PHYSICAL ACTIVITY, TESTOSTERONE AND COGNITION IN OLDER MEN

老年男性的体力活动、睾酮和认知

• 批准号: 8166979
• 负责人: PAUL A. NEWHOUSE
• 金额: $ 1.2万
• 依托单位: UNIVERSITY OF VERMONT & ST AGRIC COLLEGE
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-03-01 至 2011-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8166979
• 关键词: Advertisements; Age; Alzheimer' s Disease; Blood; Cognition; Cognitive; Computer Retrieval of Information on Scientific Projects Database; Data; Elderly; Exercise; Fitness Centers; Funding; Grant; Health; Homes for the Aged; Impaired cognition; Institution; Learning; Literature; Measurement; Measures; Memory; Monitor; Newspapers; Outcome Study; Participant; Patient Self-Report; Performance; Physical activity; Pilot Projects; Population; Public Health; Recruitment Activity; Research; Research Personnel; Resources; Source; Testosterone; Time; United States National Institutes of Health; Visit; Wrist; aging population; diaries; interest; men; older men

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Much has been said about the benefits of exercise to health. With our aging population, we are particularly interested in studying the relationship between physical activity and cognitive abilities (e.g. learning and memory) in the elderly populations. Currently, a number of studies on this relationship can be found in the literature, with some evidence suggesting that exercise provides benefits in protecting cognitive decline in old age. However, this conclusion remains unclear as a number of studies failed to show this relationship. Other studies involving older men suggested that low testosterone level is related to cognitive decline and Alzheimer's disease. Here, we propose a study to collect data on the amount of physical activity, memory performance, and testosterone levels in 30 healthy men between the age of 65 to 85. Participants will be recruited through advertisement at fitness centers, senior homes, as well as in newspapers. We aim to recruit 15 men with high activity (men who regularly exercise at least 3 times a week) and 15 men with low activity (men who exercise less than 2 times a week). The study period for each participant will be 2 weeks. Participants will wear a small activity monitor on their wrist and keep an activity diary through 2 weeks. At the end of the 2-week period, activity data (both measured and self-reported) will be collected. In addition, they will complete two memory tasks and have a blood draw for testosterone level measurement at their last visit at the end of the 2-week study period. The data collected in this pilot study will be analyzed to see if there is a relationship between the amount of physical exercise, memory performance and testosterone level in older men. The outcome of this study will provide useful research information, at the same time carry important public health implications.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 关于运动对健康的好处已经有很多说法。随着人口老龄化，我们特别有兴趣研究老年人口中的体育活动与认知能力（例如学习和记忆）之间的关系。目前，文献中可以找到有关这种关系的许多研究，其中一些证据表明，运动为保护老年认知能力下降提供了好处。但是，由于许多研究未能表明这种关系，因此该结论尚不清楚。其他涉及老年男性的研究表明，低睾丸激素水平与认知能力下降和阿尔茨海默氏病有关。 在这里，我们提出了一项研究，以收集30名健康男性65至85岁健康男性的体育活动，记忆表现和睾丸激素水平的数据。将通过在健身中心，高级家庭以及报纸的广告中招募参与者。我们的目标是招募15名活动较高的男性（每周定期运动3次）和15名活动较低的男性（每周运动少于2次）。每个参与者的学习期为2周。参与者将在手腕上佩戴小型活动监视器，并在2周内保持活动日记。在2周结束时，将收集活动数据（测量和自我报告）。此外，他们将完成两项记忆任务，并在2周学习期结束时上次访问时进行抽血以进行睾丸激素水平的测量。 将分析此试点研究中收集的数据，以查看老年男性体育锻炼，记忆表现和睾丸激素水平之间是否存在关系。这项研究的结果将提供有用的研究信息，同时具有重要的公共卫生影响。