Clinical Core

临床核心

基本信息

批准号：
10909444
负责人：
PAUL A. NEWHOUSE
金额：
$ 61.9万
依托单位：
VANDERBILT UNIVERSITY MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-08-15 至 2024-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10909444
关键词：
African American African American population Age Aging Alzheimer&apos s Disease Alzheimer&apos s disease pathology Alzheimer&apos s disease related dementia Alzheimer&apos s disease therapeutic Autopsy Biological Markers Brain Clinic Clinical Clinical Trials Cognitive Collaborations Collection Communities Complex Data Data Collection Data Set Delirium Dementia Development Disease Elderly Enrollment Fostering Future Genetic Goals Image Individual Infrastructure Injury Institution Intervention Leadership MRI Scans Magnetic Resonance Imaging Memory National Institute on Aging Participant Pathway interactions Patient Recruitments Patients Phase Prevention Procedures Protocols documentation Qualifying Recruitment Activity Registries Research Research Activity Research Institute Research Personnel Risk Sampling Site Tissues Training Training Support career clinical center cohort cooperative study data resource data sharing genomic data interest member mild cognitive impairment neuroimaging neuropathology next generation novel outreach participant retention patient engagement pharmacologic pre-clinical preservation programs recruit repository resilience telephone based

项目摘要

PROJECT SUMMARY – CLINICAL CORE The Exploratory Vanderbilt Alzheimer’s Disease Research Center (VADRC) Clinical Core will support local and national Alzheimer’s disease research activities. Under the direction of Dr. Paul Newhouse, the Clinical Core will enhance existing institutional infrastructure to engage and recruit older adults into Alzheimer’s disease and related dementia research opportunities to support creating a future P30 Outreach and Recruitment Core. Recruitment activities will build upon the existing 4000+ member Alzheimer’s Disease Research Registry and focus on recruiting memory clinic patients and community-dwelling older adults interested in biomarker-focused Alzheimer’s disease research opportunities. A strong emphasis will be placed on partnering with the Vanderbilt-Meharry Alliance for outreach and engagement in the local African American community with a focus on enhancing biomarker and autopsy participation. The Clinical Core will be responsible for establishing and annually following a “proof of concept” cohort of 150 well-characterized participants age 60 and older who are cognitively unimpaired or meet established criteria for mild cognitive impairment or Alzheimer’s disease. Leveraging well-established protocols and extensive local infrastructure, we will collect detailed clinical, cognitive, neuroimaging, genetic, and biospecimen data. These data will support our Center’s thematic emphasis on prevention targets, large-scale discovery, and pharmacological interventions that collectively emphasize non-amyloid pathways of injury commonly co-occurring with core Alzheimer’s disease pathology. The Clinical Core will engage cohort participation in antemortem brain donation assent, and a scalable autopsy protocol pipeline will be implemented to support a future P30 Neuropathology Core in collaboration with the Rush Alzheimer’s Disease Research Center. The Clinical Core will support local and national research efforts in Alzheimer’s disease by fostering collaborations and sharing data locally and nationally. Data and biospecimens will be collected in a uniform manner according to current best-practices and shared with the National Alzheimer’s Coordinating Center, the National Centralized Repository for Alzheimer’s Disease and Related Dementias, and the National Institute on Aging Genetics of Alzheimer’s Disease Storage Site. The Clinical Core will maximize local research initiatives by distributing clinical, cognitive, neuroimaging, genetic, and biospecimen data to qualified investigators and maximizing Clinical Core cohort participation in investigator initiated and multi-site studies. Finally, the Clinical Core will support training the next generation of Alzheimer’s disease clinicians and investigators by providing participants, data, biospecimens, collaboration, and leadership opportunities. Our interdisciplinary Clinical Core investigators have demonstrated expertise and a proven track record in participant recruitment and retention as well as complex protocol implementation. Thus, the Clinical Core will be a successful focal point of the VADRC in supporting both local and national Alzheimer’s disease research activities.

项目摘要 – 临床核心探索性范德比尔特阿尔茨海默病研究中心 (VADRC) 临床核心将支持当地和在临床核心 Paul Newhouse 博士的指导下开展国家阿尔茨海默病研究活动。将加强现有的机构基础设施，以吸引和招募老年人来治疗阿尔茨海默病，相关的痴呆症研究机会，以支持创建未来的 P30 外展和招聘核心。招募活动将以现有 4000 多名阿尔茨海默病研究注册中心成员为基础，专注于招募对生物标志物感兴趣的记忆诊所患者和社区老年人阿尔茨海默氏病的研究机会将重点放在与该组织的合作上。范德比尔特-梅哈里联盟致力于在当地非裔美国人社区进行外展和参与，重点关注加强生物标志物和尸检参与。临床核心将负责建立。每年都会对由 150 名 60 岁及以上的特征鲜明的参与者组成的“概念验证”队列进行跟踪研究认知能力未受损或符合轻度认知障碍或阿尔茨海默病的既定标准。利用完善的协议和广泛的当地基础设施，我们将收集详细的临床、认知、神经影像、遗传和生物样本数据将支持我们中心的主题。强调预防目标、大规模发现和药物干预，强调通常与阿尔茨海默病核心病理学同时发生的非淀粉样蛋白损伤途径。临床核心将参与死前大脑捐赠同意和可扩展的尸检将与以下组织合作实施协议管道以支持未来的 P30 神经病理学核心拉什阿尔茨海默病研究中心将支持地方和国家的研究工作。通过促进本地和全国范围内的合作和数据共享来治疗阿尔茨海默病。生物样本将根据当前最佳实践以统一方式收集并与国家阿尔茨海默病协调中心、国家阿尔茨海默病中央存储库和相关痴呆症，以及国家衰老遗传学研究所阿尔茨海默病存储站点。临床核心将通过分配临床、认知、神经影像、遗传、和生物样本数据给合格的研究人员，并最大限度地参与临床核心队列最后，临床核心将支持培训下一代。阿尔茨海默病教区居民和研究人员通过提供参与者、数据、生物样本、协作、我们的跨学科临床核心研究人员展示了专业知识和领导机会。在参与者招募和保留以及复杂协议实施方面拥有良好的记录。因此，临床核心将成为 VADRC 支持地方和国家的成功焦点阿尔茨海默病研究活动。