so has been her collaborative research. She has also mentored a large number of scientists including junior faculty, post doctoral researchers and young scientists. Apart from her service to national VA and the professional societies, she has invaluable contribution in the neuroscience program of SFVA by being the scientific director of the neurobehavioral core facility. Currently she is serving her second term at the UCSF faculty council by representing the SFVA research community and improving the research interface between the VA and UCSF.

刘嘉玲博士目前的研究活动旨在了解大脑如何响应 缺血性中风、低血糖或创伤性脑损伤 (TBI) 引起的损伤。这 她研究的总体目标是更好地了解血管危险因素如何 代谢综合征会增加缺血性中风的风险并使中风的结果恶化， 以开发有效的疗法来改善康复和功能。她的主要研究 领域概括为以下主题：（1）神经发生和术后功能恢复 脑损伤； (2)脑缺血与神经保护； (3)再生与康复 TBI 治疗； (4) 开发新的成像方式来评估侧支血流和 血管重塑； (5) 应对中风损伤和代谢的先天免疫 炎; (6) 脑网络及连通性分析； (7) 通过评估神经活动 体内多通道电生理学。刘博士能够将尖端技术融入 技术来推进她的研究。她的许多研究项目自 过去 RCS 资助周期的开始，并已发展成为富有成效的工作 同行评审出版物、VA 和 NIH 奖项的联邦资助证明了这一点。自从 中风、糖尿病和创伤性脑损伤是退伍军人中主要且未得到满足的医疗状况，她的工作 寻找这些疾病的机制和有效疗法无疑将具有重大意义 对 VA 医疗保健以及该领域基础研究进步的影响。除了 刘博士保持了富有成效的研究活动，与以下机构建立了广泛的合作 她当地的退伍军人事务部和附属大学的调查人员，其中一些调查结果导致了同行 审查出版物和联邦资金。她的作品的认可度已达 国际社会，她的合作研究也是如此。她还指导过大批 包括初级教师、博士后研究人员和青年科学家在内的科学家数量。 除了为国家退伍军人事务部和专业协会提供服务外，她还拥有宝贵的 作为 SFVA 的科学主任，对 SFVA 的神经科学项目做出了贡献 神经行为核心设施。目前，她正在加州大学旧金山分校任教，这是她的第二个任期 代表 SFVA 研究界并改进研究界面的理事会 VA 和 UCSF 之间。