Chinese American Eye Study

华裔美国人眼科研究

• 批准号: 8231449
• 负责人: ROHIT VARMA
• 金额: $ 249.03万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8231449
• 关键词: Acculturation; African American; Age; Age related macular degeneration; Aging; American; Angle-Closure Glaucoma; Anisometropia; Area; Asian Americans; Asians; Astigmatism; Biology; Biology of Aging; Biometry; Blindness; Blood Glucose; Body mass index; C-reactive protein; Caliber; California; Candidate Disease Gene; Caring; Cataract; Censuses; Characteristics; Childhood; Chinese American; Chinese People; Cornea; County; Data; Demographic Factors; Diabetic Angiopathies; Diabetic Retinopathy; Disease; Education; Epidemiologic Studies; Ethnic group; Exhibits; Exudative age-related macular degeneration; Eye; Eye diseases; Far East; Fundus; Genes; Genetic Determinism; Genotype; Glaucoma; Glycosylated hemoglobin A; Hypertension; Image; Inflammatory; Interleukin-6; Interview; Latino; Lead; Length; Lens Opacities; Life; Lipids; Los Angeles; Measurement; Measures; Methodology; Myopia; Not Hispanic or Latino; Nuclear; Open-Angle Glaucoma; Ophthalmic examination and evaluation; Optic Disk; Optic Nerve; Optical Coherence Tomography; Pattern; Persons; Phenotype; Physiologic Intraocular Pressure; Population; Prevalence; Preventive; Primary Angle Closure Glaucoma; Public Health; Race; Refractive Errors; Rehabilitation therapy; Research Design; Research Infrastructure; Retinal; Retinal Diseases; Risk; Risk Factors; Role; Sampling; Serum; Services; Smoking; Subgroup; Testing; Thick; Ultrasonics; United States; Variant; Venous; Visual Acuity; Visual Fields; Visual impairment; Vitreous Chamber; age related; aged; anterior chamber; arteriole; base; cardiovascular risk factor; cycloplegic; design; diabetic; genetic variant; improved; inflammatory marker; lens; macula; macular edema; metropolitan; middle age; non-diabetic; novel; population based; racial and ethnic; retinal nerve fiber layer; study characteristics; venule

DESCRIPTION (provided by applicant): Visual impairment and the major ocular conditions that lead to visual impairment continue to be a significant public health burden in middle-aged and older Americans. While several large, well-designed, population based ocular disease studies of US whites, blacks, and Latinos have been conducted, there is almost no information on the prevalence, risk factors, and genetic determinants in Asian Americans-one of the fastest growing racial groups in the US. There are known to be significant racial/ethnic variations in the burden of eye disease, and studies from East Asia suggest that Asians have a spectrum of eye diseases different from that of whites, African Americans, and Latinos. Because the largest Asian subgroup in the US is that of Chinese descent, in this proposed study we will determine cause-specific rates of blindness, visual impairment, and ocular disease (including cataract) in Chinese Americans aged 50 years and older. In addition, we will measure the degree to which biometric, inflammatory, and microvascular risk factors are associated with eye disease. Finally, we will examine genetic determinants of AMD and Glaucoma in this racial/ethnic group. All Chinese American residents living in the nine census tracts in Monterey Park, California, aged 50 years and older, will be invited to undergo an interview and a comprehensive eye examination, including measurement of visual acuity, visual field, intraocular pressure, hemoglobin A1c, blood glucose, and serum C-reactive protein; additional tests will include optical coherence tomography of the anterior chamber angle, ultrasonic measurement of the anterior chamber depth and lens thickness, and imaging of the fundus and optic nerve. The standardized study design and methodology will allow us to compare our data in Chinese Americans with previously obtained estimates in whites, African Americans, and Latinos. These data will improve our understanding of the biology of these age-related eye diseases. Our findings will help in planning preventive, rehabilitative, and eye care services. These findings are also likely to be of increasing public health importance, as the societal burden of age-related eye disease will likely increase with the aging of this rapidly growing segment of the US population.

描述（由申请人提供）：视力障碍和导致视力障碍的主要眼部疾病仍然是美国中老年人的重大公共卫生负担。虽然已经对美国白人、黑人和拉丁裔进行了几项大型、精心设计、基于人群的眼病研究，但几乎没有关于亚裔美国人（增长最快的种族之一）的患病率、危险因素和遗传决定因素的信息。美国的团体。众所周知，眼病负担存在显着的种族/民族差异，东亚的研究表明，亚洲人患有一系列与白人、非裔美国人和拉丁裔不同的眼病。由于美国最大的亚裔群体是华裔群体，因此在这项拟议研究中，我们将确定 50 岁及以上华裔美国人失明、视力障碍和眼部疾病（包括白内障）的特定原因发生率。此外，我们还将测量生物特征、炎症和微血管危险因素与眼部疾病的相关程度。最后，我们将研究该种族/族裔群体中 AMD 和青光眼的遗传决定因素。所有居住在加州蒙特利公园市九个人口普查区的50岁及以上的华裔居民将被邀请接受面谈和全面的眼科检查，包括测量视力、视野、眼压、血红蛋白A1c、血糖和血清C反应蛋白；其他测试将包括前房角的光学相干断层扫描、前房深度和晶状体厚度的超声波测量以及眼底和视神经的成像。标准化的研究设计和方法将使我们能够将华裔美国人的数据与之前获得的白人、非裔美国人和拉丁裔美国人的估计数据进行比较。这些数据将增进我们对这些与年龄相关的眼部疾病的生物学的理解。我们的研究结果将有助于规划预防、康复和眼保健服务。这些发现也可能对公共卫生具有越来越重要的意义，因为随着美国人口迅速增长的这一群体的老龄化，与年龄相关的眼病的社会负担可能会增加。