Frontiers: University of Kansas Clinical and Translational Science Institute

前沿：堪萨斯大学临床与转化科学研究所

基本信息

批准号：
9560956
负责人：
Richard J. Barohn
金额：
$ 402.38万
依托单位：
UNIVERSITY OF KANSAS MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-09-07 至 2022-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9560956
关键词：
Academia Address Advocacy Advocate African American American Indians Automobile Driving Award Birth Childhood Cities Clinic Clinical Clinical Research Clinical Sciences Collaborations Communities Competence Complex Data Data Analyses Decision Making Development Discipline Disease Elderly Electronic Health Record Ensure Entrepreneurship Ethics Funding Generations Goals Good Clinical Practice Government Health Health Sciences Healthcare Individual Industry Informatics Information Dissemination Institutes Institution Institutional Review Boards Interdisciplinary Study Kansas Knowledge Latino Lead Leadership Link Longevity Medical Medical Device Medical Informatics Medical center Methods Midwestern United States Participant Patients Pharmaceutical Preparations Pilot Projects Population Heterogeneity Positioning Attribute Prisons Process Rare Diseases Registries Research Research Design Research Infrastructure Research Personnel Research Support Research Training Resource Informatics Resources Rural Population Science Scientific Advances and Accomplishments Texas Training Training Programs Translating Translational Research Universities Vision Workforce Development base catalyst clinical care community partnership drug discovery end of life frontier implementation research improved industry partner innovation multi-site trial multidisciplinary next generation novel novel strategies patient engagement patient oriented point of care population health precision medicine product development programs recruit service organization support tools tool

项目摘要

Contact PD/PI: Barohn, Richard Joel OVERALL: ABSTRACT Frontiers: The Heartland Institute for Clinical and Translational Research has been a catalyst for bringing together translational science investigators and stakeholders across the KC region, and beyond. Located at the University of Kansas Medical Center (KUMC) under the leadership of Dr. Barohn, our commitment to team science and multidisciplinary collaboration reaches beyond the walls of our academic health science center and promotes collaboration among investigators from diverse disciplines across local partner academic institutions and affiliated health care institutions. The vision of Frontiers is to contribute to and lead national efforts to transform the way we do clinical and translational research (CTR), and to ensure research is more rapidly and more efficiently translated to the point of care so that it may contribute to improved health. Specifically, Frontiers aims to: 1) Engage in bi-directional collaboration with all stakeholders to develop, demonstrate, and disseminate advances across the translational science spectrum that insures inclusion and integration of complex and diverse populations and individuals across the lifespan from birth to end of life; 2) Create a sustainable translational workforce of multi-disciplinary investigators, research personnel, and community and patient stakeholders in the use of translational science tools through innovative and creative programs; and 3) Strengthen institutional and regional infrastructure to accelerate translational research. We will accomplish these aims by drawing on our considerable strengths: a) developing informatics tools for making EHR data `research ready' and implementing clinic- and community-based registries for study recruitment and other translational research applications; b) nurturing and sustaining strong patient and community engagement relationships that will support research with African American, Latino, American Indian, LGBTQ, pediatric, geriatric, rare disease, prison, and rural populations; c) offering innovative training programs for the entire CTR workforce (not just investigators), including plans for comprehensive entrepreneurship and implementation research training and creating new team science brainstorming mechanisms that will lead to multidisciplinary discovery projects and d) advancing medical devices and re-purposed drugs to patients through novel strategies developed by Frontiers' Institute for Advancing Medical Innovations (IAMI)that is nationally known for its product development translational research and high impact collaborations with industry, academia, government, and disease philanthropy partners. All Frontiers units are linked by a group of Navigators that can be accessed by Frontiers investigative teams and community partners. These plans position Frontiers to contribute to goals, and lead initiatives of the CTSA network by building on technological, computational, and health/disease knowledge to advance translational research. Project Summary/Abstract Page 274 Contact PD/PI: Barohn, Richard Joel OVERALL NARRATIVE Frontiers: The Heartland Institute for Clinical and Translational Research provides infrastructure and educational programs to develop the next generation of CTR investigative teams. As a regional organization involving two states and three universities, Frontiers is able to blend the best resources available to advance team, community and clinical translational science. This results in accelerating discoveries and research findings that may be more rapidly brought to the point of care and contribute to population health.

联系人 PD/PI：Barohn、Richard Joel 总体：摘要前沿：Heartland 临床和转化研究所一直是推动堪萨斯城地区及其他地区的转化科学研究者和利益相关者共同努力。位于在 Barohn 博士的领导下的堪萨斯大学医学中心 (KUMC)，我们的承诺团队科学和多学科合作超越了我们学术健康的范围科学中心，并促进当地不同学科的研究人员之间的合作合作学术机构和附属医疗保健机构。 Frontiers 的愿景是贡献领导国家努力改变我们进行临床和转化研究（CTR）的方式，并确保研究更快速、更有效地转化为护理点，以便它可以做出贡献改善健康状况。具体来说，Frontiers 的目标是： 1) 与所有各方进行双向合作利益相关者开发、展示和传播转化科学的进步确保包容和融合复杂多样的人口和个人的频谱从出生到生命终结的寿命； 2) 创建一支可持续的多学科翻译队伍研究者、研究人员以及社区和患者利益相关者在使用转化技术时通过创新和创意项目的科学工具； 3) 加强机构和区域加速转化研究的基础设施。我们将通过利用我们的资源来实现这些目标相当大的优势：a) 开发信息学工具，使 EHR 数据“为研究做好准备” 实施基于临床和社区的研究招募和其他转化研究登记应用程序； b) 培育和维持牢固的患者和社区参与关系，这将支持非裔美国人、拉丁裔、美洲印第安人、LGBTQ、儿科、老年、罕见的研究疾病、监狱和农村人口； c) 为整个 CTR 提供创新的培训计划劳动力（不仅仅是调查人员），包括全面创业和实施的计划研究培训和创建新的团队科学集思广益机制，这将导致多学科发现项目和 d) 向患者推进医疗设备和重新利用药物通过前沿医学创新促进研究所 (IAMI) 制定的新颖策略，以其产品开发转化研究和与以下机构的高影响力合作而闻名全国工业界、学术界、政府和疾病慈善事业合作伙伴。所有 Frontiers 单位都通过一个 Frontiers 调查团队和社区合作伙伴可以访问的导航器组。这些计划使 Frontiers 能够为目标做出贡献，并通过构建 CTSA 网络来领导 CTSA 网络的举措技术、计算和健康/疾病知识，以推进转化研究。项目摘要/摘要第 274 页联系人 PD/PI：Barohn、Richard Joel 整体叙述前沿：Heartland 临床和转化研究所提供基础设施和培养下一代 CTR 调查团队的教育计划。作为一个区域组织 Frontiers 涉及两个州和三所大学，能够整合可用的最佳资源来推进团队、社区和临床转化科学。这会加速发现和研究这些发现可能会更快地送到护理点并有助于人口健康。