Bio Science Facility Core

生物科学设施核心

基本信息

批准号：
10617829
负责人：
ROBERT C BURGHARDT
金额：
$ 5.3万
依托单位：
TEXAS A&M UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-05-01 至 2025-03-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10617829
关键词：
3-Dimensional Acceleration Animal Experiments Animals Back Bioinformatics Biological Biometry Cells Collaborations Communities Core Facility Cultured Cells Data Science Data Set Development Disease Doctor of Philosophy Environment Environmental Exposure Environmental Health Environmental Impact Environmental Risk Factor Equipment Functional Imaging Generations Genes Genetic Determinism Goals Health Health Sciences Human Human Resources Image Imaging technology In Vitro Information Retrieval Infrastructure Interdisciplinary Study Investments Link Measures Mentors Modeling Molecular Nature Organoids Pattern Phenotype Physiological Physiology Population Positioning Attribute Predisposition Procedures Public Health Research Research Activity Research Personnel Resources Risk Science Services Specialist System Target Populations Technology Testing Texas Tissues Toxic effect Toxicology Training Translating Translational Research Translations Vision community engagement cost effective data management data mining data sharing design experience in vivo in vivo Model indexing innovation insight instrumentation member metabolic phenotype molecular phenotype novel organ on a chip structural imaging

项目摘要

Bio Science Facility Core (BSFC) ABSTRACT A major goal of the Texas A&M Center for Environmental Health Research (TiCER) is to evaluate the effects of toxicological agents present in the environment on target populations. The ability to quantify biological effects of different exposures is critical to understanding and interpreting the health impact of environmental exposures. The Bio Science Facility Core (BSFC) will provide Center members access to key enabling technologies and expertise to support the vision of the Center “Enhancing Public Health by Identifying, Understanding and Reducing Adverse Environmental Health Risks.” This will be accomplished by providing access to state-of-the- art analytical technology, infrastructure, and expertise to perform mechanistic research on environmental factors that impact human health and disease. The BSFC will integrate imaging, molecular, and physiological phenotyping capabilities, which are currently distributed across the Texas A&M campus, to support multi-scale research into the underlying mechanisms of environmental health risks, from single cells and organoids to experimental animal populations. The BSFC will achieve this goal by: (1) Maintaining a wide range of state-of- the-art technologies and expertise to enhance environmental health research integration and translation; (2) Providing subsidized and prioritized access to expertise with analytical technologies through training, consulting services, applications development, and mentoring; and (3) Facilitating translational research activities to enhance the capacity, breadth, collaborative nature, and impact of environmental health research. The BSFC will provide expertise and analytical equipment to measure a continuum of phenotypic readouts ranging from the single-cell level to population-scale models. The leaders of the BSFC have an established track record of collaborative, interdisciplinary, and translational research, and are well positioned to facilitate the technology needs of Center members to increase research efficiency and facilitate sharing of experimental procedures.

生物科学设施核心 (BSFC) 摘要德克萨斯 A&M 环境健康研究中心 (TiCER) 的一个主要目标是评估影响环境中存在的毒物对目标人群的影响的能力。不同暴露的影响对于理解和解释环境暴露对健康的影响至关重要。生物科学设施核心（BSFC）将为中心成员提供关键支持技术和专业知识来支持该中心的愿景“通过识别、理解和促进公共卫生” “减少不利的环境健康风险。” 对环境因素进行机械研究的艺术分析技术、基础设施和专业知识 BSFC 将整合成像、分子和生理学。表型分析能力目前分布在德克萨斯农工大学校园内，以支持多尺度研究环境健康风险的潜在机制，从单细胞和类器官到 BSFC 将通过以下方式实现这一目标： (1) 维持广泛的状态-- 加强环境健康研究整合和转化的最先进技术和专业知识（2）通过培训、咨询，提供有补贴和优先获得分析技术专业知识的机会服务、应用程序开发和指导；(3) 促进转化研究活动提高环境健康研究的能力、广度、协作性质和影响力。将提供专业知识和分析设备来测量一系列表型读数 BSFC 的领导者拥有从单细胞水平到群体规模模型的良好记录。协作、跨学科和转化研究，并处于促进技术发展的有利位置中心成员需要提高研究效率并促进实验程序共享。