Clinical Core

临床核心

基本信息

批准号：
10470725
负责人：
PAUL A. NEWHOUSE
金额：
$ 105.75万
依托单位：
VANDERBILT UNIVERSITY MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-08-15 至 2024-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10470725
关键词：
African American African American population Age Aging Alzheimer&apos s Disease Alzheimer&apos s disease pathology Alzheimer&apos s disease related dementia Alzheimer&apos s disease therapeutic Autopsy Biological Markers Brain Clinic Clinical Clinical Trials Cognitive Collaborations Collection Communities Complex Data Data Collection Data Set Delirium Development Disease Elderly Enrollment Fostering Future Genetic Goals Image Individual Infrastructure Injury Intervention Leadership MRI Scans Magnetic Resonance Imaging Memory National Institute on Aging Participant Pathway interactions Patient Recruitments Patients Pharmacology Phase Prevention Procedures Protocols documentation Recruitment Activity Registries Research Research Activity Research Institute Research Personnel Risk Sampling Site Tissues Training Training Support career clinical center cohort cooperative study data resource data sharing genomic data interest member mild cognitive impairment neuroimaging neuropathology next generation novel outreach participant retention pre-clinical preservation programs ranpirnase recruit repository resilience telephone-based

项目摘要

PROJECT SUMMARY – CLINICAL CORE The Exploratory Vanderbilt Alzheimer’s Disease Research Center (VADRC) Clinical Core will support local and national Alzheimer’s disease research activities. Under the direction of Dr. Paul Newhouse, the Clinical Core will enhance existing institutional infrastructure to engage and recruit older adults into Alzheimer’s disease and related dementia research opportunities to support creating a future P30 Outreach and Recruitment Core. Recruitment activities will build upon the existing 4000+ member Alzheimer’s Disease Research Registry and focus on recruiting memory clinic patients and community-dwelling older adults interested in biomarker-focused Alzheimer’s disease research opportunities. A strong emphasis will be placed on partnering with the Vanderbilt-Meharry Alliance for outreach and engagement in the local African American community with a focus on enhancing biomarker and autopsy participation. The Clinical Core will be responsible for establishing and annually following a “proof of concept” cohort of 150 well-characterized participants age 60 and older who are cognitively unimpaired or meet established criteria for mild cognitive impairment or Alzheimer’s disease. Leveraging well-established protocols and extensive local infrastructure, we will collect detailed clinical, cognitive, neuroimaging, genetic, and biospecimen data. These data will support our Center’s thematic emphasis on prevention targets, large-scale discovery, and pharmacological interventions that collectively emphasize non-amyloid pathways of injury commonly co-occurring with core Alzheimer’s disease pathology. The Clinical Core will engage cohort participation in antemortem brain donation assent, and a scalable autopsy protocol pipeline will be implemented to support a future P30 Neuropathology Core in collaboration with the Rush Alzheimer’s Disease Research Center. The Clinical Core will support local and national research efforts in Alzheimer’s disease by fostering collaborations and sharing data locally and nationally. Data and biospecimens will be collected in a uniform manner according to current best-practices and shared with the National Alzheimer’s Coordinating Center, the National Centralized Repository for Alzheimer’s Disease and Related Dementias, and the National Institute on Aging Genetics of Alzheimer’s Disease Storage Site. The Clinical Core will maximize local research initiatives by distributing clinical, cognitive, neuroimaging, genetic, and biospecimen data to qualified investigators and maximizing Clinical Core cohort participation in investigator initiated and multi-site studies. Finally, the Clinical Core will support training the next generation of Alzheimer’s disease clinicians and investigators by providing participants, data, biospecimens, collaboration, and leadership opportunities. Our interdisciplinary Clinical Core investigators have demonstrated expertise and a proven track record in participant recruitment and retention as well as complex protocol implementation. Thus, the Clinical Core will be a successful focal point of the VADRC in supporting both local and national Alzheimer’s disease research activities.

项目摘要 - 临床核心探索性范德比尔特阿尔茨海默氏病研究中心（VADRC）临床核心将支持本地和国家阿尔茨海默氏病研究活动。在临床核心保罗·纽豪斯（Paul Newhouse）博士的指导下将加强现有的机构基础设施，以参与和招募老年人进入阿尔茨海默氏病和相关的痴呆症研究机会，以支持创建未来的P30外展和招聘核心。招聘活动将建立在现有4000多名老年痴呆症研究注册中心的基础上专注于招募记忆诊所患者和对以生物标志物为中心感兴趣的社区居住的老年人阿尔茨海默氏病研究机会。非常重视与范德比尔特·梅哈里（Vanderbilt-Meharry 专注于增强生物标志物和尸检。临床核心将负责建立并每年遵循150名年龄较高的150名及以上参与者的“概念证明”队列是认知性地或符合轻度认知障碍或阿尔茨海默氏病的既定标准。利用良好的协议和广泛的本地基础设施，我们将收集详细的临床，认知，神经影像学，遗传和生物测定数据。这些数据将支持我们中心的主题强调预防目标，大规模发现和药物干预措施强调损伤的非淀粉样途径通常与阿尔茨海默氏病病理学同时发生。临床核心将参与天表大脑捐赠和可扩展尸检的队列参与协议管道将实施，以支持未来的P30神经病理学核心拉什阿尔茨海默氏病研究中心。临床核心将支持本地和国家研究工作在阿尔茨海默氏病中，通过促进合作并在本地和全国共享数据。数据和生物测量将根据当前的最佳实践以统一的方式收集，并与国家阿尔茨海默氏症协调中心，阿尔茨海默氏病的国家集中库和相关的痴呆症和美国阿尔茨海默氏病遗传遗传学的国家遗传学研究所。这临床核心将通过分发临床，认知，神经影像，遗传，以及对合格研究者的生物循环数据，并最大化临床核心队列参与研究者启动和多站点研究。最后，临床核心将支持培训下一代阿尔茨海默氏病临床医生和调查人员通过为参与者，数据，生物测量，协作，合作，和领导机会。我们的跨学科临床核心研究人员已经证明了专业知识和参与者招聘和保留以及复杂的协议实施方面有一个可靠的记录。这是临床核心将是VADRC支持本地和国家的成功焦点阿尔茨海默氏病研究活动。