African American Eye Disease Study

非洲裔美国人眼病研究

基本信息

批准号：
9549238
负责人：
ROHIT VARMA
金额：
$ 91.09万
依托单位：
UNIVERSITY OF SOUTHERN CALIFORNIA
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-09-30 至 2019-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9549238
关键词：
Adult African African American Age Age related macular degeneration Aging American Area Baltimore Behavioral Biological Biology Blindness Blood Pressure Blood flow Caring Childhood Chinese American Clinical Clinical Trials Data Development Diabetes Mellitus Diabetic Retinopathy Disease Ethnic group Evaluation Exhibits Eye Eye diseases Glaucoma Glycosylated hemoglobin A Goals Habits Happiness High Prevalence Hispanics Hypertension Incidence Knowledge Latino Lens Opacities Life Los Angeles Maryland Measures Minority Not Hispanic or Latino Obesity Open-Angle Glaucoma Participant Pattern Persons Physiologic Intraocular Pressure Population Population Study Prevalence Preventive measure Protocols documentation Quality of life Recommendation Recording of previous events Reporting Retinal Risk Risk Factors Smoking Standardization Surveys Testing United States Update Visual impairment age related aged clinical practice clinical risk cohort design epidemiology study experience follow-up glycemic control health related quality of life high risk population based programs public health relevance racial and ethnic screening skills treatment program

项目摘要

DESCRIPTION (provided by applicant): African Americans (AAs) are one of the largest minority populations in the United States. In 2011, 43.2 million persons in the US (14.1%) were of African ancestry. AAs exhibit a different pattern of eye disease than other racial/ethnic groups and are largely under-represented in studies of eye disease. Specifically, AAs are believed to have higher rates of visual impairment, blindness, open angle glaucoma (OAG), diabetic retinopathy (DR) but lower rates of age-related macular degeneration (AMD) than Non-Hispanic Whites (NHW) (1-5). However, most of the data that inform our estimates of the burden of eye disease in AAs are from two population based assessments initiated and conducted 20-28 years ago in Maryland (The Baltimore Eye Survey [1985-88] and The Salisbury Eye Evaluation Project [1993-95] (1, 6)). Since the completion of these two population-based studies, results of numerous clinical trials have reported the benefits of tighter glycemic control on the development of DR, and lower intraocular pressure on the development and progression of glaucoma. Findings from these two population based studies (showing the higher risk of vision loss, OAG and DR in AAs) have been incorporated into screening programs and clinical practice. Finally, with the aging of the U.S. population, the burden of age-related eye disease is likely to increase among AAs who are disproportionately impacted by obesity and diabetes. Given the implementation of numerous screening programs on AAs, the aging of the AA population, important changes in clinical practice, and the lack of recent population-based prevalence estimates, updated estimates of the burden of eye disease in AAs are needed. Characterization of the prevalence, the biological mechanisms (i.e., the risk relationships) of these diseases, and their impact on activities of daily life needs to be completed to allow for planning of preventive measures, and targeted screening and treatment programs. Further, it is crucial to determine the underlying reasons AAs may receive less follow-up eye care. Finally, while current data exists on the incidence of eye disease in NHW and Latinos, this study creates a cohort for obtaining the first incidence data on eye disease in AAs.

描述（由申请人提供）：非裔美国人 (AA) 是美国最大的少数族裔人口之一。 2011年，美国有4320万人（14.1%）有非洲血统。与其他种族/族裔群体相比，AA 表现出不同的眼病模式并且在眼病研究中代表性不足。具体而言，与非西班牙裔白人 (NHW) 相比，AA 被认为视力障碍、失明、开角型青光眼 (OAG)、糖尿病视网膜病变 (DR) 的发生率较高，但年龄相关性黄斑变性 (AMD) 的发生率较低 (1- 5）。然而，我们对 AA 眼病负担估计的大多数数据都来自 20-28 年前在马里兰州发起和进行的两项基于人群的评估（巴尔的摩眼科调查 [1985-88] 和索尔兹伯里眼科评估项目） [1993-95] (1, 6))。自这两项基于人群的研究完成以来，大量临床试验的结果报告了更严格的血糖控制对 DR 的发展以及降低眼压对青光眼的发展和进展的益处。这两项基于人群的研究结果（显示 AA 中视力丧失、OAG 和 DR 的风险较高）已被纳入筛查计划和临床实践中。最后，随着美国人口的老龄化，AA 中与年龄相关的眼部疾病的负担可能会增加，因为他们受到肥胖和糖尿病的影响尤为严重。鉴于对 AA 进行了大量筛查计划、AA 人群的老龄化、临床实践的重大变化以及缺乏近期基于人群的患病率估计，需要对 AA 眼病负担进行更新的估计。需要完成这些疾病的患病率、生物学机制（即风险关系）及其对日常生活活动的影响的表征，以便规划预防措施以及有针对性的筛查和治疗计划。此外，确定 AA 接受较少后续眼部护理的根本原因也至关重要。最后，虽然现有关于 NHW 和拉丁裔眼病发病率的数据，但本研究创建了一个队列，以获得第一个 AA 眼病发病率数据。

项目成果

期刊论文数量（1）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

The African American Eye Disease Study: Design and Methods.

非裔美国人眼病研究：设计和方法。

DOI：
发表时间：
2018-08
期刊：
影响因子：
1.8
作者：
McKean;Fairbrother;Torres, Mina;Lastra, Carlos;Choudhury, Farzana;Jiang, Xuejuan;Burkemper, Bruce;Varma, Rohit;African American Eye Disease Study Group
通讯作者：
African American Eye Disease Study Group