Specific Pathogen Free 18 Baboon Research Resource (SPF18BRR)

无特定病原体 18 狒狒研究资源 (SPF18BRR)

• 批准号: 10912917
• 负责人: WILLIAM D HOPKINS
• 金额: $ 27.01万
• 依托单位: UNIVERSITY OF TX MD ANDERSON CAN CTR
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-08-15 至 2028-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10912917
• 关键词: 15 year old; 3 year old; Address; Adult; Age; Aging; Alzheimer' s disease related dementia; Animal Experimentation; Animal Model; Animals; Applied Research; Bacteremia; Bacterial Model; Biocompatible Materials; Biological; Biological Markers; Biology; Biomedical Research; Breeding; COVID-19 pneumonia; COVID-19 vaccine; Caregivers; Cognition; Communities; DNA Methylation; Data; Data Management Resources; Databases; Development; Diabetes Mellitus; Discipline; Doctor of Philosophy; Epigenetic Process; Family suidae; Female; Foundations; Future; General Population; Genetic; Genetic Engineering; Genetic Variation; Genomics; Goals; Grant; Health Sciences; Immunobiology; Intramural Research Program; Laboratory Animals; Methods; Modeling; Monitor; Neurosciences; Oklahoma; Papio; Papio anubis; Pertussis; Pharmacologic Substance; Plasma; Primates; Privatization; Production; Research; Research Contracts; Research Personnel; Research Project Grants; Resources; Respiratory syncytial virus; Scientist; Services; Students; System; Tissues; Training; Training and Education; United States National Institutes of Health; Universities; Veterinarians; Virus; Work; Xenograft procedure; age group; animal breeding; animal care; animal resource; cognitive testing; design; genetic analysis; genetic pedigree; genome sequencing; germ free condition; human disease; human model; improved; male; next generation; nonhuman primate; novel; offspring; pathogen; programs; social; tool; training opportunity; virus resource; web site; whole genome

PROJECT SUMMARY: OVERALL COMPONENT This application is a competing renewal of the “Specific Pathogen Free 18 Baboon Research Resource” (SPF18BRR) P40 OD024628. The SPF18BRR was founded with NIH support at the University of Oklahoma Health Sciences Center (OUHSC) in 2002 and was relocated to the Keeling Center in 2017. The SPF18BRR has received continuous NIH support since it was founded. The SPF18BRR is the only national research resource of adventitious virus free olive baboons (Papio anubis) that are available to NIH grantees; intramural research programs of federal agencies, including the FDA, NSF and NIH; and other sponsors of biomedical research (private foundations, pharmaceutical companies, and contract research organizations). Absolutely unique in the entire world, the baboons in the SPF18BRR have an extensive bioexclusion list of 18 pathogens normally found in other wild and captive nonhuman primate colonies. The SPF18BRR has integrated multiple disciplines into a program designed to meet the needs of investigators who utilize its resources. During the proposed period of support, the SPF18BRR will continue to improve the resources it provides to users and will continue to add new information about the biology and research value of virus free baboons to its website. Baboons continue to be important animal model for genetically engineered pig xenotransplantation, are the only NHP model of respiratory syncytial virus and whooping cough, and they remain a very important model of bacterial sepsis. Additionally, baboons are excellent models of human COVID associated pneumonia, and they were instrumental in the development of approved vaccines for SARS CoV-2. Over the next five years, the SPF18BRR will focus on expanding the SPF18 baboon breeding colony to meet current and future biomedical research needs. The aims of the Resource Core Component address our continued commitment to expanding the SPF18 baboon breeding colony, we will increase the genetic diversity of the SPF18 breeding colony, and we will provide SPF18 baboons, facilities, training, and expertise to the scientific community. The Applied Research Component will include projects to develop methods to train and collect data from automated cognitive testing systems in socially living baboons; we will also determine a DNA methylation clock for our baboon colony, and will perform baseline biomarker analysis for a panel of 30 biomarkers for all animals over 3 years old in our colony; and, we will perform whole genome sequencing on 9 future conventional baboon breeders from the Southwest National Primate Center’s olive baboon colony, as well as targeted genomic sequencing on other interesting animals from the SPF18BRR. The overall goals of theSPF18BRR are to provide a national research resource of virus free olive baboons; provide baboon derived biological materials; provide education and training opportunities to scientist, colony managers, and animal caregivers who want to work with baboons; and to provide investigators with facilities and expertise to conduct studies using virus free baboons.

项目摘要：整体组成部分 该应用程序是“没有特定病原体的18次狒狒研究资源”的竞争更新 （SPF18BRR）P40 OD024628。 SPF18BRR在俄克拉荷马大学的NIH支持下建立 健康科学中心（OUHSC）于2002年，并于2017年搬迁到Keeling Center。SPF18BRR 自成立以来，已经获得了连续的NIH支持。 SPF18BRR是唯一的国家研究 NIH Grandes可用的先进病毒的橄榄狒狒（Papio Anubis）的资源；壁内 联邦机构的研究计划，包括FDA，NSF和NIH；和其他生物医学赞助商 研究（私人基金会，制药公司和合同研究组织）。绝对地 SPF18BRR中的狒狒在全世界独特 通常在其他野生和俘虏的非人类私人殖民地中发现。 SPF18BRR已集成了多个 纪律进入一个计划，旨在满足利用其资源的调查人员的需求。在 拟议的支持期，SPF18BRR将继续改善其提供给用户和 将继续将有关无病毒狒狒的生物学和研究价值的新信息添加到其网站上。 狒狒仍然是基因工程猪的动物模型的重要动物模型，是 只有NHP的呼吸综合病毒和百日咳模型，它们仍然是一个非常重要的模型 细菌败血症。此外，狒狒是人类相关肺炎的极好模型，并且 他们有助于开发SARS COV-2批准的疫苗。在接下来的五年中， SPF18BRR将专注于扩大SPF18狒狒育种殖民地以满足当前和未来 生物医学研究需求。资源核心组件的目的解决了我们的续 致力于扩大SPF18狒狒繁殖菌落的承诺，我们将增加遗传多样性 SPF18繁殖殖民地，我们将为科学提供SPF18狒狒，设施，培训和专业知识 社区。应用的研究组件将包括开发培训和收集方法的项目 来自自动认知测试系统的社会生活狒狒的数据；我们还将确定DNA 我们的狒狒菌落的甲基化时钟，并将对30个面板进行基线生物标志物分析 我们殖民地中所有3岁以上动物的生物标志物；而且，我们将在 9来自西南国家灵长类中心的橄榄狒狒殖民地的未来传统狒狒育种者， 以及SPF18BRR的其他有趣动物的靶向基因组测序。总体目标 Thespf18brr的旨在提供无病毒狒狒的国家研究资源；提供 狒狒衍生的生物材料；向科学家提供教育和培训机会 想要与狒狒一起工作的经理和动物照顾者；并为调查人员提供 使用无病毒狒狒进行研究的设施和专业知识。

项目成果

Histopathology of pig kidney grafts with/without expression of the carbohydrate Neu5Gc in immunosuppressed baboons.

• DOI: 10.1111/xen.12715
• 发表时间: 2021-11
• 期刊: XENOTRANSPLANTATION
• 影响因子: 3.9
• 作者: Foote, Jeremy B.;Jagdale, Abhijit;Yamamoto, Takayuki;Hara, Hidetaka;Bikhet, Mohamed H.;Schuurman, Henk-Jan;Nguyen, Huy Q.;Ezzelarab, Mohamed;Ayares, David;Anderson, Douglas J.;Fatima, Huma;Eckhoff, Devin E.;Cooper, David K. C.;Iwase, Hayato
• 通讯作者: Iwase, Hayato

Observations on hydronephrosis after pig kidney transplantation in baboons.

• DOI: 10.1111/xen.12779
• 发表时间: 2022-11
• 期刊: XENOTRANSPLANTATION
• 影响因子: 3.9
• 作者: Foote, Jeremy B.;Bikhet, Mohamed H.;Hansen-Estruch, Christophe;Javed, Mariyam;Ayares, David;Hara, Hidetaka;Humar, Abhinav;Eckhoff, Devin E.;Cooper, David K. C.
• 通讯作者: Cooper, David K. C.

Physiological aspects of pig kidney xenotransplantation and implications for management following transplant.

• DOI: 10.1111/xen.12743
• 发表时间: 2022-05
• 期刊: XENOTRANSPLANTATION
• 影响因子: 3.9
• 作者: Hansen-Estruch, Christophe;Cooper, David K. C.;Judd, Eric
• 通讯作者: Judd, Eric

A global catalog of whole-genome diversity from 233 primate species

• DOI: 10.1126/science.abn7829
• 发表时间: 2023-06-02
• 期刊: SCIENCE
• 影响因子: 56.9
• 作者: Kuderna，Lukas F. K.;Gao，Hong;Bonet，Tomas Marques
• 通讯作者: Bonet，Tomas Marques

T and B lymphocyte dynamics after genetically-modified pig-to-baboon kidney xenotransplantation with an anti-CD40mAb-based immunosuppressive regimen.

• DOI: 10.1016/j.trim.2022.101545
• 发表时间: 2022-04
• 期刊: TRANSPLANT IMMUNOLOGY
• 影响因子: 1.5
• 作者: Jagdale, Abhijit;Huy Nguyen;Iwase, Hayato;Foote, Jeremy B.;Yamamoto, Takayuki;Javed, Mariyam;Ayares, David;Anderson, Douglas J.;Eckhoff, Devin E.;Cooper, David K. C.;Hara, Hidetaka
• 通讯作者: Hara, Hidetaka