Long Lasting Organic Semiochemical Formulation to Effectively Manage Blood Sucking Diptera.

持久的有机化学制剂可有效控制吸血双翅目。

• 批准号: 10565865
• 负责人: Agenor Mafra-Neto
• 金额: $ 100万
• 依托单位: ISCA TECHNOLOGIES, INC.
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-07-12 至 2025-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10565865
• 关键词: Adoption; Adult; Aedes; Air; Anopheles Genus; Area; Bacillus thuringiensis; Bacteria; Bacterial Artificial Chromosomes; Beds; Behavior; Biological; Blood; Blood-Borne Pathogens; Brazil; Breeding; Chemicals; Collection; Consumption; Control Groups; Culex (Genus); Culicidae; Data; Dengue; Diptera; Dryness; Ensure; Environment; Exposure to; Female; Floods; Food; Formulation; Fostering; Friends; Grant; Habitats; Home; Human Bites; Infection; Ingestion; Insecticides; International; Intervention; Invaded; Juvenile Hormones; Larva; Left; Life; Malaria; Marketing; Measures; Methoprene; Mosquito Control; Mosquito-borne infectious disease; Names; Nature; Organophosphates; Oviposition; Partner in relationship; Penetration; Persons; Pest Control; Phase; Pilot Projects; Population; Predisposition; Process; Rain; Readiness; Regulation; Research; Residual state; Resistance; Resistance development; Risk; Risk Reduction; Running; Safety; Sales; Sedimentation process; Semiochemicals; Site; Source; Stimulant; Surface; Tanzania; Technology; Temephos; Toxin; United States National Institutes of Health; Variant; Vectorial capacity; Water; West Nile virus; ZIKA; commercialization; controlled release; design; disease transmission; efficacy trial; egg; feeding; larval control; malaria mosquito; malaria transmission; mortality; novel; outbreak control; preference; prevent; programs; pyrethroid; research and development; success; sucking; transmission process; vector; vector management strategies; vector mosquito

Project Summary: SPLAT BAC Plus is a unique controlled-release larvicide designed to suppress populations of multiple species of mosquitoes, such as those that transmit malaria, dengue, and West Nile virus (WNV). This CRP proposal seeks to establish SPLAT BAC Plus as an effective, economically viable control strategy for use in integrated vector management (IVM) programs and for control of nuisance mosquitoes around the globe. SPLAT BAC Plus has several advantages over previous larvicides: 1) It contains a combination of larvicidal agents with different modes of action: Bacillus thuringiensis israelensis (Bti), B. sphaericus (Bsp) [recently renamed Lysinibacillus sphaericus]—two bacteria that destroy the gut of mosquitoes that ingest them—and an insect growth regulator (IGR), such as methoprene or pyriproxyfen, that prevents larvae from developing into adults. This combination drastically reduces the risk of resistance compared to single-action larvicides. While there are products on the market combining Bti and Bsp, the inclusion of an IGR in SPLAT BAC Plus will further inhibit the development of resistance and greatly extend the field life of the larvicide. 2) SPLAT BAC Plus includes components that promote larval attraction and feeding on the formulation—intensifying their exposure to the Bti, Bsp, and IGR contained within it—and oviposition attractants (attractants for egg-laying females). As point sources of SPLAT BAC Plus float at the surface of treated water, these attractants are released into the air, enticing female mosquitoes to lay their eggs preferentially at that site. 3) SPLAT BAC Plus can be applied to potential larval habitats under dry conditions ahead of rainfall, a major advantage over most larvicides, which must be applied shortly after these sites fill with water to catch mosquito larvae at a susceptible stage. 4) Following application, SPLAT BAC Plus cures and becomes rainfast, becoming activated when the surfaces are submerged for a few days, detaching and floating to the water's surface and releasing its attractants. After this point, SPLAT BAC Plus remains buoyant and effective for up to 5 months, considerably longer than the 1–2 week-field life associated with older Bti/Bsp larvicides. 5) SPLAT BAC Plus contains environmentally safe larvicides and semiochemical attractants incorporated in an inert matrix composed of food-safe ingredients. To achieve global commercialization of SPLAT BAC Plus, ISCA Technologies intends to pursue the following Specific Aims: 1) Obtain the required regulatory approvals to begin sales of SPLAT BAC Plus in the US and begin penetration of target international markets (e.g., Brazil, Tanzania); 2) Foster consumer support and buy-in via demonstration trials of SPLAT BAC Plus with targeted distributors of mosquito control products, pest control operators (PCOs), and mosquito control districts; and 3) Utilize SPLAT BAC Plus to launch a more diversified product line of mosquito control technologies, designed to conform to the different needs of various mosquito control groups and consumers, such as varying target species, environmental and safety concerns, and difficulties with resistance to different control agents.

项目摘要： Splat Bac Plus是一种独特的控制释放幼虫，旨在抑制多种种群的种群 蚊子，例如传播疟疾，登革热和西尼罗河病毒（WNV）的蚊子。这个CRP提案寻求 建立SPLAT BAC加作为一种有效的，经济上可行的控制策略，用于综合向量 管理（IVM）计划，以控制全球的滋扰蚊子。 Splat Bac Plus具有 比以前的幼虫的几个优点：1）它包含具有不同模式的幼虫剂的组合 作用：苏云金芽孢杆菌以色列人（BTI），B。sphaericus（BSP）[最近更名为Lysinibacillus Sphaericus] - 两种细菌破坏了摄取它们的蚊子的肠道 - 和一个绝缘生长调节剂 （IGR），例如Methodprene或pyryfen，可防止幼虫发展成为成年人。这种组合 与单一作用幼虫相比，大幅度降低了耐药性的风险。虽然有产品 将BTI和BSP结合在一起的市场，将IGR纳入Splat Bac Plus将进一步抑制开发 抗性和巨大的延长了幼虫的野生寿命。 2）Splat Bac Plus包括 促进幼虫吸引力并以公式为食 - 强调其暴露于BTI，BSP和IGR 其中包含在其中 - 产卵吸引剂（卵子雌性的吸引剂）。作为Splat的点源 Bac Plus在处理水面的表面上漂浮，这些景点被释放到空中，诱使女性 蚊子优先在该地点产卵。 3）Splat Bac Plus可以应用于潜在的幼虫 在降雨前的干燥条件下的栖息地，这是大多数幼虫的主要优势，必须应用于 这些地点充满水以在易感阶段捕获蚊子幼虫。 4）申请后， Splat Bac Plus治疗疗法并变成雨水，当表面被浸入少量时会激活 天，脱落并漂浮到水面并释放其景点。此后，Splat Bac Plus 保持浮力且有效长达5个月，考虑比与1-2个周场相关的生活更长 较旧的BTI/BSP幼虫。 5）Splat Bac Plus包含环境安全的幼虫和半化学 吸引剂掺入由食品安全成分组成的惰性基质中。实现全球 Splat BAC Plus的商业化，ISCA技术打算追求以下特定目的：1） 获得所需的监管部门批准，以开始在美国开始销售Splat Bac Plus并开始渗透 目标国际市场（例如，巴西，坦桑尼亚）； 2）培养消费者的支持和通过演示来买入 Splat BAC Plus的试验与蚊子控制产品的有针对性分销商，害虫控制操作员（PCOS）， 和蚊子控制区； 3）利用Splat Bac Plus推出更多元化的产品线 蚊子控制技术，旨在符合各种蚊子对照组的不同需求 和消费者，例如不同的目标物种，环境和安全问题以及困难 对不同控制剂的抗性。