HIVR4P 2023, the 5th HIV Research for Prevention Conference, Lima, Peru, and virtually, 22-26 October 2023

HIVR4P 2023，第五届艾滋病毒预防研究会议，秘鲁利马，虚拟会议，2023 年 10 月 22-26 日

• 批准号: 10617933
• 负责人: Christopher C. Beyrer
• 金额: $ 140万
• 依托单位: IAS
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-03-01 至 2025-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10617933
• 关键词: AIDS prevention; Address; Adherence; Adolescent and Young Adult; Affect; African; Applied Research; Area; Attention; Basic Science; Brazil; COVID-19; COVID-19 pandemic; COVID-19 vaccine; Calibration; Cities; Clinical Trials; Collaborations; Communities; Complex; Country; Dapivirine; Disparity; Drug user; Effectiveness; Emergency response; Epidemic; Epidemiology; Face; Financial Support; Formulation; Fostering; Goals; Government; HIV; HIV Infections; HIV vaccine; Hearing; Hybrids; Incidence; Indigenous; Individual; Infection; Injectable; Injecting drug user; Injections; International; Intervention; Knowledge; Latin American; Leadership; Learning; Light; Male Circumcision; Maps; Misinformation; Modality; Oral; Outcome; Overdose; Participant; Pathway interactions; Persons; Peru; Population; Populations at Risk; Prevention; Prevention Research; Prevention program; Prevention trial; Primary Prevention; Provider; Public Health; Reporting; Research; Research Personnel; Risk; Role; Rural; Science; Scientific Advances and Accomplishments; Scientist; System; Technology; Therapeutic; Time; Travel; Vaccine Research; Vaccines; Vaginal Ring; Woman; Work; Writing; community barrier; cost; design; disinformation; efficacy trial; girls; implementation science; innovation; low and middle-income countries; men; men who have sex with men; multidisciplinary; neutralizing antibody; new technology; next generation; novel; novel strategies; personalized approach; pre-exposure prophylaxis; prevent; programs; response; sex; small molecule; substance use; substance user; suburb; success; symposium; synergism; transgender; transmission process; uptake; vaccine hesitancy; virtual; willingness

Project Summary UNAIDS set ambitious prevention goals and targets for HIV incidence reductions for 2020. We were not on a trajectory for success for those goals before the COVID-19 pandemic, and are at risk of further expansion of HIV epidemics. Declines in surveillance capacity also threaten our ability to assess HIV epidemic trajectories in many settings of risk. We face daunting challenges of ongoing transmission, and of growing gaps and disparities in primary prevention. Yet the existing and expanding toolkit for biomedical prevention of HIV infection has never had as much diversity, and as many high efficacy options, as today. Adolescents and younger adults in African settings and in key populations globally continue to bear the greatest burdens of HIV incidence, and to have the greatest challenges using and benefitting from biomedical HIV prevention advances. This population will be at the center of HIVR4P 2023. A particular focus will also be made on people who inject drugs or who use substances in sexual settings and have been understudied and underserved in HIV prevention. In the field of HIV vaccines, the COVID-19 pandemic highlighted new threats in terms of vaccines hesitancy. It is time now to investigate and report on new ways to addressing hesitancy and to understanding barriers to the uptake of novel HIV vaccines, prevention technologies and approaches. HIVR4P 2023, the 5th HIV Research for Prevention Conference taking place from 22 to 26 October 2023 in Lima, Peru, will be an opportunity for the HIV prevention community to hear, debate and weigh new scientific evidence, and to assess the increasingly complex prevention landscape and the next generation of research questions, including those for HIV vaccines, and the interactions of vaccines with non-vaccine prevention modalities. Lima was chosen as the host city to highlight scientific excellence in prevention research in the Latin American region while also drawing attention to the spiraling vulnerabilities and epidemics in the region. To facilitate everyone’s access to the conference regardless of their ability or willingness to travel, and recognizing that potential obstacles - including access to COVID-19 vaccines - might prevent key stakeholders particularly from countries with a high burden of HIV from travelling internationally, HIVR4P 2023 will be a fully hybrid conference. It will connect the two audiences both in Lima, which will provide a compelling venue for HIVR4P 2023 as a leading center of HIV prevention science, and online via the virtual conference platform. Specific aims for HIVR4P 2023 are to: 1. Convene the world’s experts in HIV prevention and related fields to advance scientific knowledge, present new research findings, and enhance global scientific and community collaborations 2. Advance HIV prevention technologies and implementation approaches that are tailored to the needs of those most at risk including adolescents and young adults, men who have sex with men, people who use drugs, sex workers, and transgender people globally, and women and girls in high-burden settings 3. Refine HIV prevention research agendas to reflect identified opportunities and knowledge gaps, including: Next generation HIV vaccines and bNAbs; hesitancy and misinformation; smarter delivery systems for small molecules, including longer-acting PrEP, depo formulation and multi-purpose technologies 4. Assess the state of the art of HIV vaccine research in light of the remarkable success of the COVID-19 vaccine enterprise, including the role of non-vaccine interventions in the next generation of HIV vaccine efficacy trials. The scientific program will consist of five thematic areas: basic science; PrEP and ARV-based prevention; Vaccines and bNAbs clinical trials; other prevention modalities and cross-cutting issues; applied and implementation science. The scientific program is developed by a multi-disciplinary international Organizing Committee. Cross-cutting aspects will be highlighted in plenary talks that also connect the science with community and leadership perspectives. Additionally, bridging sessions are designed to cut across the different thematic areas to provide opportunities for multi-disciplinary, multi-perspective dialogues, often using interactive formats. The participation of young researchers, basic scientists and researchers in related fields will be strengthened by active solicitation of relevant science and the provision of specific financial support, in addition to remote-access options. Key science from the conference will be disseminated and discussed in regional contexts following HIVR4P 2023.

项目摘要 联合国艾滋病规定设定了雄心勃勃的预防目标和2020年艾滋病毒事件减少的目标。我们没有 在COVID-19大流行之前为这些目标取得成功的轨迹，并有进一步扩大艾滋病毒的风险 情节。监视能力的下降也威胁着我们评估许多人在许多人中评估HIV流行轨迹的能力 风险设置。我们面临着正在进行的传播的挑战，以及越来越多的差距和差异 初级预防。然而，现有的和不断扩大的用于预防艾滋病毒感染的工具包 与今天一样多样性和许多高效率选择。非洲的青少年和年轻人 环境和全球关键人口继续承担最大的艾滋病毒伯恩斯事件，并拥有 使用并受益于预防生物医学艾滋病毒的最大挑战。这个人口将在 HIVR4P 2023的中心。还将特别关注注射毒品或使用的人 性环境中的物质，在艾滋病毒预防中已被理解和服务不足。在 艾滋病毒疫苗，19009年的大流行强调了疫苗犹豫不决的新威胁。现在是时候了 调查并报告解决新方法的新方法，并了解吸收新颖的障碍 艾滋病毒疫苗，预防技术和方法。 HIVR4P 2023，第五届HIV预防会议研究，于2023年10月22日至26日在 秘鲁利马将是艾滋病毒预防社区的机会 证据，并评估日益复杂的预防景观和下一代研究 问题，包括艾滋病毒疫苗的问题，以及疫苗与预防疫苗的相互作用 方式。利马被选为主办城市，以突出拉丁语的预防研究的科学卓越 美国地区同时还要注意该地区螺旋式漏洞和发作。 不管他们有能力或旅行意愿，都可以促进每个人参加会议的机会，并且 认识到潜在的障碍 - 包括获得COVID -19疫苗的机会 - 可能会阻止关键利益相关者 特别是来自国际旅行的艾滋病毒燃烧量高的国家，HIVR4P 2023将是一个完全 混合会议。它将连接利马的两个受众，这将为一个引人注目的场地提供 HIVR4P 2023是HIV预防科学的领先中心，并通过虚拟会议平台在线。 HIVR4P 2023的具体目标是： 1。召集世界上的艾滋病毒预防和相关领域的专家，以提高科学知识， 目前的新研究发现，并增强全球科学和社区合作 2。预防艾滋病毒预防技术和实施方法是根据需求量身定制的 那些处于危险中的人，包括青少年和年轻人，与男人发生性关系的男人，使用的人 全球毒品，性工作者和跨性别者，以及在高负荷环境中的妇女和女孩 3。改进HIV预防研究议程，以反映确定的机会和知识差距，包括： 下一代HIV疫苗和BNABS；犹豫不决和错觉；小型的智能交付系统 分子，包括长效准备，DEPO公式和多用途技术 4。根据Covid-19的显着成功，评估HIV疫苗研究的艺术状况 疫苗企业，包括非疫苗干预在下一代HIV疫苗中的作用 功效试验。 科学计划将由五个主题领域组成：基础科学；基于准备和基于ARV的预防； 疫苗和BNABS临床试验；其他预防方式和横切问题；应用和 实施科学。科学计划是由多学科国际组织制定的 委员会。全体会议中将强调横切方面，这也将科学与 社区和领导观点。此外，桥接会话旨在切入不同的 主题领域，为多学科的多学科对话提供机会，经常使用互动 格式。年轻研究人员，基础科学家和研究人员参与相关领域的参与将是 通过积极的相关科学和提供特定财务支持来加强 到远程访问选项。会议的重要科学将在区域传播和讨论 HIVR4P 2023之后的上下文。